Genes overexpressed in SSc-ILD vs. Control | Probe set ID | Control mean | SSc-ILD mean | Fold change | p value |
---|---|---|---|---|---|
Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 208937_s_at | 25.5 | 917.5 | 36.1 | 0.00078 |
Interleukin 11 | 206924_at | 23.6 | 717.8 | 30.4 | 0.015 |
Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 207826_s_at | 27.7 | 603.2 | 21.8 | 0.00051 |
Tetraspanin 13 | 217979_at | 37.9 | 533.9 | 14.1 | 0.0033 |
Elastin | 212670_at | 43.7 | 396.9 | 9.1 | 0.0021 |
Xylosyltransferase I | 213725_x_at | 29.0 | 255.4 | 8.8 | 0.0024 |
Serpin peptidase inhibitor, clade E, member 1 | 202628_s_at | 329.8 | 2473.2 | 7.5 | 0.0022 |
Basic helix-loop-helix family, member e40 | 201170_s_at | 44.3 | 256.1 | 5.8 | 0.0014 |
Connective tissue growth factor | 209101_at | 467.9 | 2637.1 | 5.6 | 0.00068 |
Solute carrier family 7, member 5 | 201195_s_at | 56.1 | 294.2 | 5.3 | 0.00022 |
Tropomyosin 1 (alpha) | 206116_s_at | 317.5 | 1619.6 | 5.1 | 0.0032 |
Phosphoribosyl pyrophosphate synthetase 1 | 208447_s_at | 59.0 | 283.4 | 4.8 | 0.0036 |
Inhibin, beta A | 210511_s_at | 143.3 | 688.1 | 4.8 | 0.0012 |
Growth arrest and DNA-damage-inducible, beta | 207574_s_at | 68.1 | 306.6 | 4.5 | 0.0023 |
Coiled-coil domain containing 99 | 221685_s_at | 85.1 | 373.3 | 4.4 | 0.0018 |
Cadherin 2, type 1, N-cadherin (neuronal) | 203440_at | 105.3 | 433.0 | 4.1 | 0.00095 |
Desmoplakin | 200606_at | 80.5 | 306.1 | 3.8 | 0.0016 |
Insulin-like growth factor binding protein 3 | 212143_s_at | 408.6 | 1489.1 | 3.6 | 0.0068 |
Microtubule associated monoxygenase, calponin and LIM domain containing 2 | 212473_s_at | 184.7 | 667.5 | 3.6 | 0.0039 |
Prostaglandin-endoperoxide synthase 1 | 215813_s_at | 102.4 | 362.0 | 3.5 | 0.0083 |
Genes underexpressed in SSc-ILD vs. Control | Probe set ID | Control mean | SSc-ILD mean | Fold change | p value |
Chemokine (C-X-C motif) ligand 10 | 204533_at | 771.2 | 19.2 | −40.1 | 0.00034 |
Chemokine (C-X-C motif) ligand 11 | 210163_at | 179.9 | 5.0 | −36.0 | 0.0027 |
Flavin containing monooxygenase 2 (non-functional) | 211726_s_at | 530.4 | 15.7 | −33.7 | 0.017 |
Interferon-induced protein with tetratricopeptide repeats 2 | 217502_at | 707.1 | 26.1 | −27.1 | 0.0096 |
Vascular cell adhesion molecule 1 | 203868_s_at | 835.2 | 32.2 | −26.0 | 0.0049 |
Bone marrow stromal cell antigen 2 | 201641_at | 315.8 | 12.5 | −25.3 | 0.0081 |
Radical S-adenosyl methionine domain containing 2 | 213797_at | 333.8 | 13.3 | −25.1 | 0.0039 |
Interferon-induced protein 44-like | 204439_at | 370.7 | 15.4 | −24.1 | 0.00033 |
Interferon-induced protein with tetratricopeptide repeats 1 | 203153_at | 1744.2 | 82.6 | −21.1 | 0.000039 |
2’,5’-oligoadenylate synthetase 1, 40/46 kDa | 205552_s_at | 374.6 | 18.3 | −20.5 | 0.0014 |
Complement factor B | 202357_s_at | 837.0 | 42.6 | −19.6 | 0.0036 |
Interferon-induced protein with tetratricopeptide repeats 3 | 204747_at | 985.0 | 61.9 | −15.9 | 0.00031 |
Chromosome 10 open reading frame 10 | 209183_s_at | 208.8 | 13.6 | −15.3 | 0.0062 |
Myxovirus resistance 1, interferon-inducible protein p78 (mouse) | 202086_at | 1361.9 | 91.2 | −14.9 | 0.00012 |
Receptor (chemosensory) transporter protein 4 | 219684_at | 196.4 | 13.3 | −14.8 | 0.000091 |
Chemokine (C-C motif) ligand 11 | 210133_at | 529.8 | 36.2 | −14.6 | 0.0021 |
Retinoic acid receptor responder (tazarotene induced) 3 | 204070_at | 239.4 | 17.2 | −13.9 | 0.00024 |
Alcohol dehydrogenase 1B (class I), beta polypeptide | 209613_s_at | 268.9 | 19.8 | −13.6 | 0.011 |
