Figure 4
From: M2 macrophage polarisation is associated with alveolar formation during postnatal lung development
Alveolar development is associated with M2 macrophage polarisation. qPCR assessment of gene expression indicative of different macrophage polarisation states. Expression of pro-inflammatory M1 (A-C) and remodelling M2 (D-F) genes were normalised against β-actin expression and presented as relative quantification (RQ) compared to P1. All genes displayed on the same axis demonstrate the upregulation in M2 markers during alveolarisation (G). n=4 littermate lungs/time point. ‘a’ represents significant difference compared to P1, ‘b’ compared to P3, ‘c’ compared to P5, ‘d’ compared to P7. ‘e’ compared to P14, ‘f’ compared to P21. Asterisks following letters represent level of significance, where *=p<0.05, **=p<0.01, ***=p<0.01.