From: Clinical implications for Vascular Endothelial Growth Factor in the lung: friend or foe?
Disease | Associations of VEGF levels with clinical manifestations | Reference |
---|---|---|
ALI/ARDS | Association of the time-course of plasma VEGF levels with patients' outcome; higher VEGF plasma levels were found in non-survivors. Association of increased epithelial lining fluid VEGF levels with recovery. | [27] [28] |
Asthma | Negative correlation of increased VEGF levels in asthmatic patients with the degree of airway obstruction. | [4, 36] |
COPD | Negative correlation between VEGF concentrations in sputum samples with airflow limitation (as expressed by FEV1) in patients with chronic bronchitis. Positive correlation of sputum VEGF levels with FEV1 and gas exchange (as measured by the DLCO) in patients with emphysema. | [45] |
Obstructive sleep apnea | Correlation of circulating VEGF levels with the severity of OSA (as expressed by the apnea-hypopnea index) and with the degree of nocturnal desaturations. | [25, 53] [55] |
Idiopathic Pulmonary Fibrosis | Correlation of plasma VEGF levels of with the extent of parenchymal involvement in HRCT. Correlation of VEGF concentrations in BAL fluid with DLCO. | [59] [60-62] |
Tuberculosis | Higher serum VEGF levels in TB patients without cavitary lesions compared to those with typical chest cavities. | [70] |
Lung Cancer | Correlation of the expression of VEGF with tumor size. | [98] |
 | Patients with higher serum VEGF levels had lower survival compared to patients with lower VEGF levels. | [96, 100-103] |