From: Cleaved cytokeratin-18 is a mechanistically informative biomarker in idiopathic pulmonary fibrosis
Variable | IPF | HP | NSIP |
---|---|---|---|
 | (n = 84) | (n = 24) | (n = 22) |
Age, years | 70.3 (7.9) | 57.0 (10.3)* | 63.6 (12.5)* |
Male sex, % | 76.2 | 33.3* | 59.1 |
Diagnosis by surgical lung biopsy, % | 50.0 | 66.7 | 72.7 |
Smoking history | Â | Â | Â |
Ever smoked, % | 78.6 | 41.7* | 31.8* |
Pack-years | 27.7 (28.7) | 11.8 (18.8)* | 6.4 (13.8)* |
Measures of disease severity | Â | Â | Â |
Dyspnea score | 9.8 (6.0) | 11.2 (4.6) | 9.6 (4.4) |
Long-term oxygen therapy, % | 20.2 | 23.8 | 27.3 |
Pulmonary function | Â | Â | Â |
FVC, % predicted | 69.4 (18.2) | 67.3 (22.0) | 64.1 (19.1) |
DLCO, % predicted | 46.7 (18.4) | 55.1 (21.2) | 43.7 (14.4) |