Table 2 Identification of risk factors for LTBI among HIV positive
From: Latent Tuberculosis in HIV positive, diagnosed by the M. Tuberculosis Specific Interferon-γ test
QTF negative (n = 543) | QTF positive (n = 27) | OR, (95% CI) | P values | |
|---|---|---|---|---|
Age, median years (25th–75th quartile) | 43 (38–50) | 42 (36–49) | P = 0.05 | |
Male sex, no (%) | 405 (75) | 17 (63) | ||
Tuberculosis | ||||
Previous TB diagnosis no. (%) | 22 (4) | 5 (19) | 4.9 (1.7–14.1) | p= 0.0063 |
Tuberculosis risk factors, no. (%) | ||||
History of exposure | 43 (8) | 8 (30) | 4.9 (2.0–11.8) | p= 0.001154 |
Long term residence in a TB endemic country a | 98 (17) | 15 (56) | 5.7 (2.6–12.5) | p= 0.000021 |
IVDU b | 59 (11) | 5 (19) | P= 0.110 | |
≥1 risk factor | 184 (34) | 21 (78) | 7.2 (2.9–18.2) | p= 0.000003 |
HIV status | ||||
Age at HIV diagnosis, median years (25th–75th quartile) | 34 (28–41) | 34 (29–40) | P = 0.11 | |
Years with HIV diagnosis, median years (25th–75th quartile) | 8.5 (4–14) | 7 (4–11.0) | P = 0.10 | |
AIDS diagnosed, no (%) | 107 (20) | 6 (22) | P = 0.18 | |
HAART treatment, no (%) | 416 (77) | 19 (70) | P = 0.13 | |
CD4 cell count, mean (± s.d.) | 523 (± 273) | 600 (± 274) | P = 0.17 | |
0–99 CD4 cells/μL, (%) | 13 (2) | 0 (0) | ||
100–199 CD4 cells/μL, (%) | 35 (6) | 1 (4) | ||
200–300 CD4 cells/μL, (%) | 55 (10) | 2 (7) | ||
>300 CD4 cells/μL,l | 440 (81) | 24 (89) | ||
HIV RNA, no (%) | ||||
<500 copies per ml | 412 (76) | 18 (67) | 0.10 | |
500 – 50,000 copies per ml | 79 (15) | 8 (30) | ||
>50,000 copies per ml | 52 (10) | 1 (4) | ||
Factors presumed to influence immune status | ||||
Diabetes, no. (%) | 18 (3) | 2 (7) | 0.18 | |
Alc. Abuse, no (%) | 59 (11) | 3 (11) | 0.24 |