Table 4 Relative risk of annual worsening of GOLD 2013 categories using univariate and multivariate logistic binary regression modeling

Age

1.032

1.004-1.062

0.027

Gender (female)

1.542

0.761-3.122

0.229

Active smoking

1.086

0.637-1.853

0.761

BMI

1.021

0.983-1.060

0.280

Inhaled β2-agonist

0.824

1.487-1.393

0.470

Inhaled anticholinergic

0.905

0.529-1.550

0.717

Inhaled corticosteroid

1.065

0.639-1.774

0.809

Charlson index

1.047

0.898-1.220

0.557

Anxiety

1.021

0.967-1.077

0.450

Depression

1.096

1.027-1.170

0.006

FEV1%*

1.065

1.034-1.096

<0.001

mMRC*

1.956

1.494-2.562

<0.001

CAT*

1.162

1,106-1.221

<0.001

Exacerbations ≥2 or hospitalization ≥1*

0.981

0.182-5.285

0.982

BODE index*

2.136

1.664-2.742

<0.001

Multivariate analysis

Relative risk

95%CI

p

CAT

1.138

1.074-1.206

<0.001

BODE index

2.012

1.487-2.722

<0.001