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  1. Content type: Research

    COPD is a heterogeneous chronic inflammatory disease of the airways and it is well accepted that the GOLD classification does not fully represent the complex clinical manifestations of COPD and this classifica...

    Authors: Adèle Lo Tam Loi, Susan Hoonhorst, Corneli van Aalst, Jeroen Langereis, Vera Kamp, Simone Sluis-Eising, Nick ten Hacken, Jan-Willem Lammers and Leo Koenderman

    Citation: Respiratory Research 2017 18:100

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  2. Content type: Research

    Skeletal muscle weakness in chronic obstructive pulmonary disease (COPD) is an important predictor of poor prognosis, but the molecular mechanisms of muscle weakness in COPD have not been fully elucidated. The...

    Authors: Masako To, Elisabeth B. Swallow, Kenich Akashi, Kosuke Haruki, S Amanda Natanek, Michael I. Polkey, Kazuhiro Ito and Peter J. Barnes

    Citation: Respiratory Research 2017 18:99

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  3. Content type: Research

    We conducted a genome-wide association study (GWAS) of subclinical interstitial lung disease (ILD), defined as high attenuation areas (HAA) on CT, in the population-based Multi-Ethnic Study of Atherosclerosis ...

    Authors: Ani Manichaikul, Xin-Qun Wang, Li Sun, Josée Dupuis, Alain C. Borczuk, Jennifer N. Nguyen, Ganesh Raghu, Eric A. Hoffman, Suna Onengut-Gumuscu, Emily A. Farber, Joel D. Kaufman, Dan Rabinowitz, Karen D. Hinckley Stukovsky, Steven M. Kawut, Gary M. Hunninghake, George R. Washko…

    Citation: Respiratory Research 2017 18:97

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  4. Content type: Review

    Monitoring of pulmonary physiology is fundamental to the clinical management of patients with Cystic Fibrosis. The current standard clinical practise uses spirometry to assess lung function which delivers a cl...

    Authors: Magdalena Kołodziej, Michael J. de Veer, Marian Cholewa, Gary F. Egan and Bruce R. Thompson

    Citation: Respiratory Research 2017 18:96

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  5. Content type: Research

    The Australian Synchrotron Imaging and Medical Beamline (IMBL) was designed as the world’s widest synchrotron X-ray beam, enabling both clinical imaging and therapeutic applications for humans as well as the i...

    Authors: Martin Donnelley, Kaye S. Morgan, Maged Awadalla, Nigel R. Farrow, Chris Hall and David W. Parsons

    Citation: Respiratory Research 2017 18:95

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  6. Content type: Research

    Thickening of reticular basement membrane, increased airway smooth muscle mass and eosinophilic inflammation are found in adult fatal asthma. At the present study the histopathology of fatal paediatric and ado...

    Authors: Kristiina Malmström, Jouko Lohi, Antti Sajantila, Frode L. Jahnsen, Merja Kajosaari, Seppo Sarna and Mika J. Mäkelä

    Citation: Respiratory Research 2017 18:94

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  7. Content type: Research

    Cigarette smoke exposure is the major risk factor for developing COPD. Presently, available COPD treatments focus on suppressing inflammation and providing bronchodilation. However, these options have varying ...

    Authors: Mark Bazett, Agnieszka Biala, Ryan D. Huff, Matthew R. Zeglinksi, Philip M. Hansbro, Momir Bosiljcic, Hal Gunn, Shirin Kalyan and Jeremy A. Hirota

    Citation: Respiratory Research 2017 18:92

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  8. Content type: Research

    The rising incidence of pulmonary Mycobacterium avium-intracellulare complex (MAI) infection is unexplained but parallels the growing world-wide epidemic of allergic disease. We hypothesized an association betwee...

    Authors: Paul E. Pfeffer, Susan Hopkins, Ian Cropley, David M. Lowe and Marc Lipman

    Citation: Respiratory Research 2017 18:93

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  9. Content type: Research

    Exposure to crystalline silica is considered to increase the risk of lung fibrosis. The primary effector cell, the myofibroblast, plays an important role in the deposition of extracellular matrix (ECM). DNA me...

    Authors: Juan Li, Wu Yao, Lin Zhang, Lei Bao, Huiting Chen, Di Wang, Zhongzheng Yue, Yiping Li, Miao Zhang and Changfu Hao

    Citation: Respiratory Research 2017 18:91

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  10. Content type: Research

    Increased lung macrophage numbers in COPD may arise from upregulation of blood monocyte recruitment into the lungs. CCR5 is a monocyte chemokine receptor regulated by interleukin-6 (IL-6); the concentration of...

    Authors: Arjun K Ravi, Jonathan Plumb, Rosemary Gaskell, Sarah Mason, Caroline S Broome, George Booth, Matthew Catley, Jørgen Vestbo and Dave Singh

    Citation: Respiratory Research 2017 18:90

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  11. Content type: Research

    In the early stages of acute respiratory distress syndrome (ARDS), pro-inflammatory mediators inhibit natural anticoagulant factors and initiate an increase in procoagulant activity. Previous studies proved th...

    Authors: Marta Camprubí–Rimblas, Raquel Guillamat-Prats, Thomas Lebouvier, Josep Bringué, Laura Chimenti, Manuela Iglesias, Carme Obiols, Jessica Tijero, Lluís Blanch and Antonio Artigas

    Citation: Respiratory Research 2017 18:89

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  12. Content type: Research

    The pulmonary neuroepithelial body (NEB) microenvironment (ME) consists of innervated cell clusters that occur sparsely distributed in the airway epithelium, an organization that has so far hampered reliable s...

