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Table 2 The effects of dexamethasone and GW5074 on inflammatory lesions of the trachea segments isolated from the sidestream smoke-exposed mice

From: The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice

Group

dose (mg/kg)

n

inflammatory cells infiltration scores

tracheal mucous gland hypertrophy scores

Total scores

Fresh air

-

7

0.00 ± 0.00†

0.00 ± 0.00†

0.00 ± 0.00†

Smoke

-

7

3.00 ± 0.31

3.14 ± 0.26

6.14 ± 0.40

Dex

0.3

7

1.57 ± 0.20†

1.71 ± 0.29†

3.29 ± 0.29†

Dex

1.0

7

1.14 ± 0.14†

1.29 ± 0.18†

2.43 ± 0.20†#

GW5074

0.5

7

2.00 ± 0.22*

2.14 ± 0.34*

4.14 ± 0.40†

GW5074

2

7

1.43 ± 0.20†

1.57 ± 0.30†

3.00 ± 0.31†#

  1. Data are expressed as the means (SEM). Dex, dexamethasone * p < 0.05, † p < 0.01, compared with the sidestream smoke-exposed group, # p < 0. 05, compared with the low dosage group.