Figure 7
From: Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs
Prostacyclin receptor (IP) desensitization in rabbit pulmonary smooth muscle cells. Cells were continuously stimulated with 100 nM iloprost for the indicated preincubation times. cAMP response to iloprost (100 nM) or forskolin (10 μM) was assayed in these cells and is given as a percent of the non-desensitized control. Values are expressed as mean ± SEM of three independent experiments performed in triplicate. *: p < 0.05; ***: p < 0.001 as compared to non-desensitized control.