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  1. Ventilator-induced lung injury (VILI) is characterized by increased alveolar permeability, pulmonary edema. The tyrosine kinase, c-Src, is involved in VILI but its role has not been fully elucidated. This stud...

    Authors: Tao Zhao, Mengjie Liu, Changping Gu, Xin Wang and Yuelan Wang
    Citation: Respiratory Research 2014 15:158
  2. Although usual interstitial pneumonia (UIP) appears to portend better survival when associated with connective tissue disease (CTD-UIP), little is known about the presenting clinical, radiologic, and pathologi...

    Authors: Teng Moua, Ana C Zamora Martinez, Misbah Baqir, Robert Vassallo, Andrew H Limper and Jay H Ryu
    Citation: Respiratory Research 2014 15:154
  3. Atopic march refers to the typical transition from a food allergy in early childhood to allergic asthma in older children and adults. However the precise interplay of events involving gut, skin and pulmonary i...

    Authors: Tiphaine Bihouée, Gregory Bouchaud, Julie Chesné, David Lair, Camille Rolland-Debord, Faouzi Braza, Marie-Aude Cheminant, Philippe Aubert, Guillaume Mahay, Christine Sagan, Michel Neunlist, Sophie Brouard, Marie Bodinier and Antoine Magnan
    Citation: Respiratory Research 2014 15:142
  4. Adolescence is a period of change, which coincides with disease remission in a significant proportion of subjects with childhood asthma. There is incomplete understanding of the changing characteristics underl...

    Authors: Syed Hasan Arshad, Abid Raza, Laurie Lau, Khalid Bawakid, Wilfried Karmaus, Hongmei Zhang, Susan Ewart, Veersh Patil, Graham Roberts and Ramesh Kurukulaaratchy
    Citation: Respiratory Research 2014 15:153
  5. Surfactant protein D (SP-D) can regulate both innate and adaptive immunity. Recently, SP-D has been shown to contribute to the pathogenesis of airway allergic inflammation and bleomycin-induced pulmonary fibro...

    Authors: Hirohisa Ogawa, Julie G Ledford, Sambuddho Mukherjee, Yoshinori Aono, Yasuhiko Nishioka, James J Lee, Keisuke Izumi and John W Hollingsworth
    Citation: Respiratory Research 2014 15:143
  6. Several classifications of adult asthma patients using cluster analyses based on clinical and demographic information has resulted in clinical phenotypic clusters that do not address molecular mechanisms. Vola...

    Authors: Norbert Meyer, Jan W Dallinga, Sarah Janine Nuss, Edwin JC Moonen, Joep JBN van Berkel, Cezmi Akdis, Frederik Jan van Schooten and Günter Menz
    Citation: Respiratory Research 2014 15:136
  7. Family history of asthma and other allergic diseases have been linked to the risk of childhood asthma previously, but little is known about their effect on the age-of-onset and persistency of asthma until youn...

    Authors: Elina MS Paaso, Maritta S Jaakkola, Aino K Rantala, Timo T Hugg and Jouni JK Jaakkola
    Citation: Respiratory Research 2014 15:152

    The Erratum to this article has been published in Respiratory Research 2015 16:36

  8. Airway epithelium integrity is essential to maintain its role of mechanical and functional barrier. Recurrent epithelial injuries require a complex mechanism of repair to restore its integrity. In chronic obst...

    Authors: Jeanne-Marie Perotin, Damien Adam, Juliette Vella-Boucaud, Gonzague Delepine, Sebastian Sandu, Anne-Carole Jonvel, Alain Prevost, Gérard Berthiot, Christophe Pison, François Lebargy, Philippe Birembaut, Christelle Coraux and Gaëtan Deslee
    Citation: Respiratory Research 2014 15:151
  9. Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder marked by relative resistance to steroids. The IL-17 superfamily, which mediates cross-talk between the adaptive and innate immune syste...

    Authors: Ying Chang, Laila Al-Alwan, Sama Alshakfa, Severine Audusseau, Andrea Karen Mogas, Fazila Chouiali, Parameswaran Nair, Carolyn J Baglole, Qutayba Hamid and David H Eidelman
    Citation: Respiratory Research 2014 15:145
  10. In order to find novel noninvasive biomarkers with high accuracy for the screening of early-stage non-small cell lung cancer (NSCLC), we investigate the predictive power of 5 microRNAs (miR-20a, miR-145, miR-2...

    Authors: Qing Geng, Tao Fan, Boyou Zhang, Wei Wang, Yao Xu and Hao Hu
    Citation: Respiratory Research 2014 15:149
  11. High mobility group box-1 (HMGB1), a proinflammatory cytokine, plays a pivotal role in tissue remodeling and angiogenesis, both of which are crucial for the pathogenesis of pulmonary arterial hypertension. In ...

