Table 1 Cytokine directed therapies for asthma
Treatment | Effects | Ref. | ||
|---|---|---|---|---|
Suppress AHR | Reduce eosinophilia | Other effects | ||
IFN-γ | Yes | Yes | a. IFN-γ producing T cells increased; b. Reduced IL-4 & IL-5 secretion | 60 |
IL-10 | Yes | Yes | a. Down-regulating synthesis of both Th1- & Th2- cytokines b. Reduced both eosinophilia & neutrophilia | 59 |
IL-12 | Yes | Yes | a. Th1 skewed response; b. specific IgE/IgG reduced; | 5, 9, 11 |
IL-18 | Yes | Yes | Combined IL-12 and IL-18 induce IFN-γ release | 6 |
TGF-β | Yes | Yes | Immuno- regulation, wound healing, and to shorten the inflammatory response | 13, 21 |