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  1. Preclinical studies suggest that interleukin-9 may be a central mediator in the development and maintenance of airway inflammation in asthma. The aim of this study was therefore to evaluate the effects of MEDI...

    Authors: Chad K Oh, Richard Leigh, Kimmie K McLaurin, Keunpyo Kim, Micki Hultquist and Nestor A Molfino
    Citation: Respiratory Research 2013 14:93
  2. Mechanical ventilation (MV) may cause ventilator-induced lung injury (VILI) and may thereby contribute to fatal multiple organ failure. We tested the hypothesis that injurious MV of lipopolysaccharide (LPS) pr...

    Authors: Lonneke Smeding, Jan Willem Kuiper, Frans B Plötz, Martin CJ Kneyber and AB Johan Groeneveld
    Citation: Respiratory Research 2013 14:92
  3. Klebsiella pneumoniae is a leading cause of severe hospital-acquired respiratory tract infections and death but little is known regarding the modulation of respiratory dendritic cell (DC) subsets. Plasmacytoid...

    Authors: Holger Hackstein, Sabine Kranz, Anne Lippitsch, Andreas Wachtendorf, Olivia Kershaw, Achim D Gruber, Gabriela Michel, Jürgen Lohmeyer, Gregor Bein, Nelli Baal and Susanne Herold
    Citation: Respiratory Research 2013 14:91
  4. In fibrotic lung diseases, expression of caveolin-1 is decreased in fibroblasts and monocytes. The effects of this deficiency are reversed by treating cells or animals with the caveolin-1 scaffolding domain pe...

    Authors: Charles Reese, Shanice Dyer, Beth Perry, Michael Bonner, James Oates, Ann Hofbauer, William Sessa, Pascal Bernatchez, Richard P Visconti, Jing Zhang, Corey M Hatfield, Richard M Silver, Stanley Hoffman and Elena Tourkina
    Citation: Respiratory Research 2013 14:90
  5. Dopamine signaling is mediated by Gs protein-coupled “D1-like” receptors (D1 and D5) and Gi-coupled “D2-like” receptors (D2-4). In asthmatic patients, inhaled dopamine induces bronchodilation. Although the Gi-cou...

    Authors: Kentaro Mizuta, Yi Zhang, Dingbang Xu, Fumiko Mizuta, Frank D’Ovidio, Eiji Masaki and Charles W Emala
    Citation: Respiratory Research 2013 14:89
  6. Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoking is the leading risk factor for the development of COPD and 25% of asthmatics smoke. S...

    Authors: Magdalena H Hudy and David Proud
    Citation: Respiratory Research 2013 14:88
  7. High-dose steroid therapy has been proven effective in AIDS-related Pneumocystis pneumonia (PCP) but not in non-AIDS-related cases. We evaluated the effects on survival of steroids in HIV-negative patients wit...

    Authors: Virginie Lemiale, Alexandre Debrumetz, Alexandra Delannoy, Corinne Alberti and Elie Azoulay
    Citation: Respiratory Research 2013 14:87
  8. The carcinoembryonic antigen (CEA)-related cell adhesion molecules CEACAM1 (BGP, CD66a), CEACAM5 (CEA, CD66e) and CEACAM6 (NCA, CD66c) are expressed in human lung. They play a role in innate and adaptive immun...

    Authors: Esther Klaile, Tilman E Klassert, Inka Scheffrahn, Mario M Müller, Annina Heinrich, Kerstin A Heyl, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B Singer and Hortense Slevogt
    Citation: Respiratory Research 2013 14:85
  9. Chronic obstructive pulmonary disease (COPD) is characterized by structural changes in alveoli and airways. Our aim was to analyse the numbers of alpha-smooth muscle actin (α-SMA) positive cells, as a marker o...

    Authors: Henna M Karvonen, Siri T Lehtonen, Terttu Harju, Raija T Sormunen, Elisa Lappi-Blanco, Johanna M Mäkinen, Kirsi Laitakari, Shirley Johnson and Riitta L Kaarteenaho
    Citation: Respiratory Research 2013 14:84
  10. Lung growth in utero and lung function loss during adulthood can be affected by exposure to environmental tobacco smoke (ETS). The underlying mechanisms have not been fully elucidated. Both ETS exposure and singl...

    Authors: Kim de Jong, H Marike Boezen, Nick HT ten Hacken, Dirkje S Postma and Judith M Vonk
    Citation: Respiratory Research 2013 14:83
  11. Interstitial lung disease is a major cause of morbidity and mortality in systemic sclerosis (SSc), with insufficiently effective treatment options. Progression of pulmonary fibrosis involves expanding populati...