    Authors: Pil-Sung Yang, Dae-Hoon Kim, Yong Joon Lee, Sang-Eun Lee, Won Jun Kang, Hyuk-Jae Chang and Jeon-Soo Shin
    Citation: Respiratory Research 2014 15:148

    The Erratum to this article has been published in Respiratory Research 2016 17:142

  12. Chronic obstructive pulmonary disease (COPD) is a multifaceted condition that cannot be fully described by the severity of airway obstruction. The limitations of spirometry and clinical history have prompted r...

    Authors: Sofie Lock-Johansson, Jørgen Vestbo and Grith Lykke Sorensen
    Citation: Respiratory Research 2014 15:147
  13. Acute respiratory distress syndrome (ARDS) can result in a life-threatening form of respiratory failure, and established, effective pharmacotherapies are therefore urgently required. Quercetin is one of the mo...

    Authors: Koji Takashima, Miyoko Matsushima, Katsunori Hashimoto, Haruka Nose, Mitsuo Sato, Naozumi Hashimoto, Yoshinori Hasegawa and Tsutomu Kawabe
    Citation: Respiratory Research 2014 15:150
  14. Subepithelial fibrosis is a characteristic hallmark of airway remodeling in asthma. A critical regulator of fibrosis, transforming growth factor β (TGF-β), can induce airway remodeling in epithelial cells thro...

    Authors: Kimberly D Fischer and Devendra K Agrawal
    Citation: Respiratory Research 2014 15:146

    The Erratum to this article has been published in Respiratory Research 2015 16:139

  15. Immunoglobulin (Ig) E is well-known to play a critical role in allergic diseases. We investigated the association between longitudinal change in total IgE level and the asthma control in patients with adult as...

    Authors: Akihiko Tanaka, Megumi Jinno, Kuniaki Hirai, Yoshito Miyata, Hiroko Mizuma, Munehiro Yamaguchi, Shin Ohta, Yoshio Watanabe, Mayumi Yamamoto, Shintaro Suzuki, Takuya Yokoe, Mitsuru Adachi and Hironori Sagara
    Citation: Respiratory Research 2014 15:144
  16. Inhaled corticosteroids (ICS), especially when prescribed in combination with long-acting β2 agonists have been shown to improve COPD outcomes. Although there is consistent evidence linking ICS with adverse effec...

    Authors: Rob W Flynn, Thomas M MacDonald, Adrian Hapca, Isla S MacKenzie and Stuart Schembri
    Citation: Respiratory Research 2014 15:141
  17. Sputum induction is a non-invasive method for obtaining measurements of inflammation in the airways. Whether spontaneously sampled sputum can be a valid surrogate is unknown. The aim of this study was to compa...

    Authors: Solveig Tangedal, Marianne Aanerud, Louise JP Persson, Karl A Brokstad, Per S Bakke and Tomas M Eagan
    Citation: Respiratory Research 2014 15:138
  18. Epidemiological studies have revealed that intrauterine growth retardation (IUGR) or low birth weight is linked to the later development of asthma. Epigenetic regulatory mechanisms play an important role in th...

    Authors: Xue-Feng Xu, Qiong-Yao Hu, Ling-Fang Liang, Lei Wu, Wei-Zhong Gu, Li-Li Tang, Lin-Chen Fu and Li-Zhong Du
    Citation: Respiratory Research 2014 15:137
  19. In western countries, late-onset asthmatics are more severe than early-onset asthmatics in clinic-based studies. However, whether asthma occurrence rates were higher in late ages than in younger ages was incon...

    Authors: Tsung-Ju Wu, Chang-Fu Wu, Yungling Leo Lee, Tzuen-Ren Hsiue and Yue Leon Guo
    Citation: Respiratory Research 2014 15:135
  20. Acute respiratory distress syndrome (ARDS) is a life-threatening critical illness, characterised by qualitative and quantitative surfactant compositional changes associated with premature airway collapse, gas-...

    Authors: Ahilanandan Dushianthan, Victoria Goss, Rebecca Cusack, Michael PW Grocott and Anthony D Postle
    Citation: Respiratory Research 2014 15:128
  21. Reduced forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) are strong predictors of mortality and lung function is higher among individuals with exceptional longevity...

    Authors: Bharat Thyagarajan, Mary Wojczynski, Ryan L Minster, Jason Sanders, Sandra Barral, Lene Christiansen, R Graham Barr and Anne Newman
    Citation: Respiratory Research 2014 15:134
  22. Receptors for advanced glycation end-products (RAGE) are multiligand cell-surface receptors expressed abundantly by distal pulmonary epithelium. Our lab has discovered RAGE-mediated effects in the orchestratio...

