Expression analysis of asthma candidate genes during human and murine lung development

Respiratory Research

Table 2 Proportion of the asthma gene probes among probes differentially expressed during lung development in human and mouse data sets

	Human lungs			Mouse A/J lungs			Mouse SW lungs			Mouse C57BL6 lungs
	Asthma probes			Asthma probes			Asthma probes			Asthma probes
Differentially expressed	Yes	No	Total*	Yes	No	Total*	Yes	No	Total*	Yes	No	Total*
Yes	71	11373	11444	25	3285	3310	15	2052	2067	32	6637	6669
No	149	29017	29166	64	8511	8575	71	9189	9260	110	32161	32271
Total	220	40390	40610	89	11796	11885	86	11241	11327	142	38798	38940
% differentially expressed probes	32	28	28	28	28	28	17	18	18	23	17	17
p-value†	0.18			1.0			1.0			0.09
OR (95% CI)	1.22 (0.90-1.63)			1.01 (0.61-1.63)			0.95 (0.50-1.67)			1.41 (0.92-2.11)

* Analyses restricted to probes represented by annotated genes.
† Fisher's exact test.
"Differentially expressed" refers to an adjusted p-value of <0.05 in the linear regression model.
OR = Odds ratio. CI = Confidence interval.

ISSN: 1465-993X