    Authors: Line Verckist, Robrecht Lembrechts, Sofie Thys, Isabel Pintelon, Jean-Pierre Timmermans, Inge Brouns and Dirk Adriaensen

    Citation: Respiratory Research 2017 18:87

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  13. Content type: Research

    Sputum and blood eosinophil counts predict corticosteroid effects in COPD patients. Bacterial infection causes increased airway neutrophilic inflammation. The relationship of eosinophil counts with airway bact...

    Authors: Umme Kolsum, Gavin C. Donaldson, Richa Singh, Bethan L. Barker, Vandana Gupta, Leena George, Adam J. Webb, Sarah Thurston, Anthony J Brookes, Timothy D. McHugh, Jadwiga A. Wedzicha, Christopher E. Brightling and Dave Singh

    Citation: Respiratory Research 2017 18:88

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  14. Content type: Research

    Reducing rescue medication use is a guideline-defined goal of asthma treatment, however, little is known about the validity of rescue medicine use as a marker of symptoms in chronic obstructive pulmonary disea...

    Authors: Yogesh Suresh Punekar, Sheetal Sharma, Ankit Pahwa, Jitender Takyar, Ian Naya and Paul W. Jones

    Citation: Respiratory Research 2017 18:86

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  15. Content type: Research

    Pulmonary hypertension (PH) associated with lung disease has the worst prognosis of all types of PH. Pulmonary arterial vasculopathy is an early event in the natural history of chronic obstructive pulmonary di...

    Authors: Enric Domingo, Juan C. Grignola, Rio Aguilar, Manuel López Messeguer and Antonio Roman

    Citation: Respiratory Research 2017 18:85

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  16. Content type: Research

    The Rhinovirus C (RV-C), first identified in 2006, produce high symptom burdens in children and asthmatics, however, their primary target host cell in the airways remains unknown. Our primary hypotheses were t...

    Authors: Theodor F. Griggs, Yury A. Bochkov, Sarmila Basnet, Thomas R. Pasic, Rebecca A. Brockman-Schneider, Ann C. Palmenberg and James E. Gern

    Citation: Respiratory Research 2017 18:84

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  17. Content type: Research

    Smoking and aberrant epithelial responses are risk factors for lung cancer as well as chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. In these conditions, disease progression is associ...

    Authors: Lynne A. Murray, Rebecca Dunmore, Ana Camelo, Carla A. Da Silva, Malin J. Gustavsson, David M. Habiel, Tillie L Hackett, Cory M. Hogaboam, Matthew A. Sleeman and Darryl A. Knight

    Citation: Respiratory Research 2017 18:82

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  18. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is associated with several extra-pulmonary effects of which skeletal muscle wasting is one of the most common and contributes to reduced quality of life, increased ...

    Authors: Ramzi Lakhdar, Ellen M. Drost, William MacNee, Ricardo Bastos and Roberto A. Rabinovich

    Citation: Respiratory Research 2017 18:81

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  19. Content type: Research

    Although high-intensity non-invasive ventilation has been shown to improve outcomes in stable COPD, it may adversely affect cardiac performance. Therefore, the aims of the present pilot study were to compare c...

    Authors: Marieke Leontine Duiverman, Petra Maagh, Friederike Sophie Magnet, Claudia Schmoor, Maria Paola Arellano-Maric, Axel Meissner, Jan Hendrik Storre, Peter Jan Wijkstra, Wolfram Windisch and Jens Callegari

    Citation: Respiratory Research 2017 18:76

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  20. Content type: Research

    Exacerbations in COPD are often accompanied by pulmonary and systemic inflammation, and associated with increased susceptibility to and prevalence of weight loss and muscle wasting. Muscle mass loss during dis...

    Authors: Judith J. M. Ceelen, Annemie M. W. J. Schols, Stefan J. van Hoof, Chiel C. de Theije, Frank Verhaegen and Ramon C. J. Langen

    Citation: Respiratory Research 2017 18:75

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  21. Content type: Research

    Malignant pleural mesothelioma (MPM) is a difficult-to-treat global disease. Pegylated arginase (BCT-100) has recently shown anti-tumor effects in hepatocellular carcinoma, acute myeloid leukemia and melanoma....

    Authors: Sze-Kwan Lam, Yuan-Yuan Li, Shi Xu, Leanne Lee Leung, Kin-Pong U, Yan-Fang Zheng, Paul Ning-Man Cheng and James Chung-Man Ho

    Citation: Respiratory Research 2017 18:80

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  22. Content type: Research

    Identification of biomarkers of cigarette smoke –induced lung damage and early COPD is an area of intense interest. Glucose regulated protein of 78 kD (i.e., GRP78), a multi-functional protein which mediates c...

    Authors: Mark O. Aksoy, Victor Kim, William D. Cornwell, Thomas J. Rogers, Beata Kosmider, Karim Bahmed, Carlos Barrero, Salim Merali, Neena Shetty and Steven G. Kelsen

    Citation: Respiratory Research 2017 18:78

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  23. Content type: Research

    Epithelial-mesenchymal transition is currently recognized as an important mechanism for the increased number of myofibroblasts in cancer and fibrotic diseases. We have already reported that epithelial-mesenchy...

    Authors: Keigo Kainuma, Tetsu Kobayashi, Corina N. D’Alessandro-Gabazza, Masaaki Toda, Taro Yasuma, Kota Nishihama, Hajime Fujimoto, Yu Kuwabara, Koa Hosoki, Mizuho Nagao, Takao Fujisawa and Esteban C. Gabazza

    Citation: Respiratory Research 2017 18:79

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