    Authors: Gisela E Lindahl, Carmel JW Stock, Xu Shi-Wen, Patricia Leoni, Piersante Sestini, Sarah L Howat, George Bou-Gharios, Andrew G Nicholson, Christopher P Denton, Jan C Grutters, Toby M Maher, Athol U Wells, David J Abraham and Elisabetta A Renzoni
    Citation: Respiratory Research 2013 14:80
  12. Patients with chronic obstructive pulmonary disease (COPD) can be categorized as having frequent (FE) or infrequent (IE) exacerbations depending on whether they respectively experience two or more, or one or z...

    Authors: Gavin C Donaldson, Hanna Müllerova, Nicholas Locantore, John R Hurst, Peter MA Calverley, Jorgen Vestbo, Antonio Anzueto and Jadwiga A Wedzicha
    Citation: Respiratory Research 2013 14:79
  13. Aspergillus fumigatus conidia can exacerbate asthma symptoms. Phagocytosis of conidia is a principal component of the host antifungal defense. We investigated whether allergic airway inflammation (AAI) affects th...

    Authors: Marina A Shevchenko, Elena L Bolkhovitina, Ekaterina A Servuli and Alexander M Sapozhnikov
    Citation: Respiratory Research 2013 14:78
  14. Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT4R) gene (HTR4) associated with lung function. The a...

    Authors: Emily Hodge, Carl P Nelson, Suzanne Miller, Charlotte K Billington, Ceri E Stewart, Caroline Swan, Anders Malarstig, Amanda P Henry, Catherine Gowland, Erik Melén, Ian P Hall and Ian Sayers
    Citation: Respiratory Research 2013 14:77
  15. The International Study on Asthma and Allergies in Childhood (ISAAC) reported a prevalence of asthma symptoms in 17 centers in nine Latin American countries that was similar to prevalence rates reported in non...

    Authors: Stèphan Kraai, Lilly M Verhagen, Enrique Valladares, Joaquin Goecke, Lorena Rasquin, Paula Colmenares, Berenice Del Nogal, Peter WM Hermans and Jacobus H de Waard
    Citation: Respiratory Research 2013 14:76
  16. Patients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce the...

    Authors: Laurent Bertoletti, Sara Quenet, Silvy Laporte, Joan Carles Sahuquillo, Francisco Conget, José María Pedrajas, Mar Martin, Ignacio Casado, Antonio Riera-Mestre and Manuel Monreal
    Citation: Respiratory Research 2013 14:75
  17. Acute exacerbation of idiopathic pulmonary fibrosis has become an important outcome measure in clinical trials. This study aimed to explore the concept of suspected acute exacerbation as an outcome measure.

    Authors: Harold R Collard, Eric Yow, Luca Richeldi, Kevin J Anstrom and Craig Glazer
    Citation: Respiratory Research 2013 14:73
  18. COPD exacerbations are associated with neutrophilic airway inflammation. Adhesion molecules on the surface of neutrophils may play a key role in their movement from blood to the airways. We analysed adhesion m...

    Authors: Patrick Mallia, Simon D Message, Marco Contoli, Katrina K Gray, Aurica Telcian, Vasile Laza-Stanca, Alberto Papi, Luminita A Stanciu, Sarah Elkin, Onn M Kon, Malcolm Johnson and Sebastian L Johnston
    Citation: Respiratory Research 2013 14:72
  19. Ciliated cells play a central role in cleansing the airways of inhaled contaminants. They are derived from basal cells that include the airway stem/progenitor cells. In animal models, the transcription factor ...

    Authors: Lukas Didon, Rachel K Zwick, Ion Wa Chao, Matthew S Walters, Rui Wang, Neil R Hackett and Ronald G Crystal
    Citation: Respiratory Research 2013 14:70
  20. Epithelial-mesenchymal transition (EMT) plays a crucial role in small airway fibrosis of patients with chronic obstructive pulmonary disease (COPD). Increasing evidence suggests that the urokinase plasminogen ...

    Authors: Qin Wang, Yunshan Wang, Yi Zhang, Yuke Zhang and Wei Xiao
    Citation: Respiratory Research 2013 14:67
  21. Exercise limitation is an important issue in patients with chronic obstructive pulmonary disease (COPD), and it often co-exists with obstructive sleep apnoea (overlap syndrome). This study examined the effects...

