Table 2 Effect of Tiotropium treatment on levels of desmosine and Isodesmosine

-1-

0 month

1 month

2 month

6.57

4.99

5.29

49.6

48.5

38.5

0.42

0.37

0.47

0.92

0.15

0.05

-2-

0 month

1 month

2 month

9.50

5.91

7.50

40.8

41.9

32.7

0.71

0.67

0.45

0.77

0.19

0.33

-3-

0 month

1 month

2 month

3.90

5.37

4.45

35.1

38.1

39.9

0.71

0.54

0.33

0.52

0.26

0.10

-4-

0 month

1 month

2 month

5.14

4.82

6.91

45.0

42.3

32.5

0.77

0.40

0.45

0.33

0.23

0.18

-5-

0 month

1 month

2 month

7.54

4.95

4.68

46.2

51.4

47.1

0.73

0.57

0.55

0.49

0.16

0.14

-6-

0 month

1 month

2 month

3.31

3.72

3.05

36.2

34.2

31.4

0.44

0.40

0.50

0.05

0.01

0.03

-7-

0 month

1 month

2 month

3.40

5.38

4.79

40.9

40.2

37.4

0.62

0.63

0.61

0.23

0.30

0.22

-8-

0 month

1 month

2 month

3.76

3.48

3.15

39.4

35.3

35.0

0.52

0.39

0.42

0.27

0.29

0.13

-9-

0 month

1 month

2 month

6.61

5.26

4.71

63.2

43.0

39.1

0.51

0.64

0.46

0.19

0.22

0.10

-10-

0 month

1 month

2 month

7.59

5.98

4.87

50.7

46.6

43.9

0.75

0.46

0.26

0.19

0.12

0.06

-11-

0 month

1 month

2 month

5.67

4.71

4.97

51.0

45.3

40.2

0.61

0.38

0.33

0.22

0.08

0.08

-12-

0 month

1 month

2 month

5.83

5.13

5.55

53.4

48.9

39.7

0.67

0.34

0.33

0.52

1.07

0.13

Normal Subjects[5]

(n-13)

2.52 (± 0.53)

19.0

(± 2.0)

0.19

(= + 0,01)

none