SNP |  | N1) | MEF25 (%) Mean ± SD | MEF50 (%) Mean ± SD | MEF75 (%) Mean ± SD | FEV1 (%) Mean ± SD | FVC (%) Mean ± SD |
---|---|---|---|---|---|---|---|
F+1 | wild type | 165 | 89.82 ± 29.66 | 89.47 ± 22.54 | 91.90 ± 16.28 | 97.65 ± 11.44 | 97.64 ± 11.03 |
 | heterozygous | 232 | 91.86 ± 32.06 | 91.22 ± 22.23 | 94.48 ± 18.53 | 99.32 ± 10.57 | 99.80 ± 10.02 |
 | homozygous | 64 | 92.61 ± 23.45 | 90.28 ± 17.19 | 97.32 ± 18.00 | 98.56 ± 10.75 | 98.16 ± 10.75 |
M+1 | wild type | 317 | 90.75 ± 30.97 | 89.70 ± 22.29 | 93.19 ± 17.82 | 98.17 ± 11.43*r | 98.12 ± 11.05 |
 | heterozygous | 128 | 91.28 ± 28.43 | 91.51 ± 22.15 | 95.56 ± 17.50 | 99.01 ± 9.86 | 99.86 ± 9.83 |
 | homozygous | 4 | 109.34 ± 23.03 | 98.95 ± 12.38 | 95.75 ± 23.07 | 109.31 ± 9.13 | 105.89 ± 9.71 |
S1 | wild type | 359 | 90.57 ± 30.08 | 90.00 ± 21.74 | 93.23 ± 17.00*v | 98.29 ± 10.86 | 98.46 ± 10.72 |
 | heterozygous | 86 | 94.29 ± 31.08 | 92.01 ± 24.43 | 97.23 ± 21.03 | 99.63 ± 11.23 | 99.58 ± 10.02 |
 | homozygous | 4 | 73.47 ± 16.07 | 76.17 ± 10.97 | 78.46 ± 11.72 | 90.84 ± 5.11 | 96.06 ± 1.40 |
S2 | wild type | 215 | 91.22 ± 31.50 | 89.69 ± 22.15 | 92.14 ± 17.03*d | 97.50 ± 11.49*d | 96.97 ± 11.32*v*d |
 | heterozygous | 202 | 91.30 ± 29.78 | 91.43 ± 22.16 | 96.12 ± 18.27 | 99.76 ± 10.73 | 100.55 ± 9.99 |
 | homozygous | 31 | 95.31 ± 21.52 | 90.93 ± 22.04 | 94.54 ± 20.57 | 99.55 ± 9.27 | 98.70 ± 9.25 |
ST+4 | wild type | 158 | 90.05 ± 29.28 | 89.70 ± 22.41 | 93.18 ± 18.52 | 98.08 ± 10.38 | 99.09 ± 10.01 |
 | heterozygous | 223 | 92.00 ± 29.50 | 91.32 ± 22.23 | 94.83 ± 18.14 | 99.06 ± 11.75 | 98.61 ± 11.11 |
 | homozygous | 65 | 92.97 ± 34.91 | 90.22 ± 22.04 | 93.93 ± 14.12 | 98.68 ± 10.03 | 98.59 ± 11.39 |
ST+5 | wild type | 136 | 92.47 ± 31.51 | 91.10 ± 20.52 | 94.37 ± 15.25 | 99.26 ± 10.00 | 99.38 ± 10.88 |
 | heterozygous | 236 | 91.87 ± 29.26 | 91.02 ± 23.37 | 94.65 ± 19.04 | 98.79 ± 11.61 | 98.62 ± 10.58 |
 | homozygous | 88 | 87.50 ± 29.64 | 87.41 ± 20.55 | 91.39 ± 17.77 | 97.13 ± 10.41 | 98.48 ± 10.15 |
ST+7 | wild type | 285 | 90.28 ± 29.48 | 90.36 ± 21.92 | 93.30 ± 16.83 | 98.67 ± 10.93 | 99.10 ± 10.49 |
 | heterozygous | 158 | 94.26 ± 31.56 | 91.07 ± 22.55 | 94.99 ± 19.60 | 98.98 ± 11.11 | 98.63 ± 10.92 |
 | homozygous | 16 | 82.30 ± 24.76 | 82.94 ± 17.26 | 95.38 ± 16.31 | 93.87 ± 9.08 | 95.04 ± 7.62 |
T1 | wild type | 315 | 90.42 ± 31.04 | 89.55 ± 22.40 | 93.32 ± 17.78 | 98.07 ± 11.38 | 98.12 ± 10.83*d |
 | heterozygous | 135 | 92.59 ± 28.08 | 92.22 ± 21.39 | 95.50 ± 17.87 | 99.42 ± 9.78 | 100.10 ± 9.98 |
 | homozygous | 8 | 98.09 ± 27.48 | 90.95 ± 23.47 | 91.61 ± 19.64 | 103.91 ± 11.37 | 103.30 ± 8.53 |
T2 | wild type | 317 | 90.60 ± 31.04 | 89.61 ± 22.34 | 93.37 ± 17.71 | 98.13 ± 11.36 | 98.14 ± 10.80*d |
 | heterozygous | 135 | 92.59 ± 28.08 | 92.22 ± 21.39 | 95.50 ± 17.87 | 99.42 ± 9.78 | 100.10 ± 9.98 |
 | homozygous | 8 | 98.09 ± 27.48 | 90.95 ± 23.47 | 91.61 ± 19.64 | 103.91 ± 11.37 | 103.30 ± 8.53 |
V4 | wild type | 267 | 91.58 ± 30.15 | 89.98 ± 21.82 | 93.12 ± 17.14 | 98.24 ± 11.04 | 98.22 ± 10.82 |
 | heterozygous | 163 | 89.70 ± 30.05 | 89.71 ± 22.19 | 94.63 ± 18.60 | 98.57 ± 10.65 | 99.20 ± 10.23 |
 | homozygous | 26 | 95.52 ± 30.38 | 97.28 ± 24.60 | 96.90 ± 19.51 | 101.03 ± 11.93 | 99.82 ± 10.29 |