Figure 1
Course of HMPV and RSV infection in the BALB/c mice. (A) Kinetics of HMPV replication in the respiratory tract. Animals were infected i.n. with 2 × 105 PFU of HMPV and viral titers were determined in nasal turbinates and lungs at the indicated time points. (B) Comparison of HMPV and RSV titers measured on day 4 and 7 p.i. in nasal turbinates and lungs of mice infected with equivalent doses (2 × 105 PFU) of either virus preparation. * P < 0.05, ** P < 0.01, (n = 5–7). (C) Weight curves of HMPV- or RSV-infected BALB/c mice. Four animals per group were infected i.n. with 2 × 105 PFU of either HMPV (—) or RSV (----) and weight was recorded daily. The experiment was repeated three times with similar results. (D) Airway obstruction following HMPV, RSV or mock infection of BALB/c mice. Airway function was determined by measuring enhanced pause (Penh) via whole-body plethysmography on day 7 p.i.. *** P < 0.001, (n = 4).