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Table 2 Linear slope estimates (± SE) for the annual change (year 1-5) in pre- and post-bronchodilator FEV 1 (ml/yr) both unadjusted and adjusted for covariates (age, gender, cigarettes/day and log of the 2-point methacholine-FEV 1 response slope) by intervention group

From: Comparison of the variability of the annual rates of change in FEV1 determined from serial measurements of the pre- versus post-bronchodilator FEV1 over 5 years in mild to moderate COPD: Results of the lung health study

Group

Unadjusted

Adjusted

 

Slope Estimate ml/yr

SE ml/yr

p†

Slope Estimate ml/yr

SE ml/yr

p†

UC (N = 1477)

Pre-bronchodilator

−56.7

1.36

 

−56.7

1.37

 

Post-bronchodilator

−52.8

1.25

 

−53.1

1.26

 

Difference*

3.9

1.07

<0.001

3.6

1.08

<0.001

SIP (N = 1503)

Pre-bronchodilator

−43.2

1.30

 

−43.3

1.31

 

Post-bronchodilator

−40.6

1.25

 

−40.8

1.27

 

Difference*

2.6

1.07

0.016

2.5

1.09

0.020

SIA (1504)

Pre-bronchodilator

−42.7

1.36

 

−42.7

1.38

 

Post-bronchodilator

−37.5

1.27

 

−37.6

1.29

 

Difference*

5.2

1.22

<0.001

5.1

1.24

<0.001

  1. UC = Usual Care; SIP = Special Intervention Placebo; SIS = Special Intervention Anticholinergic.
  2. *Difference between the linear slope estimates calculated using the pre- versus post-bronchodilator FEV1.
  3. †p values refer to the significance of the differences between the slopes determined from the pre- versus post-bronchodilator FEV1 within each group (mixed model).
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Respiratory Research

ISSN: 1465-993X

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