Figure 2

TRPM2 deficiency has no effect on the LPS-induced BAL inflammation and lung cytokine production. TRPM2-deficient mice (gray bars) or their wild type counterpart (white bars) were challenged with LPS (hatched bars) or saline (plain bars) as described in methods. Animals were killed for bronchoalveolar lavage differential cell counts and lung soluble mediator measurement at 3 and 24 hours post challenge. Data are shown as mean ± SEM of 7-8 animals per group. Significance (P < 0.05), indicated by *, is against the air-exposed mice for each strain. No statistical significance was observed between deficient and wild type animals on all the parameters measured.