Table 6 Drugs potentially active on airway vascular remodelling
From: The role of the bronchial microvasculature in the airway remodelling in asthma and COPD
Name | Type of compound | Mode of Action |
|---|---|---|
Drugs active on VEGF Bevacizumab | Humanized IgG1 monoclonal antibody against VEGF | Neutralization of VEGF |
VEGF Trap | Engineered soluble receptor | Prevention of ligand binding |
Sorafenib, Sunitinib | Multitargeted receptor tyrosine kinase inhibitors | Inhibition of signal transduction and transcription |
Neovastat | Multifunctional agent obtained from dogfish cartilage | Interference with VEGFR2 Induction of EC apoptosis Inhibition of MMP activities |
Drugs active on FGF SU6668 | Competitive inhibitor of FGFR1, Flk-1/KDR, PDGFRβ via receptor tyrosine kinase | Inhibition of signal transduction and transcription |
Drugs active on TGFβ SR2F | Antagonist of the soluble receptor:Fc fusion protein class | Neutralization of TGFβ |
Drugs active on MMPs AZ11557272 | MMP-9/MMP-12 inhibitor | Inhibition of collagen and elastin destruction |