Determinants of mortality for adults with cystic fibrosis admitted in Intensive Care Unit: a multicenter study

Respiratory Research

Table 4 Univariate analysis of factors associated with mortality

	Hazard Ratio	[95% CI]	p value
Factors related to severity of CF disease in stable state
Age	1.02	[0.91–1.14]	0.701
Sex	1.39	[0.69–2.77]	0.347
BMI	0.95	[0.80–1.13]	0.614
Diabetes	0.79	[0.34–1.85]	0.595
Severity of CFTR genotype	0.84	[0.29–2.42]	0.750
P. aeruginosa colonization	1.49	[0.40–5.55]	0.544
B. cepacia complex colonization	1.95	[0.77–4.89]	0.153
FEV₁, % predicted	0.97	[0.93–1.02]	0.289
Room air PaO₂	0.96	[0.93–0.99]	0.041
Room air PaCO₂	1.01	[0.95–1.07]	0.646
Annual FEV₁ loss, % predicted/yr	1.25	[1.04–1.52]	0.019
Long-term oxygenotherapy	1.66	[0.53–5.17]	0.375
Home NIV	1.19	[0.30–4.64]	0.794
Factors related to ICU hospitalization
SAPSII	1.05	[1.02–1.08]	0.001
PaO₂ at entry	1.004	[0.999–1.009]	0.065
PaCO₂ at entry	1.01	[1.01–1.02]	0.001
Initial noninvasive ventilation	12.78	[1.63–100.25]	0.015
Initial intubation	14.57	[1.42–149.22]	0.024
Intubation during stay	16.82	[4.93–57.38]	0.001

Values are expressed as hazard ratios and 95% confidence intervals (CI) for the hazard ratios. When a patient was admitted several times, episodes were analyzed as new and independent events.
Abbreviations: CF: cystic fibrosis; ICU: intensive care unit; BMI: body mass index; CFTR: cystic fibrosis transmembrane conductance regulator; FEV₁: forced expiratory volume in one second; PaO₂: arterial oxygen tension; PaCO₂: arterial carbon dioxide tension; NIV: noninvasive ventilation; SAPSII: simplified acute physiology score II.

ISSN: 1465-993X