Skip to main content

Table 3 The inhibitory effect of 10-6 M methylprednisolone (MP) alone and in combination with 2.5 ng/mL Cyclosporin A (CsA) on IFNγ and TNFα expression by Pgp1+ T, NKT-like and NK cells are shown (mean ± SEM)

From: The drug efflux pump Pgp1 in pro-inflammatory lymphocytes is a target for novel treatment strategies in COPD

 

IFNγ

TNFα

Drug

Dose

T

NKT

NK

T

NKT

NK

MP

10-6 M

2 ± 2*

4 ± 3

45 ± 9

3 ± 2

5 ± 2

49 ± 9

CsA

2.5 ng/ml

50 ± 10

46 ± 8

89 ± 7

54 ± 6

27 ± 6

87 ± 7

MP + CsA

10-6 M + 2.5 ng/ml

81 ± 5

76 ± 8

96 ± 7

78 ± 7

72 ± 8

97 ± 9

  1. The combination of 10-6 M methylprednisolone and 2.5 ng/mL Cyclosporin A resulted in the synergistic inhibition of IFNγ and TNFα expression by Pgp1+ T and NKT-like cells.
  2. * The percentage inhibition of IFNγ and TNFα by Pgp1+ T, NKT-like and NK cells compared with control (same specimen) without drug/s.
Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us