Figure 5

Effect of ATK on airway constriction of CFTR-/- mice. Either ATK (20 mg/Kg) or its vehicle, ethanol, were administered intraperitoneally to CFTR-/- and CFTR +/+ mice and basal Penh levels were measured for 40 min. Then, LPS (330 μg/kg) or saline were instilled intranasally and Penh was monitored as described before. A representative graph is shown in A. The means of Penh values at the interval periods between 200 to 300 min were presented in B. * p < 0.05 ethanol-treated CFTR -/- vs CFTR +/+ mice; ** p < 0.01 ethanol vs ATK-treated LPS challenged CFTR +/+ mice; †† p < 0.01 ethanol vs ATK-treated LPS challenged CFTR -/- mice.