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Figure 5 | Respiratory Research

Figure 5

From: The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in aspergillus fumigatus sensitized mice

Figure 5

Lp-PLA 2 deficiency did not increase inflammatory cell influx and airway hyperresponsiveness after allergen challenge of actively sensitized Lp-PLA2-/- mice. (A): 9-12 week-old male C57/B6 wild-type and Lp-PLA2-/- mice were i.p. injected with 20 μg Af pre-formulated with alum (volume 1:1) on day 1 and 7, then intranasally challenged with 30 μg Af on day 13 and studied on day 14 or 15. Mice received Af challenge alone were negative controls. (B): Macrophages, eosinophils, neutrophils, lymphocytes in BAL were counted after cytospin preparations and Giemsa staining. Data are presented as absolute cell number of BAL (mean± sem, n=10-11). Lung resistance (C) and lung dynamic compliance (D) were measured by FlexiVent in response to increasing doses of MCh.

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Respiratory Research

ISSN: 1465-993X

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