Table 1 Positional candidate genes from linkage analysis of pulmonary tolerance to BAL protein following repeated ZnO exposure.
From: Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice
Chromosome | QTL Interval | Location | Human Orthology | Candidate Gene |
|---|---|---|---|---|
Chr 1 | 92–112 cM | 94.0 cM | 1 (q21-q22) | Dfy, Duffy blood group |
| Â | Â | 98.0 cM | 1 (q41-q42) | Tlr5, toll-like receptor 5 |
| Â | Â | 98.6 cM | 1 (q41-q42) | Adprt1, ADP-ribosyltransferase 1 |
|  |  | 101.5 cM | 1 (q41) | Tgfb2, transforming growth factor-β2 |
| Â | Â | 105.0 cM | 1 (q32) | Traf5, TNF receptor-associated factor 5 |
| Â | Â | 106.0 cM | 1 (q32-q41) | Slc30a1, solute carrier family 30 (zinc transporter), member 1 |
Chr 4 | 62–82 cM | 62.4 cM | 1 (p35-p34.3) | Ptafr, platelet-activating factor receptor |
| Â | Â | 65.7 cM | 1 (p35.3) | Slc30a2, solute carrier family 30, member 2 |
| Â | Â | 68.0 cM | 1 (p35), 1 (p34-p36) | Pla2g2a, 2c, 2d-f, 5, phospholipase A2 groups |
| Â | Â | 75.5 | 1 (p36.3-p36.2), 1 (p36) | Tnfrsf1b, 8, 9, TNF-receptor superfamily members |
| Â | Â | 79.4 cM | 1 (p36) | Tnfrsf4, TNF-receptor superfamily, member 4 |
Chr 5 | 1–20 cM | 14.0 cM | 7 (q35-q36) | Slc4a2, solute carrier family 4, member 2 |
| Â | Â | 17.0 cM | 7 (p21) | Il6, interleukin 6 |
| Â | Â | 18.0 cM | 7 (pter-qter) | Slc30a3, solute carrier family 30 (zinc transporter), member 3 |