Figure 6

Effect of LPS on airway constriction and PGE2 level in cPLA2α -/- mice. PGE2 levels were determined 24 h after LPS or saline instillation (A). Basal Penh levels in both cPLA2α -/- and cPLA2α +/+ mice were measured for 40 min. Then, LPS (330 μg/kg) or saline were instilled intranasally and Penh was monitored as described before. A representative graph is shown in B. The means of Penh values at the interval times between 200 to 300 min were presented in C. * p < 0.05 and †† p < 0.01, LPS vs saline-treated mice; ** p < 0.01 and † p < 0.05, LPS-treated cPLA2α +/+ vs cPLA2α -/- mice; ns, no significant differences between LPS vs saline-treated CFTR -/- mice.