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Table 2 Baseline characteristics of patients (pre-matching cohort)

From: Long-acting beta-agonists reduce mortality of patients with severe and very severe chronic obstructive pulmonary disease: a propensity score matching study

 

All patients

Comparison of LABA (+) and (−) cohorts

  

LABA (−)

LABA (+)

P

N

591

292

299

 

Age (year)

66.6 ± 5.3

66.9 ± 5.2

66.4 ± 5.3

0.208

Sex (female)

209 (35.4%)

93 (31.8%)

116 (38.8%)

0.074

Race (not white)

33 (5.6%)

20 (6.8%)

13.0 (4.3%)

0.185

Annual income < 30000 $

304 (51.4%)

155 (53.1%)

149 (49.8%)

0.429

FEV1 (%predicted)

26.7 ± 7.1

26.8 ± 7.1

26.7 ± 7.0

0.780

FEV1 (mL)

777 ± 240

782 ± 237

772 ± 243

0.456

FEV1/FVC (%)

31.2 ± 6.3

30.9 ± 6.0

31.5 ± 6.6

0.358

FVC (%predicted)

67.2 ± 15.1

68.0 ± 15.3

66.5 ± 14.9

0.346

FVC (mL)

2545 ± 782

2582 ± 772

2509 ± 791

0.225

Forced residual capacity (mL)

6042 ± 1311

6111 ± 1323

5975 ± 1298

0.243

Hb adjusted DLCO

8.1 ± 3.1

8.1 ± 3.0

8.0 ± 3.1

0.761

Peak pulmonary arterial pressure (mmHg)

33.7 ± 6.2 (N = 502)

34.2 ± 6.1 (N = 252)

33.3 ± 6.3 (N = 250)

0.110

Hemoglobin (g/dL)

14.4 ±1.3

14.4 ± 1.2

14.3 ± 1.3

0.905

PaO2 (mmHg)

64.2 ± 10.0

64.0 ±10.0

64.4 ± 10.0

0.838

PaCO2 (mmHg)

43.1 ± 5.8

43.6 ± 6.1

42.6 ± 5.4

0.083

Area of emphysema (%)

16.1 ± 10.6 (N = 532)

15.7 ± 11.1 (N = 259)

16.4 ± 10.2 (N = 273)

0.228

Body mass index (kg/m^2)

24.7 ± 3.5

24.7 ± 3.6

24.8 ± 3.5

0.503

Six-minute walk distance

368 ± 96

366 ± 95

370 ± 98

0.562

St. George respiratory questionnaire

53.6 ± 12.7

54.1 ± 12.6

53.1 ± 12.7

0.394

Shortness of breath questionnaire

63.3 ± 18.5

63.8 ± 18.1

62.7 ± 18.9

0.483

Beck depression inventory

9.3 ± 5.9

9.2 ± 5.8

9.3 ± 5.9

0.650

Recent emergency visit

75 (12.7%)

38 (13.0%)

37 (12.4%)

0.816

Recent hospital stay

48 (8.1%)

26 (8.9%)

22 (7.4%)

0.492

LTOT during sleep

414 (70.1%)

206 (70.5%)

208 (69.6%)

0.794

LTOT on exertion

465 (78.7%)

233 (79.8%)

232 (77.6%)

0.513

Oral corticoid

153 (25.9%)

76 (26.0%)

77 (25.8%)

0.939

Inhaled corticosteroid

447 (75.6%)

211 (72.3%)

236 (78.9%)

0.059

Short-acting beta-agonist

515 (87.1%)

264 (90.4%)

251 (83.9%)

0.019

Anticholinergic agent

486 (82.2%)

242 (82.9%)

244 (81.6%)

0.686

Theophylline

238 (40.3%)

124 (42.5%)

114 (38.1%)

0.282

Diuretics

86 (14.6%)

41 (14.0%)

45 (15.1%)

0.728

  1. Parameters were compared with Wilcoxon rank sum test or Chi-square test.
  2. LABA: long-acting beta-agonist.
  3. FEV1: forced expiratory volume in one second.
  4. FVC: forced vital capacity.
  5. Hb adjusted DLCO: hemoglobin adjusted diffusing capacity of the lung for carbon monoxide.
  6. PaO2: pressure of oxygen in artery.
  7. PaCO2: pressure of carbon dioxide in artery.
  8. LTOT: long-term oxygen therapy.
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Respiratory Research

ISSN: 1465-993X

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