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  1. Previous studies have shown that IL-25 levels are increased in patients with asthma with fixed airflow limitation (FAL). However, the mechanism by which IL-25 contributes to airway remodeling and FAL remains u...

    Authors: Xiujuan Yao, Qinglin Chen, Xiangdong Wang, Xiaofang Liu and Luo Zhang
    Citation: Respiratory Research 2023 24:212
  2. Pulmonary fibrosis is a progressive disease characterized by lung remodeling due to excessive deposition of extracellular matrix. Although the etiology remains unknown, aberrant angiogenesis and inflammation p...

    Authors: Laura Cucinotta, Deborah Mannino, Giovanna Casili, Alberto Repici, Lelio Crupi, Irene Paterniti, Emanuela Esposito and Michela Campolo
    Citation: Respiratory Research 2023 24:211
  3. Authors: Haruko Takeuchi, S. M. Tafsir Hasan, Khalequ Zaman, Sayaka Takanashi, Samar Kumar Hore, Sultana Yeasmin, Shaikh Meshbahuddin Ahmad, Md Jahangir Alam, Masamine Jimba, Tsutomu Iwata and Md Alfazal Khan
    Citation: Respiratory Research 2023 24:210

    The original article was published in Respiratory Research 2021 22:35

  4. Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterised by decline in lung function. We evaluated trajectories of forced vital capacity (FVC) and diffusing capaci...

    Authors: Megan L Neely, Anne S Hellkamp, Shaun Bender, Jamie L Todd, Timothy Liesching, Tracy R Luckhardt, Justin M Oldham, Rishi Raj, Eric S White and Scott M Palmer
    Citation: Respiratory Research 2023 24:209
  5. Non-invasive ventilation (NIV) is an evidence-based treatment for acute respiratory failure in chronic obstructive pulmonary disease (COPD). However, suboptimal application of NIV in clinical practice, possibl...

    Authors: Judith Elshof, Judith M. Vonk, Anouschka van der Pouw, Cella van Dijk, Petra Vos, Huib A.M. Kerstjens, Peter J. Wijkstra and Marieke L. Duiverman
    Citation: Respiratory Research 2023 24:208
  6. Acute exacerbations of chronic inflammatory lung diseases, such as chronic obstructive pulmonary disease (COPD), are frequently associated with rhinovirus (RV) infections. Despite these associations, the path...

    Authors: Ying Wang, Dennis K. Ninaber, Alen Faiz, Abraham C. van der Linden, Annemarie van Schadewijk, René Lutter, Pieter S. Hiemstra, Anne M. van der Does and Abilash Ravi
    Citation: Respiratory Research 2023 24:207
  7. Due to the high risk of COVID-19 patients developing thrombosis in the circulating blood, atherosclerosis, and myocardial infarction, it is necessary to study the lipidome of erythrocytes. Specifically, we exa...

    Authors: Alaa Khedr, Maan T. Khayat, Ahdab N. Khayyat, Hany Z. Asfour, Rahmah A. Alsilmi and Ahmed K. Kammoun
    Citation: Respiratory Research 2023 24:206
  8. Rhinovirus (RV) infection of airway epithelial cells triggers asthma exacerbations, during which airway smooth muscle (ASM) excessively contracts. Due to ASM contraction, airway epithelial cells become mechani...

    Authors: Alane Blythe C. Dy, Jason Girkin, Antonella Marrocco, Adam Collison, Chimwemwe Mwase, Michael J. O’Sullivan, Thien-Khoi N. Phung, Joerg Mattes, Cynthia Koziol-White, James E. Gern, Yury A. Bochkov, Nathan W. Bartlett and Jin-Ah Park
    Citation: Respiratory Research 2023 24:205
  9. Pulmonary hypertension (PH) is a lethal vascular disease with limited therapeutic options. The mechanistic connections between alveolar hypoxia and PH are not well understood. The aim of this study was to inve...

    Authors: Rongrong Chen, Hongfei Wang, Cuiting Zheng, Xiyu Zhang, Li Li, Shengwei Wang, Hongyu Chen, Jing Duan, Xian Zhou, Haiyong Peng, Jing Guo, Anchen Zhang, Feifei Li, Wang Wang, Yu Zhang, Jun Wang…
    Citation: Respiratory Research 2023 24:204
  10. A growing body of evidence suggests that use of race terms in spirometry reference equations underestimates disease burden in Black populations, which may lead to disparities in pulmonary disease outcomes. Dat...

