Table 1 Human acidic cathepsins
From: Importance of lysosomal cysteine proteases in lung disease
Cathepsin | Tissue expression | Chromosome | Human disease*/mouse phenotype†|
|---|---|---|---|
B | Widespread | 8 | †Reduced apoptosis |
L | Widespread | 9 | †Defective CD4 selection, hair loss |
V | Thymic epithelium | 9 | - |
K | Osteoclasts, bronchial epithelium | 1q21 | *Pycnodysostosis |
S | Antigen-presenting cells | 1q21 | †Defective antigen presentation |
H | Widespread | 15 | - |
W | CD8+ T cells | 11q13 | - |
F | Macrophages, ?widespread | 11q13 | - |
C | Myeloid cells, ?others | 11q14 | *Hyperkeratosis, periodontitis |
O | Widespread | 4q31-32 | - |
Z | Widespread | 20q13 | - |