Table 4 TIMP1 SNPs and development of COPD in Vlagtwedde/Vlaardingen (GOLD stage ≥ II), stratified by sex.
FEMALES | MALES | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | No COPD N (%) | COPD N (%) | P value | Â | Â | No COPD N (%) | COPD N (%) | P value |
TIMP1 Ile158Ile | CC | 572 (98.5) | 43 (93.5) | 0.051 | TIMP1 Ile158Ile | C | 533 (98.9) | 130 (99.2) | 0.724 |
| Â | CT | 9 (1.5) | 3 (6.5) | Â | Â | T | 6 (1.1) | 1 (0.8) | Â |
| Â | TT | 0 (0) | 0 (0) | Â | Â | Â | Â | Â | Â |
TIMP1 Phe124Phe | TT | 122 (21.1) | 12 (25.0) | 0.298 | TIMP1 Phe124Phe | T | 264 (50.4) | 60 (45.8) | 0.348 |
| Â | TC | 308 (53.2) | 20 (41.7) | Â | Â | C | 260 (49.6) | 71 (54.2) | Â |
| Â | CC | 149 (25.7) | 16 (33.3) | Â | Â | Â | Â | Â | Â |