    Authors: Allison J. Burbank, Claire E. Atkinson, Andre E. Espaillat, Stephen A. Schworer, Katherine Mills, Jennifer Rooney, Ceila E. Loughlin, Wanda Phipatanakul and Michelle L. Hernandez
    Citation: Respiratory Research 2023 24:203
  11. Right heart failure is the leading cause of death in pulmonary hypertension (PH), and echocardiography is a commonly used tool for evaluating the risk hierarchy of PH. However, few studies have explored the dy...

    Authors: Meidan Kuang, Yilin Chen, Yue Xing, Min Du, Huazhuo Feng, Qifeng Yang, Dongmei Wen, Xuanyi Li, Kai Yang, Ziying Lin, Ning Lai, Qian Jiang, Shiyun Liu, Dansha Zhou, Wei Hong, Xin Fu…
    Citation: Respiratory Research 2023 24:202
  12. Alveolar macrophages (AMs) and AM-produced matrix metalloprotease (MMP)-12 are known to play critical roles in the pathogenesis of chronic obstructive pulmonary disease (COPD). The apoptosis inhibitor of the m...

    Authors: Michiko Takimoto-Sato, Masaru Suzuki, Hiroki Kimura, Haiyan Ge, Munehiro Matsumoto, Hironi Makita, Satoko Arai, Toru Miyazaki, Masaharu Nishimura and Satoshi Konno
    Citation: Respiratory Research 2023 24:201
  13. Data from clinical trials of lumacaftor-ivacaftor (LUM-IVA) demonstrate improvements in lung clearance index (LCI) but not in FEV1 in children with Cystic Fibrosis (CF) aged 6–11 years and homozygous for the Phe5...

    Authors: Paul McNally, Barry Linnane, Michael Williamson, Basil Elnazir, Christopher Short, Clare Saunders, Laura Kirwan, Rea David, Mariette P. C. Kemner-Van de Corput, Harm A.W.M. Tiddens, Jane C Davies and Des W Cox
    Citation: Respiratory Research 2023 24:199
  14. The primary underlying defect in cystic fibrosis (CF) is disrupted ion transport in epithelia throughout the body. It is unclear if symptoms such as airway hyperreactivity (AHR) and increased airway smooth mus...

    Authors: Elizabeth L. Kramer, Kristin M. Hudock, Cynthia R. Davidson and John P. Clancy
    Citation: Respiratory Research 2023 24:198
  15. Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and ...

    Authors: Michael G. Katz, Yoav Hadas, Adam Vincek, Lina Freage-Kahn, Nataly Shtraizent, Jeko M. Madjarov, Peter Pastuszko and Efrat Eliyahu
    Citation: Respiratory Research 2023 24:197
  16. Coronavirus disease 2019 (COVID-19) patients can develop pulmonary fibrosis (PF), which is associated with impaired outcome. We assessed specific leukocytic transcriptome profiles associated with PF and the in...

    Authors: Emma J. Kooistra, Kilian Dahm, Antonius E. van Herwaarden, Jelle Gerretsen, Melanie Nuesch Germano, Karoline Mauer, Ruben L. Smeets, Sjef van der Velde, Maarten J. W. van den Berg, Johannes G. van der Hoeven, Anna C. Aschenbrenner, Joachim L. Schultze, Thomas Ulas, Matthijs Kox and Peter Pickkers
    Citation: Respiratory Research 2023 24:196
  17. Acute pulmonary embolism (APE) is a hazardous disorder with a high mortality. Combination of clinical, radiological, and serological parameters can improve risk stratification of APE. Most of the proposed comb...

    Authors: Alexey Surov, Maximilian Thormann, Caroline Bär, Andreas Wienke and Jan Borggrefe
    Citation: Respiratory Research 2023 24:195
  18. Oxidative stress and persistent airway inflammation are thought to be important contributors to the development of chronic obstructive pulmonary disease (COPD). This review summarizes the evidence for targetin...

    Authors: Mario Cazzola, Clive P. Page, Jadwiga A. Wedzicha, Bartolome R. Celli, Antonio Anzueto and Maria Gabriella Matera
    Citation: Respiratory Research 2023 24:194
  19. Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation. Bromodomain and extra-terminal...

