Longitudinal inspiratory capacity changes in chronic obstructive pulmonary disease

Respiratory Research

Table 3 Annual rates of decline in pre-/post-bronchodilator IC, FEV ₆ , and SVC over 4 years ^a

	Tiotropium (mL/year)		Control (mL/year)		Δ Tiotropium–control	p-value
	N	Mean (SE)	N	Mean (SE)	Mean (SE)
Pre-bronchodilator	2910	36 (3)	2864	32 (3)	5 (5)	0.30
Post-bronchodilator	2905	52 (4)	2853	47 (4)	6 (5)	0.28
Pre-bronchodilator	2910	42 (2)	2864	40 (2)	2 (3)	0.39
Post-bronchodilator	2905	57 (2)	2853	57 (2)	−0 (3)	0.91
Pre-bronchodilator	2531	47 (3)	2374	41 (3)	6 (4)	0.11
Post-bronchodilator	2527	66 (3)	2383	65 (3)	1 (4)	0.79

^aData from SVC previously published [13].
Abbreviations: FEV₆, forced expiratory volume in 6 seconds; IC, inspiratory capacity; SE, standard error; SVC, slow vital capacity.

ISSN: 1465-993X