From: Epidemiology, radiology, and genetics of nicotine dependence in COPD
SNP (Chr. 15) | CHRNA3/5 | ||||||||
---|---|---|---|---|---|---|---|---|---|
rs8034191 | rs1051730 | ||||||||
FTND score* | Beta | SE | p | Beta | SE | p | |||
Current smokers | Combined (312) | 0.45 | 0.21 | 0.03 | 0.53 | 0.21 | 0.01 | ||
COPD (146) | 0.32 | 0.30 | 0.30 | 0.29 | 0.31 | 0.35 | |||
Control(166) | 0.51 | 0.28 | 0.07 | 0.66 | 0.28 | 0.02 | |||
Log (%emphysema)† | |||||||||
Current smokers | Combined (312) | 0.02 | 0.10 | 0.83 | 0.03 | 0.10 | 0.77 | ||
COPD (146) | -0.005 | 0.15 | 0.98 | 0.01 | 0.15 | 0.93 | |||
Control (166) | 0.06 | 0.10 | 0.58 | 0.03 | 0.11 | 0.76 | |||
Ex-smokers | Combined (681) | 0.14 | 0.07 | 0.047 | 0.14 | 0.07 | 0.049 | ||
COPD (344) | 0.14 | 0.08 | 0.06 | 0.13 | 0.08 | 0.10 | |||
Control (337) | -0.03 | 0.07 | 0.68 | -0.02 | 0.07 | 0.75 | |||
Current and ex-smokers | Combined (985) | 0.11 | 0.06 | 0.06 | 0.12 | 0.06 | 0.05 | ||
COPD (490) | 0.14 | 0.07 | 0.06 | 0.14 | 0.07 | 0.07 | |||
Control (495) | -0.001 | 0.06 | 0.99 | -0.002 | 0.06 | 0.98 |