    Authors: Sharon Mumby, Frederic Perros, Julien Grynblat, Gregoire Manaud, Alberto Papi, Paolo Casolari, Gaetano Caramori, Marc Humbert, S. John Wort and Ian M. Adcock
    Citation: Respiratory Research 2023 24:193
  20. Chronic lung allograft dysfunction (CLAD) directly causes an abysmal long-term prognosis after lung transplantation (LTx), but effective and safe drugs are not available. Metformin exhibits high therapeutic po...

    Authors: Dong Tian, Xiangyun Zheng, Hongtao Tang, Heng Huang, Junjie Wang, Lin Xu, Caihan Li, Haoji Yan, Ruixuan Yu, Jinzhu Nan, Menggen Liu, Xiaoguang Guo, Shunhai Jian, Tao Wang, Senyi Deng, Qiang Pu…
    Citation: Respiratory Research 2023 24:192
  21. Although different phenotypes of lung disease after preterm birth have recently been described, the underlying mechanisms associated with each phenotype are poorly understood. We, therefore, compared the urina...

    Authors: Christopher W Course, Philip A Lewis, Sarah J Kotecha, Michael Cousins, Kylie Hart, W John Watkins, Kate J Heesom and Sailesh Kotecha
    Citation: Respiratory Research 2023 24:191
  22. Observational studies have shown an association between higher bilirubin levels and improved respiratory health outcomes. Targeting higher bilirubin levels has been proposed as a novel therapeutic strategy in ...

    Authors: Arianne K. Baldomero, David M. MacDonald, Adam Kaplan, Eric Lock, Michael H. Cho, Russell Bowler, Lucas Gillenwater, Ken M. Kunisaki and Chris H. Wendt
    Citation: Respiratory Research 2023 24:190
  23. Accumulating clinical evidence links Obstructive Sleep Apnea (OSA) with worse outcomes of asthma, but impact on airway function remains sparsely studied. We tested effects of Chronic Intermittent Hypoxia (CIH)...

    Authors: Mihaela Teodorescu, Ruolin Song, Jacqueline A. Brinkman and Ronald L. Sorkness
    Citation: Respiratory Research 2023 24:189
  24. Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a product of the extracellular degradation of ad...

    Authors: Taha Kelestemur, Zoltán H. Németh, Pal Pacher, Jennet Beesley, Simon C. Robson, Holger K. Eltzschig and György Haskó
    Citation: Respiratory Research 2023 24:186
  25. Bacterial pneumonia and related lung injury are among the most frequent causes of mortality in intensive care units, but also inflict serious and prolonged respiratory complications among survivors. Given that...

    Authors: Eugene Becker Jr., Maroof Husain, Nathaniel Bone, Samuel Smith, Peter Morris and Jaroslaw W. Zmijewski
    Citation: Respiratory Research 2023 24:185
  26. Asthma exacerbations in children are associated with respiratory viral infection and atopy, resulting in systemic immune activation and infiltration of immune cells into the airways. The gene networks driving ...

    Authors: Anya C. Jones, Jonatan Leffler, Ingrid A. Laing, Joelene Bizzintino, Siew-Kim Khoo, Peter N. LeSouef, Peter D. Sly, Patrick G. Holt, Deborah H. Strickland and Anthony Bosco
    Citation: Respiratory Research 2023 24:184
  27. The oral cavity is the gateway to the bacteria community in the lung. Disruption of the symbiotic balance of the oral microbiota has been associated with respiratory diseases. However, little is known about th...

    Authors: Rajesh Shigdel, Ane Johannessen, Huang Lin, Shyamal Peddada, Francisco Gómez Real, Tamar Ringel-Kulka, Cecilie Svanes and Randi Jacobsen Bertelsen
    Citation: Respiratory Research 2023 24:183
  28. Alveolar epithelial barrier is a potential therapeutic target for acute respiratory distress syndrome (ARDS). However, an effective intervention against alveolar epithelial barrier has not been developed. Here...

    Authors: Dong Zhang, Jianning Zhang, Jintao Zhang, Xiang Ji, Qian Qi, Jiawei Xu, Yun Pan, Xiaofei Liu, Fang Sun, Rong Zeng and Liang Dong
    Citation: Respiratory Research 2023 24:182
  29. While asthma is considered an inflammatory-mediated airway epithelial and smooth muscle disorder, there is increasing evidence of airway capillary endothelial dysfunction associated with vascular remodelling a...

