Figure 4
From: Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-β
Cat K expression is higher in pulmonary macrophages and fibroblasts from silica-treated mice. Quantification of Cat K mRNA in pulmonary cells from C57BL/6 mice instilled with PBS (control) or silica. (A) Cat K expression in a pool of BAL leukocytes collected from 20 control mice and 10 silica-treated mice for each time point. (B) Cat K expression in adherent BAL cells (macrophages) collected 1 month after instillation of 40 control mice and 30 mice administered with silica. (C) Cat K expression in lung fibroblasts recovered 2 months after instillation from a pool of 9 control mice and 8 silica-treated mice. The results are representative of 3 independent experiments. (A), (B), (C) Values were measured 3 times for each condition and are presented as means ± SEM.