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Table 3 Weighted GSMA for bronchial hyper-responsiveness (989 pedigrees, n = 4,294)

From: Meta-analysis of genome-wide linkage studies of asthma and related traits

     

PROBABILITY

BIN (a)

GENETIC LOCUS (b)

DISTANCE (cM) (c)

PHYSICAL POSITION (KB) (d)

SUMMED RANK (SR)

p(SR)

p(OR)

14

2p16.2-p12

76.34–101.56

54063–79617

532.855

0.02751

0.22094

15

2p12-q22.1

101.56–128.41

79617–119705

576.585

0.00574*

0.14743

16

2q22.1-q23.3

128.41–154.48

119705–151529

518.593

0.04085

0.08859

41

5q23.2-q34

131.48–164.19

123774–162087

551.701

0.01511

0.09586

44

6p22.3-p21.1

32.62–65.14

16854–43207

571.381

0.00716*

0.04861

50

7p21.1-p14.1

29.28–59.93

19430–40230

523.367

0.03597

0.24658

51

7p14.1-q21.11

59.93–91.67

40230–81002

518.746

0.04070

0.19114

52

7q21.11-q31.1

91.67–122.48

81002–109766

461.380

0.13926

0.02065

58

8q13.1-q22

82.84–110.20

67744–99237

468.188

0.12312

0.04443

76

11q13.3-q22.3

72.82–98.98

70185–103732

465.589

0.12913

0.01652

78

11q24.1-qter

123.00–147.77

122977-qter

579.520

0.00505*

0.46485

86

13q13.2-q22.2

26.87–58.54

33636–74875

472.999

0.11255

0.03312

111

19q12-q13.33

52.59–75.41

35843–54589

460.759

0.14078

0.01070

115

20p11-q13.13

47.52–72.27

21259–46747

476.308

0.10563

0.03503

116

20q13.13-qter

72.27–101.22

46747-qter

467.593

0.12448

0.02343

  1. Chromosomal regions with a p(SR) or p(OR) < 0.05 are shown. aBin number from GSMA (1–120 inclusive). bCytogenetic band (Taken from April 2002 Genome Browser, UCSC). cGenetic distance in Marshfield cM (not cumulative). dPhysical position in kilobase pairs (Taken from December 2006 UniSTS, NCBI/Genome Browser, UCSC). *p < 0.000417 = Genome wide significance for linkage, p < 0.0083 = Suggestive for linkage [5].
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Respiratory Research

ISSN: 1465-993X

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