Figure 2
From: Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-β
Pulmonary overexpression of Cat K is specific to a fibrotic response of the lung. Quantification of Cat K transcripts in lung tissue from NMRI mice instilled with PBS (control), WC (non-inflammatory model, NI), MnO2 (resolutive alveolitis model, RA) or silica (fibrosing alveolitis model, FA) 1 month after instillation. Values of 4 mice in each group are presented as means ± SEM. * P < 0.05 compared to control values.