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Table 2 Immunofluorescence for 5-LO pathway enzymes and LT receptors in fibroblasts from normal and asthmatic donors.

From: Human bronchial fibroblasts express the 5-lipoxygenase pathway

Enzyme/Receptor

Normal*(Mean MFI ± SEM n = 5)

Asthmatic (Mean MFI ± SEM n = 5)

5-LO

9.7 ± 2.8

8.5 ± 3.1

FLAP

12.3 ± 3.8

10.5 ± 4.5

LTA 4 H

7.8 ± 1.9

8.6 ± 3.7

LTC 4 S

0.97 ± 0.4

2.1 ± 1.4

BLT1

10.5 ± 3.1

6.7 ± 3.6

CysLT 1

7.9 ± 1.4

5.5 ± 2.4

  1. * Fibroblasts from 5 normal subjects and 5 asthmatic patients were stained with specific antibodies to 5-LO, FLAP, LTA4H, LTC4S, BLT1 and CysLT1R before analysis by flow cytometry.
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Respiratory Research

ISSN: 1465-993X

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