Table 4 Clinical features of subjects stratified by the median neutrophil count (%) and RB1 total area
From: Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma
| Â | Low neutrophil, Low total area | High neutrophil, Low total area | Low neutrophil, High total area | High neutrophil, High total area | p value |
|---|---|---|---|---|---|
N | 14 | 15 | 13 | 17 | Â |
Male, n | 5 | 9 | 3 | 8 | 0.24 |
Current age | 52 (3) | 54 (3) | 44 (4) | 47 (3) | 0.15 |
Age of onset | 36 (5) | 31 (5) | 24 (5) | 20 (4) | 0.08 |
BMI, kg/m2 | 32.7 (1.6) | 32 (2) | 24.4 (1.4) | 29.7 (0.8) | 0.002 |
Habitual and ex smokers with >10 pack year history | 4 | 5 | 2 | 2 | 0.95 |
Pack years history | 6.5 (3) | 14.5 (9) | 7 (4) | 5 (3) | 0.59 |
Severe Exacerbations | 1.5 (0.5) | 2.5 (0.4) | 2.5 (0.6) | 4 (0.6) | 0.01 |
IgE | 208 | 221 | 270 | 119 | 0.28 |
ACQ6 | 2.2 (0.25) | 2.2 (0.26) | 1.9 (0.31) | 2.3 (0.27) | 0.68 |
Subjects taking oral corticosteroids, n | 7 | 8 | 4 | 6 | 0.87 |
Daily Predinsolone dose, mg | 6 (1.9) | 5.5 (1.6) | 3 (1.5) | 2 (0.7) | 0.14 |
Pre Bronchodilator FEV1 | 2.21 (0.3) | 2.29 (0.2) | 2.24 (0.2) | 2.31 (0.25) | 0.99 |
Post Bronchodilator FEV1 | 2.36 (0.3) | 2.48 (0.2) | 2.41 (0.2) | 2.42 (0.25) | 0.98 |
Bronchodilatorreversibility, mls | 0.15 (0.03) | 0.46 (0.2) | 0.17 (0.06) | 0.11 (0.04) | 0.28 |
Pre Bronchodilator FVC | 3.12 (0.3) | 3.31 (0.2) | 3.33 (0.2) | 3.26 (0.32) | 0.96 |
Post Bronchodilator FVC | 3.24 (0.3) | 3.49 (0.2) | 3.39 (0.2) | 3.28 (0.32) | 0.92 |
Pre Bronchodilator FEV1 % of predicted | 74.4 (8.2) | 77.6 (5.6) | 76.7 (4.9) | 74.1 | 0.93 |
Post Bronchodilator FEV1 % of predicted | 79.4 (7.8) | 82.1 (6.2) | 83.4 (4.3) | 83.8 | 0.94 |
Bronchodilator Reversibility % FEV1 | 5.03 (1.1) | 5.8 (1.3) | 6.7 (1.9) | 5.5 (1.6) | 0.94 |
Pre Bronchodilator FEV1/FVC ratio | 69.8 (4.1) | 69.8 (3.5) | 68 (3.3) | 70.3 (4.1) | 0.97 |
Post Bronchodilator BD FEV1/FVC ratio | 72.1 (4) | 70.7 (3.1) | 72.9 | 73.2 (4) | 0.96 |
Total Cells | 0.53 [0.2-1.43] | 0.7 [0.41-1.4] | 0.31 [0.15-0.63] | 0.82 [0.4-1.4] | 0.79 |
Neutrophils % | 35 [19.6-62.5] | 86 [80.5-91.9] | 39.5 [29.5-52.5] | 83.8 [78.4-88.6] | <0.001 |
Eosinophils % | 2.8 [1.1-7] | 2.2 [0.9-9.3] | 3.7 [1.4-10.8] | 1.2 [0.2-2.7] | 0.16 |
Bronchiectasis present n (%) | 2 (14) | 5 (33) | 5 (38) | 11 (65) | 0.03 |
Bronchial Wall Thickening present | 10 (70) | 11 (73) | 8 (62) | 10 (63) | 0.87 |
Lumen area/Body Surface Area (mm2/m2) | 3.6 (0.26) | 3.3 (0.35) | 7.1 (0.66) | 7.2 (0.58) | <0.001 |
Total area/Body Surface Area (mm2/m2) | 13.3 (0.54) | 12.1 (0.67) | 21.8 (1.64) | 23.6 (1.27) | <0.001 |