    Authors: Yael Strulovici-Barel, Robert J. Kaner and Ronald G. Crystal
    Citation: Respiratory Research 2023 24:180
  30. To address the limited utility of the interferon (IFN)-γ release assay (IGRA) caused by its variability and inconsistency.

    Authors: Yun Jung Jung, Ji Eun Park, Ji Won Park, Keu Sung Lee, Wou Young Chung, Joo Hun Park, Seung Soo Sheen, Seulgi You, Joo Sung Sun, Kyung Joo Park, Youn Jung Kim and Kwang Joo Park
    Citation: Respiratory Research 2023 24:179
  31. It has previously been shown that the Helicobacter pylori (H. pylori)-derived molecule vacuolating cytotoxin A (VacA) could be suitable for the treatment of allergic airway disease. The therapeutic activity of th...

    Authors: Jonas Raspe, Mona S. Schmitz, Kimberly Barbet, Georgia C. Caso, Timothy L. Cover, Anne Müller, Christian Taube and Sebastian Reuter
    Citation: Respiratory Research 2023 24:178
  32. Sepsis and associated organ failures confer substantial morbidity and mortality. Xanthine oxidoreductase (XOR) is implicated in the development of tissue oxidative damage in a wide variety of respiratory and c...

    Authors: Li Gao, Nicholas Rafaels, Tanda M. Dudenkov, Mahendra Damarla, Rachel Damico, James P. Maloney, Marc Moss, Greg S. Martin, Jonathan Sevransky, Carl Shanholtz, Dan L. Herr, Joe G.N. Garcia, Tamara Hernandez-Beeftink, Jesús Villar, Carlos Flores, Terri H. Beaty…
    Citation: Respiratory Research 2023 24:177
  33. Lung squamous cell carcinoma (LUSC) is a subtype of non-small cell carcinoma, accounting for about 30% of all lung cancers. Yet, the evaluation of prognostic outcome and therapy response of patients with LUSC ...

    Authors: Guangxian Mao, Dongyong Yang, Bin Liu, Yu Zhang, Sijia Ma, Shang Dai, Guoqiang Wang, Wenxiang Tang, Huafei Lu, Shangli Cai, Jialiang Zhu and Huaping Yang
    Citation: Respiratory Research 2023 24:176
  34. Early studies indicated that vitamin D (VD) exerted pleiotropic extra-skeletal effects in the airway, but the definite linkage between VD deficiency and airway host responses remains unclear.

    Authors: Shumin Liao, Yanhong Huang, Jinxiu Zhang, Qinglan Xiong, Mengshi Chi, Liang Yang, Junhang Zhang, Liang Li and Yunping Fan
    Citation: Respiratory Research 2023 24:175
  35. C-type natriuretic peptide (CNP) is an endothelium-derived paracrine molecule with an important role in vascular homeostasis. In septic patients, the serum level of the amino-terminal propeptide of CNP (NT-pro...

    Authors: Istvan Bojti, Anne-Sophie Przewosnik, Hendrik Luxenburger, Maike Hofmann, Christoph Neumann-Haefelin, Jennifer S. Esser, Patrick M. Siegel, Alexander Maier, Sarolta Bojtine Kovacs, Laszlo Kardos, Zoltan Csanádi, Marina Rieder, Daniel Duerschmied, Achim Lother, Christoph Bode, Gabor Tamas Szabó…
    Citation: Respiratory Research 2023 24:174
  36. Asthma is a common disease in childhood and adolescence with lifelong consequences particularly among those at risk of severe disease, poor control and/or frequent exacerbations. Specialist care is recommended...

    Authors: Kjell Erik Julius HÃ¥kansson, Silvia Cabrera Guerrero, Vibeke Backer, Charlotte Suppli Ulrik and Deepa Rastogi
    Citation: Respiratory Research 2023 24:173
  37. Patients with chronic obstructive pulmonary disease (COPD) have a high incidence of cardiovascular disease including thromboembolisms. Fibrin degradation products, like D-dimer, have been associated with death...

    Authors: Peter Kamstrup, Pradeesh Sivapalan, Christian Rønn, Ema Rastoder, Daniel Modin, Anna Kjaer Kristensen, Elisabeth Bendstrup, Rikke Sørensen, Tor Biering-Sørensen, Charlotte Suppli Ulrik, Jørgen Vestbo and Jens-Ulrik Jensen
    Citation: Respiratory Research 2023 24:172
  38. Obstructive sleep apnea (OSA) during pregnancy is a risk factor for preeclampsia possibly through a link to placental physiology. This study evaluates the efficacy of continuous positive airway pressure (CPAP)...

