Skip to main content

Table 3 β2-agonist or placebo regular inhalation and bronchoscopy protocol. Samples (lavage and brush biopsies) from five bronchoscopic procedures were obtained from the unchallenged and Ag challenged lung segments according to the procedure day indicated. Seven asthmatics enrolled in the drug arm, and 4 of these same subjects re-enrolled in the placebo arm. A baseline sample and a 24 hr post Ag challenge sample were obtained before (days 1 and 2) and after (days 18 and 19) a two week period of regular albuterol or placebo use. The initial baseline unchallenged and challenged lung segments were resampled following one additional week of regular albuterol or placebo use which were discontinued 12 hr before the final bronchoscopic procedure on day 25.

From: Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β2-agonist use

Procedure Day:

 

1

2

3–17

18

19

20–24

25

Lung Segment:

        

Lingula

(Unchallenged)

Sample

     

Sample

RML

(Challenged)

Challenge

Sample

    

Sample

    

Albuterol 2 puffs, qid

    

RLL

(Unchallenged)

   

Sample

   

LLL

(Challenged)

   

Challenge

Sample

  
       

Albuterol 2 puffs, qid