Figure 11

Histological appearance ofDBA/2lungs 4 and 6 months after chronic cigarette smoke exposure. Lung parenchyma from smoke-exposed DBA/2 mice, at 4 (A) and 6 months (B). The first foci of subpleural fibrosis are seen from 4 months of smoke exposure (A). After 6 months of cigarette smoke exposure, disseminated foci of severe emphysema and evident areas of subpleural fibrosis are present (B). (A) and (B): Hematoxylin-eosin stain, Scale bars represent 25 μm and 400 μm. respectively.