    Authors: Visasiri Tantrakul, Atiporn Ingsathit, Somprasong Liamsombut, Sasivimol Rattanasiri, Prapun Kittivoravitkul, Nutthaphon Imsom-Somboon, Siwaporn Lertpongpiroon, Surasak Jantarasaengaram, Werapath Somchit, Worakot Suwansathit, Janejira Pengjam, Sukanya Siriyotha, Panyu Panburana, Christian Guilleminault, Aroonwan Preutthipan, John Attia…
    Citation: Respiratory Research 2023 24:171
  39. Currently, there are no reliable clinical tools available to identify persistent asthma symptoms among preschool children with recurrent wheezing. We investigated iron homeostasis in the airways of preschooler...

    Authors: Zhili Wang, Yu He, Qinyuan Li, Yan Zhao, Guangli Zhang and Zhengxiu Luo
    Citation: Respiratory Research 2023 24:170
  40. The burden of asthma in terms of premature death or reduced quality of life remains a huge issue. It is of great importance to evaluate asthma burden geographically and time trends from 1990 to 2019 and to ass...

    Authors: Zhufeng Wang, Yun Li, Yi Gao, Yu Fu, Junfeng Lin, Xuedong Lei, Jinping Zheng and Mei Jiang
    Citation: Respiratory Research 2023 24:169
  41. The current nodal (pN) classification still has limitations in stratifying the prognosis of small cell lung cancer (SCLC) patients with pathological classifications T1-2N0-2M0. Thus. This study aimed to develo...

    Authors: Lei-Lei Wu, Li-Hong Qiu, Xiaolu Chen, Wan-Jun Yu, Chong-Wu Li, Jia-Yi Qian, Shen-Hua Liang, Peng Lin, Hao Long, Lan-Jun Zhang, Zhi-Xin Li, Kun Li, Feng Jiang, Guo-Wei Ma and Dong Xie
    Citation: Respiratory Research 2023 24:168
  42. The origin of αSMA-positive myofibroblasts, key players within organ fibrosis, is still not fully elucidated. Pericytes have been discussed as myofibroblast progenitors in several organs including the lung.

    Authors: Annemarie Aue, Nils Englert, Leon Harrer, Fabian Schwiering, Annika Gaab, Peter König, Ralf Adams, Achim Schmidtko, Andreas Friebe and Dieter Groneberg
    Citation: Respiratory Research 2023 24:167
  43. Matrix metalloproteinase-3 (MMP-3) is a proteolytic enzyme involved in acute respiratory distress syndrome (ARDS) pathophysiology that may serve as a lung-specific biomarker in ARDS.

    Authors: Timothy W. Jones, Sultan Almuntashiri, Aaron Chase, Abdullah Alhumaid, Payaningal R. Somanath, Andrea Sikora and Duo Zhang
    Citation: Respiratory Research 2023 24:166
  44. Pulmonary arterial hypertension (PAH) is a rare but fatal cardiopulmonary disease mainly characterized by pulmonary vascular remodeling. Aberrant expression of circRNAs has been reported to play a crucial role...

    Authors: Hua Su, Huiqi Zhu, Sihao Wang, Yeping Li, Chao Yan, Jiaoyan Wang and Kejing Ying
    Citation: Respiratory Research 2023 24:165
  45. The introduction of the novel therapy, Elexacaftor/Tezacaftor/Ivacaftor (ETI) has been effective in improving weight gain in both clinical trials and real-world studies. However, the magnitude of this effect a...

    Authors: Andrea Gramegna, Fabio Majo, Gianfranco Alicandro, Gloria Leonardi, Luca Cristiani, Francesco Amati, Martina Contarini, Stefano Aliberti, Alessandro Giovanni Fiocchi and Francesco Blasi
    Citation: Respiratory Research 2023 24:164
  46. Pre-operative and post-operative hypoxemia are frequent complications of Stanford type A aortic dissection (AAD). This study explored the effect of pre-operative hypoxemia on the occurrence and outcome of post...

    Authors: Teng Cai, Zhonghua Fei, Hongsheng Liu, Xinmei Liu and Zhansheng Hu
    Citation: Respiratory Research 2023 24:161

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