From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma
 | Low neutrophil, Low total area | High neutrophil, Low total area | Low neutrophil, High total area | High neutrophil, High total area | p value |
---|---|---|---|---|---|
Factor VII* | 2.19 [1.59-3.01] | 1.88 [1.5-2.37] | 2.06 [1.51-2.83] | 2.41 [1.89-3.07] | 0.61 |
Fibrinogen* | 271 [165–442] | 249 [103–602] | 94 [60–148] | 430 [220–830] | 0.002 |
Ferritin* | 2.28 [1.06-4.88] | 2.93 [1.63-5.26] | 1.74 [0.99-3.07] | 2.11 [0.79-5.66] | 0.5 |
IL-1 α | 38 [18–79] | 43 [29–64] | 13 [7–24] | 28 [14–58] | 0.001 |
IL-1 β | 34.6 [17.4-69] | 56.6 [23.7-135] | 15.8 [8.87-28.2] | 117 [47–290] | 0.005 |
IL-1RA | 8249 [3792–17942] | 8053 [4281–15148] | 4341 [2370–7952] | 7599 [4441–13002] | 0.39 |
IL-6 | 40.7 [20.1-82.6] | 26.1 [12.3-55.5] | 41 [23.3-72.3] | 62.7 [35.1-112] | 0.27 |
IL-8 | 3469 [1790–6726] | 2365 [865–6646] | 3857 [2088–7124] | 5138 [2186–12076] | 0.54 |
IL-15 | 390 [260–600] | 430 [290–670] | 410 [250–670] | 500 [360–700] | 0.43 |
IL-18 | 35 [22–57] | 38 [23–64] | 34.7 [22.6-53.5] | 50.3 [30.8-82] | 0.32 |
TNF-α | 4.64 [3.47-6.2] | 4.7 [2.21-9.99] | 5.8 [3.74-9] | 10.5 [4.67-23.7] | 0.07 |
TNFR2 | 340 [140–830] | 240 [100–560] | 240 [130–460] | 540 [230–1230] | 0.54 |
CCL2 | 153 [92–256] | 62.2 [31–124] | 104 [53–205] | 10 6[62–181] | 0.079 |
CCL4 | 380 [225–640] | 380 [165–877] | 866 [299–2508] | 414 [174–983] | 0.096 |
CCL11 | 56 [39.5-79.4] | 41.2 [32.3-52.4] | 137 [72–261] | 54.6 [36.1-82.5] | 0.0047 |
MMP-3* | 0.29 [0.14-0.57] | 0.25 [0.14-0.42] | 0.20 [0.11-0.36] | 0.26 [0.16-0.43] | 0.58 |
MMP-9* | 41.3 [15.5-110] | 55.7 [29.9-103] | 11.6 [7.16-19] | 65.8 [36–120] | 0.17 |
TIMP-1* | 153 [104–225] | 58 [23–145] | 139 [74–226] | 114 [62–210] | 0.25 |
ICAM-1 | 4050 [2250–7280] | 1520 [930–2510] | 4800 [2220–10600] | 2600 [1570–4320] | 0.017 |
VCAM-1 | 1400 [690–2820] | 1080 [670–1750] | 1020 [440–2350] | 1040 [670–1630] | 0.47 |
VEGF | 1109 [799–1539] | 579 [370–907] | 903 [551–1481] | 865 [542–1381] | 0.061 |