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Table 4 Genes with at least one significant probe per gene in the human data and at least in one mouse data set (adjusted p-value <0.05)

From: Expression analysis of asthma candidate genes during human and murine lung development

Human gene symbol

Mouse gene symbol

Beta coef.* human

Beta coef.* A/J

Beta coef.* SW

Beta coef.* C57BL6

p-value human data*

p-value A/J†

p-value SW†

p-value C57BL6†

Combined p-value‡

NOD1

Nod1

0.012

-

-

0.133

7.0E-8

-

-

2.1E-2

4.7E-9

EDN1

Edn1

0.026

0.018

0.054

0.138

1.6E-6

7.4E-3

1.4E-3

2.4E-2

3.9E-11

ROBO1

Robo1

-0.009

-0.014

-

-0.055

1.5E-5

3.8E-2

-

9.4E-2

6.9E-7

IL4R

Il4ra

0.01

0.033

0.032

0.1

3.4E-5

3.0E-5

2.3E-2

5.5E-2

5.8E-11

RORA

Rora

0.022

0.01

0.025

0.107

3.5E-5

1.3E-2

9.2E-3

2.1E-2

5.5E-9

PLAUR

Plaur

-0.008

0.013

0.015

0.106

2.0E-4

2.3E-2

5.2E-2

2.1E-2

9.8E-1

CCL5

Ccl5

0.008

0.022

0.027

0.079

2.6E-4

1.6E-7

1.9E-3

2.0E-2

5.5E-13

IRAK3

Irak3

-0.011

-

-

0.073

1.3E-3

-

-

4.5E-2

2.0E-2

IL18

Il18

0.004

0.01

0.018

0.139

1.6E-3

4.4E-4

2.4E-2

2.7E-1

1.3E-7

STAT6

Stat6

0.007

0.021

0.002

0.106

1.8E-3

1.6E-2

6.0E-1

4.7E-2

2.5E-5

CHIA

Chia

0.009

0.077

0.039

0.288

1.8E-3

5.7E-3

3.4E-1

3.3E-2

4.0E-6

HLA-G

H2-M3

0.01

0.021

0.032

0.103

2.6E-3

2.9E-5

9.2E-4

1.7E-2

3.7E-10

CD86

Cd86

0.003

0.001

0.008

0.097

5.6E-3

9.3E-1

1.3E-1

3.1E-2

1.9E-3

PRNP

Prnp

-0.003

0.02

0.031

0.106

8.9E-3

8.8E-3

1.1E-1

7.2E-2

5.0E-1

PCDH1

Pcdh1

0.006

-

-

0.232

1.0E-2

-

-

3.1E-2

1.6E-3

SERPINE1

Serpine1

0.021

0.018

0.02

0.129

1.6E-2

4.5E-5

9.6E-3

1.7E-2

3.3E-8

TNF

Tnf

0.004

-0.003

0.007

0.051

2.3E-2

3.7E-1

2.6E-1

4.9E-2

4.5E-2

TLE4

Tle4

-0.004

-0.009

0.006

-0.07

2.3E-2

1.0E-3

3.1E-1

3.0E-1

1.0E-3

SCGB1A1

Scgb1a1

0.017

0.163

0.09

0.736

3.8E-2

1.2E-3

5.1E-2

1.8E-2

4.6E-6

  1. * The beta coefficient corresponds to the mean change in gene expression per day during the studied period.
  2. † Adjusted p-value (B-H method). ‡ Combined p-value for all data sets (human and murine) using the weighted z-score method.
  3. Empty boxes (-) indicate that the gene was not represented on the chip. Bolded rows indicate genes with at least one significant probe per gene in all tested data sets (adjusted p-value <0.05).
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Respiratory Research

ISSN: 1465-993X

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