Figure 1
From: Phosphoinositide 3-kinase: a critical signalling event in pulmonary cells
The PI-3K signalling network. Binding of ligand to receptors linked to G protein or tyrosine kinase activates PI-3K-γ and PI-3K-α, PI-3K-β or PI-3K-δ respectively. The resultant accumulation of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5) P 3] activates downstream signalling cascades leading to adhesion, proliferation, survival and activation responses. Putative pathways or those demonstrated in only a limited number of cell types are depicted by broken arrows.