    Authors: Tsai-Yu Wang, Yu-Lun Lo, Kang-Yun Lee, Wen-Te Liu, Shu-Min Lin, Ting-Yu Lin, Yung-Lun Ni, Chao-Yung Wang, Shu-Chuan Ho and Han-Pin Kuo
    Citation: Respiratory Research 2013 14:66
  22. De novo lymphatic vessel formation has recently been observed in lungs of patients with moderate chronic obstructive pulmonary disease (COPD). However, the distribution of lymphatic vessel changes among the anato...

    Authors: Michiko Mori, Cecilia K Andersson, Gerard J Graham, Claes-Göran Löfdahl and Jonas S Erjefält
    Citation: Respiratory Research 2013 14:65
  23. We investigated the efficacy and safety of AZD3199, a novel inhaled ultra-LABA, with the main aim of establishing a dose that would maintain 24-hour bronchodilation in patients with COPD.

    Authors: Piotr Kuna, Yavor Ivanov, Vasily Ivanovich Trofimov, Takefumi Saito, Ola Beckman, Thomas Bengtsson, Carin Jorup and François Maltais
    Citation: Respiratory Research 2013 14:64
  24. Pro-inflammatory/cytotoxic T cells (IFNγ, TNFα, granzyme B+) are increased in the peripheral circulation in COPD. NKT-like and NK cells are effector lymphocytes that we have also shown to be major sources of p...

    Authors: Greg Hodge, Mark Holmes, Hubertus Jersmann, Paul N Reynolds and Sandra Hodge
    Citation: Respiratory Research 2013 14:63
  25. Long-acting beta-agonists were one of the first-choice bronchodilator agents for stable chronic obstructive pulmonary disease. But the impact of long-acting beta-agonists on mortality was not well investigated.

    Authors: Nobuyuki Horita, Naoki Miyazawa, Satoshi Morita, Ryota Kojima, Naoko Kimura, Takeshi Kaneko and Yoshiaki Ishigatsubo
    Citation: Respiratory Research 2013 14:62
  26. It has been debated whether treatment should be started early in subjects with mild to moderate COPD. An impaired health status score was associated with a higher probability of being diagnosed with COPD as co...

    Authors: Koichi Nishimura, Satoshi Mitsuma, Atsuko Kobayashi, Mikako Yanagida, Kazuhito Nakayasu, Yoshinori Hasegawa and Paul W Jones
    Citation: Respiratory Research 2013 14:61
  27. Although a large body of literature is available that describes the effects of smoking, asthma and COPD on lung function, most studies are restricted to a small age range and to one factor. As a consequence, a...

    Authors: Silvia Chiappa, John Winn, Ana Viñuela, Hannah Tipney and Timothy David Spector
    Citation: Respiratory Research 2013 14:60
  28. Beyond lung cancer, screening CT contains additional information on other smoking related diseases (e.g. chronic obstructive pulmonary disease, COPD). Since pulmonary function testing is not regularly incorpor...

    Authors: Onno M Mets, Michael Schmidt, Constantinus F Buckens, Martijn J Gondrie, Ivana Isgum, Matthijs Oudkerk, Rozemarijn Vliegenthart, Harry J de Koning, Carlijn M van der Aalst, Mathias Prokop, Jan-Willem J Lammers, Pieter Zanen, Firdaus A Mohamed Hoesein, Willem PThM Mali, Bram van Ginneken, Eva M van Rikxoort…
    Citation: Respiratory Research 2013 14:59
  29. The modified version of the Pulmonary Functional Status and Dyspnea Questionnaire (PFSDQ-M) is used in patients with COPD to obtain information about their functional status. It consists of 3 components (chang...

    Authors: Eloisa MG Regueiro, Chris Burtin, Paul Baten, Daniel Langer, Hans Van Remoortel, Valéria A Pires Di Lorenzo, Dirceu Costa, Wim Janssens, Marc Decramer, Rik Gosselink and Thierry Troosters
    Citation: Respiratory Research 2013 14:58
  30. Recent research has suggested that the Th1 and Th2 chemokine/cytokine axis contributes to the development of chronic hypersensitivity pneumonitis (HP). Acute exacerbations (AE) are significant factors in the p...

    Authors: Yasunari Miyazaki, Koji Unoura, Tomoya Tateishi, Takumi Akashi, Tamiko Takemura, Makoto Tomita, Naohiko Inase and Yasuyuki Yoshizawa
    Citation: Respiratory Research 2013 14:57
  31. Recent evidence has demonstrated the role of angiogenesis in the pathogenesis of pulmonary fibrosis. Endostatin, a proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis. The aim of our ...

