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Figure 3 | Respiratory Research

Figure 3

From: GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma

Figure 3

GITR stimulation in vivo induces enhanced Th2 cytokine production ex vivo. Effect of treatment with DTA-1 in vivo on T-lymphocyte cytokine production ex vivo. Lung lymphocytes derived from OVA challenged mice treated with DTA-1 (black bars) or control antibody (white bars) were cultured for 5 days in medium only (control), or in presence of plate-bound anti-CD3ε or soluble OVA (10 μg/ml). (A) IL-5 production, (B) IL-10 production, (C) IL-13 production and (D) IFNγ production in ng/ml. *: P < 0.05 and **:P < 0.01 as compared to control antibody treatment. The results shown are from one experiment out of two independent experiments performed (giving similar results).

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Respiratory Research

ISSN: 1465-993X

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