Table 6 Clinical features of subjects stratified by the median neutrophil count (%) and RB1 luminal area
From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma
| Â | Low neutrophil, Low luminal area | High neutrophil, Low luminal area | Low neutrophil, High luminal area | High neutrophil, High luminal area | p value |
|---|---|---|---|---|---|
N | 13 | 16 | 14 | 16 | Â |
Male | 4 | 10 | 4 | 7 | 0.22 |
Current age | 52 (3) | 54 (3) | 44 (3) | 46 (3) | 0.14 |
Age of onset | 35 (4) | 31 (4) | 25 (4) | 20 (4) | 0.16 |
BMI, kg/m2 | 32.8 (1.7) | 32.4 (1.8) | 24.9 (1.4) | 29.1 (0.8) | <0.001 |
Habitual smokers and ex smokers with >10 py | 4 | 6 | 2 | 1 | 0.86 |
Pack years history | 7 (3) | 15 (8) | 6.5 (4) | 4 (3) | 0.48 |
Severe Exacerbations | 1.5 | 2 | 2 | 4 | 0.05 |
IgE | 266 | 212 | 174 | 141 | 0.38 |
ACQ6 | 2.11 (0.24) | 2.29 (0.24) | 1.98 (0.30) | 2.29 (0.28) | 0.82 |
Subjects taking oral corticosteroids | 7 | 7 | 4 | 7 | 0.84 |
Daily predinosolone dose, mg | 6.9 (2) | 3.9 (1.2) | 3.0 (1.4) | 3.4 (1.3) | 0.30 |
Pre Bronchodilator FEV1 | 2.15 (0.32) | 2.21 (0.2) | 2.29 (0.19) | 2.39 (0.25) | 0.90 |
Pre Bronchodilator FEV1 % predicted | 2.29 (0.31) | 2.37 (0.22) | 2.47 (0.2) | 2.53 (0.24) | 0.90 |
Bronchodilator reversibility, ml | 0.14 (0.02) | 0.42 (0.25) | 0.18 (0.05) | 0.14 (0.04) | 0.44 |
Pre Bronchodilator FVC | 3.07 (0.37) | 3.18 (0.27) | 3.37 (0.2) | 3.40 (0.31) | 0.84 |
Pre Bronchodilator FVC | 3.17 (0.37) | 3.36 (0.28) | 3.44 (0.2) | 3.41 (0.31) | 0.92 |
Pre Bronchodilator FEV1 % of predicted | 74.8 (8.9) | 73.9 (5.7) | 76.1 (4.5) | 75.9 (5.3) | 0.99 |
Post Bronchodilator FEV1 % of predicted | 79.7 (8.4) | 77.4 (6.2) | 82.8 (4) | 83.4 (4.9) | 0.87 |
BD Bronchodilator Reversibility % FEV1 | 4.8 (1.1) | 4.7 (1.1) | 6.7 (1.8) | 7.4 (2.8) | 0.68 |
Pre Bronchodilator FEV1/FVC ratio | 69.2 (4.4) | 70 (3.3) | 68.7 (3.2) | 70.1 (4.3) | 0.99 |
Post Bronchodilator FEV1/FVC ratio | 71.4 (4.3) | 70.1 (2.8) | 72.9 (2.8) | 74 (4.2) | 0.87 |
Total Cells | 0.45 [0.16-1.2] | 0.80 [0.45-1.4] | 0.37 [0.17-0.80] | 0.8 [0.4-1.5] | 0.74 |
Neutrophils % | 33.6 [18–62.7] | 85.2 [79–91.1] | 40.7 [30.9-53.6] | 83.9 [78.9-89.6] | <0.001 |
Eosinophils % | 2.7 [1–7.4] | 1.9 [0.7-4.5] | 3.7 [1.5-9.3] | 1.4 [0.6-3.2] | 0.32 |
Bronchiectasis present | 2 (15) | 7 (44) | 5 (36) | 9 (60) | 0.15 |
Bronchial Wall Thickening present | 10 (77) | 12 (75) | 8 (57) | 9 (60) | 0.59 |
Lumen area/Body Surface Area (mm2/m2) | 3.4 (0.2) | 3.1 (0.2) | 7.0 (0.6) | 7.6 (0.4) | <0.001 |
Total area/Body Surface Area (mm2/m2) | 13.1 (0.5) | 13.31 (1.1) | 21.3 (1.5) | 23.1 (1.4) | <0.001 |