    Authors: Yun-Yan Wan, Guang-Yan Tian, Hai-Sheng Guo, Yan-Meng Kang, Zhou-Hong Yao, Xi-Li Li, Qing-Hua Liu and Dian-Jie Lin
    Citation: Respiratory Research 2013 14:56
  32. Little is known about the factors associated with CT-quantified emphysema progression in heavy smokers. The objective of this study was to investigate the effect of length of smoking cessation and clinical / d...

    Authors: Firdaus AA Mohamed Hoesein, Pieter Zanen, Pim A de Jong, Bram van Ginneken, H Marike Boezen, Harry JM Groen, Mathijs Oudkerk, Harry J de Koning, Dirkje S Postma and Jan-Willem J Lammers
    Citation: Respiratory Research 2013 14:55
  33. GSK2190915 is a high affinity 5-lipoxygenase-activating protein inhibitor being developed for the treatment of asthma. The objective of this study was to evaluate GSK2190915 efficacy, dose–response and safety ...

    Authors: Richard MA Follows, Neil G Snowise, Shu-Yen Ho, Claire L Ambery, Kevin Smart and Barbara A McQuade
    Citation: Respiratory Research 2013 14:54
  34. Levels of Interleukin-6 (IL-6) and C-creative protein (CRP) indicating systemic inflammation are known to be elevated in chronic diseases including chronic obstructive pulmonary disease (COPD) and depression. ...

    Authors: Yanxia Lu, Lei Feng, Liang Feng, Ma Shwe Nyunt, Keng Bee Yap and Tze Pin Ng
    Citation: Respiratory Research 2013 14:53
  35. Mechanical ventilation can promote lung injury by triggering a pro-inflammatory response. Macrolides may exert some immunomodulatory effects and have shown significant benefits over other antibiotics in ventil...

    Authors: Laura Amado-Rodríguez, Adrián González-López, Inés López-Alonso, Alina Aguirre, Aurora Astudillo, Estefanía Batalla-Solís, Jorge Blazquez-Prieto, Emilio García-Prieto and Guillermo M Albaiceta
    Citation: Respiratory Research 2013 14:52
  36. Exposure to organic dust causes detrimental airway inflammation. Current preventative and therapeutic measures do not adequately treat resulting disease, necessitating novel therapeutic interventions. Recently...

    Authors: Tara M Nordgren, Art J Heires, Todd A Wyatt, Jill A Poole, Tricia D LeVan, D Roselyn Cerutis and Debra J Romberger
    Citation: Respiratory Research 2013 14:51
  37. With the recent widespread use of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), there have been occasional reports on complications associated with its use. Previous reviews on ...

    Authors: Fumihiro Asano, Motoi Aoe, Yoshinobu Ohsaki, Yoshinori Okada, Shinji Sasada, Shigeki Sato, Eiichi Suzuki, Hiroshi Semba, Kazuya Fukuoka, Shozo Fujino and Kazumitsu Ohmori
    Citation: Respiratory Research 2013 14:50
  38. The fractional exhaled nitric oxide (FeNO) is a quantitative, noninvasive and safe measure of airways inflammation that may complement the assessment of asthma. Elevations of FeNO have recently been found to c...

    Authors: Karina M Romero, Colin L Robinson, Lauren M Baumann, Robert H Gilman, Robert G Hamilton, Nadia N Hansel and William Checkley
    Citation: Respiratory Research 2013 14:48
  39. The aim of the study was to investigate how the expression of adhesion molecules changes as neutrophils migrate from the circulation to the lung and if these changes differ between non-smoking subjects and smo...

    Authors: Kristin Blidberg, Lena Palmberg, Anna James, Bo Billing, Elisabeth Henriksson, Ann-Sofie Lantz, Kjell Larsson and Barbro Dahlén
    Citation: Respiratory Research 2013 14:47
  40. Adult patients with cystic fibrosis have peripheral muscle weakness, which is related to exercise intolerance and poor prognosis. The influence of acute exacerbations on muscle strength has been poorly studied...

    Authors: Chris Burtin, Hans Van Remoortel, Bart Vrijsen, Daniel Langer, Kristine Colpaert, Rik Gosselink, Marc Decramer, Lieven Dupont and Thierry Troosters
    Citation: Respiratory Research 2013 14:46
  41. Cigarette smoking (CS) is the most important risk factor for COPD, which is associated with neutrophilic airway inflammation. We hypothesize, that highly reactive aldehydes are critical for CS-induced neutroph...

    Authors: Marco van der Toorn, Dirk-Jan Slebos, Harold G de Bruin, Renee Gras, Delaram Rezayat, Lucie Jorge, Koen Sandra and Antoon JM van Oosterhout
    Citation: Respiratory Research 2013 14:45

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