Figure 9From: Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesisIn vivomodulation of cholesterol in CF and wt mice with resveratrol. Membrane cholesterol measurement in Cftr -/- mouse (A) nasal epithelium and in Cftr +/+ mouse (B) nasal epithelium in response to in vivo exposure to resveratrol (drug treated, RES) (15-28 mg/kg body weight) for 3 to 6 weeks. Representative tracings of electrochemical detection of membrane cholesterol are shown. Shown are three separate tracings (separate electrodes) from tissue from a single mouse. C) Tissues from three treated and three untreated Cftr -/- mice were examined by eight separate electrodes and means represented in bar graph. Tissues from three treated and three untreated Cftr +/+ mice were examined by six separate electrodes and means represented in bar graph *Significance determined from n = 3, p-value < 0.05 as determined by t-test.Back to article page