Secreted and transmembrane 1 | 213716_s_at | 285.0 | 22.0 | −13.0 | 0.0012 |
Interferon, alpha-inducible protein 6 | 204415_at | 1196.6 | 93.7 | −12.8 | 0.00043 |
Genes overexpressed in IPF vs. Control | Probe set ID | Control mean | IPF mean | Fold change | p value |
Interleukin 11 | 206924_at | 23.6 | 2374.9 | 100.6 | 0.0019 |
Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 208937_s_at | 25.5 | 752.8 | 29.6 | 0.011 |
Tetraspanin 13 | 217979_at | 37.9 | 1039.1 | 27.4 | 0.0052 |
NADPH oxidase 4 | 219773_at | 12.3 | 323.6 | 26.4 | 0.016 |
Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 207826_s_at | 27.7 | 603.4 | 21.8 | 0.0025 |
Phospholamban | 204939_s_at | 25.7 | 460.1 | 17.9 | 0.035 |
Elastin | 212670_at | 43.7 | 766.9 | 17.6 | 0.0026 |
Xylosyltransferase I | 213725_x_at | 29.0 | 443.6 | 15.3 | 0.034 |
Galanin prepropeptide | 214240_at | 18.4 | 254.4 | 13.8 | 0.014 |
Cytokine receptor-like factor 1 | 206315_at | 23.4 | 319.3 | 13.6 | 0.0098 |
Calponin 1, basic, smooth muscle | 203951_at | 83.0 | 1048.0 | 12.6 | 0.0024 |
Follistatin-like 3 | 203592_s_at | 32.5 | 404.8 | 12.4 | 0.0048 |
CTP synthase | 202613_at | 39.5 | 454.7 | 11.5 | 0.000059 |
Endothelial cell-specific molecule 1 | 208394_x_at | 10.2 | 116.8 | 11.4 | 0.031 |
Cadherin 6, type 2, K-cadherin (fetal kidney) | 210602_s_at | 26.2 | 298.4 | 11.4 | 0.00092 |
Proenkephalin | 213791_at | 33.7 | 366.7 | 10.9 | 0.00086 |
Adhesion molecule with Ig-like domain 2 | 222108_at | 54.7 | 490.6 | 9.0 | 0.025 |
NUAK family, SNF1-like kinase, 1 | 204589_at | 56.2 | 489.9 | 8.7 | 0.001 |
Tropomyosin 1 (alpha) | 206117_at | 30.9 | 261.7 | 8.5 | 0.0069 |
Inhibin, beta A | 210511_s_at | 143.3 | 1198.5 | 8.4 | 0.0023 |
Genes underexpressed in IPF vs. Control | Probe set ID | Control mean | IPF mean | Fold change | p value |
Interferon-induced protein with tetratricopeptide repeats 1 | 203153_at | 1744.2 | 5.4 | −321.4 | 0.000033 |
Myxovirus resistance 1, interferon-inducible protein p78 (mouse) | 202086_at | 1361.9 | 8.8 | −154.1 | 0.000096 |
Interferon, alpha-inducible protein 6 | 204415_at | 1196.6 | 11.8 | −101.2 | 0.00027 |
Chemokine (C-X-C motif) ligand 10 | 204533_at | 771.2 | 9.5 | −81.3 | 0.00031 |
Superoxide dismutase 2, mitochondrial | 221477_s_at | 2180.4 | 29.8 | −73.2 | <0.000001 |
Myxovirus resistance 2 (mouse) | 204994_at | 517.3 | 8.5 | −60.6 | 0.00062 |
Interferon induced transmembrane protein 1 (9–27) | 214022_s_at | 3698.0 | 61.4 | −60.3 | <0.000001 |
Interferon-induced protein with tetratricopeptide repeats 3 | 204747_at | 985.0 | 17.2 | −57.2 | 0.00023 |
Pentraxin 3, long | 206157_at | 1415.2 | 35.2 | −40.2 | 0.000016 |
Interferon-induced protein 44-like | 204439_at | 370.7 | 11.6 | −31.9 | 0.0003 |
Complement component 3 | 217767_at | 457.9 | 14.4 | −31.8 | 0.000072 |
KIAA1199 | 212942_s_at | 799.0 | 30.8 | −26.0 | 0.00027 |
Interferon-induced protein 35 | 209417_s_at | 455.6 | 18.1 | −25.1 | 0.000062 |
Chemokine (C-X-C motif) ligand 1 | 204470_at | 637.1 | 26.3 | −24.2 | <0.000001 |
Growth arrest-specific 1 | 204457_s_at | 383.2 | 17.2 | −22.3 | 0.000059 |
Signal transducer and activator of transcription 1, 91 kDa | 209969_s_at | 327.3 | 15.3 | −21.4 | 0.000097 |
Chemokine (C-C motif) ligand 2 | 216598_s_at | 2676.4 | 128.3 | −20.9 | 0.00003 |
Interferon-induced protein 44 | 214453_s_at | 335.0 | 17.0 | −19.7 | 0.000027 |
Caspase 1 (interleukin 1, beta, convertase) | 211367_s_at | 180.6 | 10.0 | −18.1 | <0.000001 |
Tumor necrosis factor, alpha-induced protein 2 | 202510_s_at | 404.2 | 22.6 | −17.9 | 0.000003 |