From: Strain variation in response to lung ischemia: role of MMP-12
B6 | D2 | ||||
---|---|---|---|---|---|
3d LPAL | 14d LPAL | Naïve | 3d LPAL | 14d LPAL | |
Structural genes | |||||
Col1a1 | 1.3 ± 0.1 | 1.4 ± 0.2 | 1.1 ± 0.1 | 2.1 ± 0.6 | 1.6 ± 0.2 |
Col3a1 | 1.4 ± 0.0 | 1.2 ± 0.2 | 1.6 ± 0.0 | 1.7 ± 0.1 | 1.7 ± 0.2 |
Col6a3 | 1.3 ± 0.1 | 1.7 ± 0.2 | 1.1 ± 0.2 | 1.7 ± 0.4 | 2.2 ± 0.5 |
Eln | 1.8 ± 0.2 | 3.0 ± 0.5* | 0.5 ± 0.1* | 2.4 ± 0.8 | 3.5 ± 0.5* |
Fbn1 | 1.1 ± 0.2 | 1.1 ± 0.1 | 0.9 ± 0.1 | 2.2 ± 1.0 | 1.4 ± 0.1 |
Fn1 | 1.3 ± 0.1 | 1.3 ± 0.2 | 1.3 ± 0.3 | 1.5 ± 0.2 | 1.3± 0.1 |
Protease genes | |||||
MMP-2 | 1.0 ± 0.1 | 1.9 ± 0.2* | 20.1 ± 1.0* | 0.9 ± 0.2 | 1.5 ± 0.1 |
MMP-9 | 1.3 ± 0.2 | 0.5 ± 0.2 | 0.9 ± 0.1 | 1.3 ± 0.3 | 0.4 ± 0.0* |
MMP-12 | 3.6 ± 0.7* | 1.7 ± 0.1 | 3.2 ± 0.5* | 2.0 ± 0.8 | 2.9 ± 1.2 |
MMP-14 | 2.0 ± 0.1* | 1.5 ± 0.2 | 1.0 ± 0.1 | 2.7 ± 0.8 | 2.0 ± 0.3 |
Ctsk | 1.3 ± 0.1 | 1.8 ± 0.3 | 1.6 ± 0.1 | 1.1 ± 0.2 | 1.7 ± 0.2 |
Anti-protease genes | |||||
Timp1 | 8.8 ± 0.6* | 1.5 ± 0.2 | 0.8 ± 0.0 | 19.6 ± 2.9* | 3.8 ± 0.1* |
Timp2 | 0.7 ± 0.1 | 0.9 ± 0.0 | 1.5 ± 0.1 | 0.8 ± 0.2 | 1.5 ± 0.1 |
Timp3 | 0.7 ± 0.1 | 1.0 ± 0.0 | 1.7 ± 0.2 | 1.1 ± 0.3 | 2.4 ± 0.2* |
Timp4 | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 1.2 ± 0.1 | 2.5 ± 0.4* |