    Authors: B Garrett Bodine, Brock G Bennion, Emma Leatham, Felix R Jimenez, Alex J Wright, Zac R Jergensen, Connor J Erickson, Cameron M Jones, Jeff P Johnson, Steven M Knapp and Paul R Reynolds
    Citation: Respiratory Research 2014 15:133
  23. Allergy and Aspergillus hypersensitivity (AH) were shown to be associated with severe symptoms or worse lung function in COPD patients. The prevalence of elevated total IgE (T-IgE) and its association with clinic...

    Authors: Jianmin Jin, Xiaofang Liu and Yongchang Sun
    Citation: Respiratory Research 2014 15:130
  24. CD86-CD28 interaction has been suggested as the principal costimulatory pathway for the activation and differentiation of naïve T cells in allergic inflammation. However, it remains uncertain whether this path...

    Authors: Yukari Asai-Tajiri, Koichiro Matsumoto, Satoru Fukuyama, Keiko Kan-o, Takako Nakano, Ken Tonai, Tatsukuni Ohno, Miyuki Azuma, Hiromasa Inoue and Yoichi Nakanishi
    Citation: Respiratory Research 2014 15:132
  25. Receptors for advanced glycation end-products (RAGE) are immunoglobulin-like pattern recognition receptors abundantly localized to lung epithelium. Our research demonstrated that primary tobacco smoke exposure...

    Authors: Duane R Winden, David B Barton, Bryce C Betteridge, Jared S Bodine, Cameron M Jones, Geraldine D Rogers, Michael Chavarria, Alex J Wright, Zac R Jergensen, Felix R Jimenez and Paul R Reynolds
    Citation: Respiratory Research 2014 15:129
  26. Few studies have investigated the 24-hour symptom profile in patients with COPD or how symptoms during the 24-hour day are inter-related. This observational study assessed the prevalence, severity and relation...

    Authors: Marc Miravitlles, Heinrich Worth, Juan José Soler Cataluña, David Price, Fernando De Benedetto, Nicolas Roche, Nina Skavlan Godtfredsen, Thys van der Molen, Claes-Göran Löfdahl, Laura Padullés and Anna Ribera
    Citation: Respiratory Research 2014 15:122
  27. In chronic obstructive pulmonary disease (COPD), two major pathological changes that occur are the loss of alveolar structure and airspace enlargement. To treat COPD, it is crucial to repair damaged lung tissu...

    Authors: Yaqing Li, Chao Gu, Wulin Xu, Jianping Yan, Yingjie Xia, Yingyu Ma, Chun Chen, Xujun He and Houquan Tao
    Citation: Respiratory Research 2014 15:120
  28. Combining two long-acting bronchodilators with complementary mechanisms of action may provide treatment benefits to patients with chronic obstructive pulmonary disease (COPD) that are greater than those derive...

    Authors: Anthony D D’Urzo, Stephen I Rennard, Edward M Kerwin, Victor Mergel, Anne R Leselbaum and Cynthia F Caracta
    Citation: Respiratory Research 2014 15:123
  29. Chronic obstructive pulmonary disease (COPD) is a phenotypically heterogeneous disease. In COPD, the presence of emphysema is associated with increased mortality and risk of lung cancer. High resolution comput...

    Authors: Brendan J Carolan, Grant Hughes, Jarrett Morrow, Craig P Hersh, Wanda K O’Neal, Stephen Rennard, Sreekumar G Pillai, Paula Belloni, Debra A Cockayne, Alejandro P Comellas, Meilan Han, Rachel L Zemans, Katerina Kechris and Russell P Bowler
    Citation: Respiratory Research 2014 15:127
  30. Cigarette smoking is the most important risk factor for Chronic Obstructive Pulmonary Disease (COPD). Only a subgroup of smokers develops COPD and it is unclear why these individuals are more susceptible to th...

    Authors: Susan JM Hoonhorst, Wim Timens, Leo Koenderman, Adèle T Lo Tam Loi, Jan-Willem J Lammers, H Marike Boezen, Antoon JM van Oosterhout, Dirkje S Postma and Nick HT ten Hacken
    Citation: Respiratory Research 2014 15:121
  31. Molecular mechanisms involved in the oxidative stress induced glucocorticoids insensitivity remain elusive. The mitogen-activated protein kinase phosphatase (MKP) 1 mediates a part of glucocorticoids action an...

    Authors: Aihua Bao, Feng Li, Min Zhang, Yuqing Chen, Pengyu Zhang and Xin Zhou
    Citation: Respiratory Research 2014 15:126
  32. Pulmonary arterial hypertension (PAH) is a proliferative arteriopathy associated with a glycolytic shift during heart metabolism. An increase in glycolytic metabolism can be detected in the right ventricle dur...

    Authors: Wei-hua Zhang, Mei-hong Qiu, Xiao-jian Wang, Kai Sun, Yang Zheng and Zhi-cheng Jing
    Citation: Respiratory Research 2014 15:119
  33. Severe Alpha-1 Antitrypsin (AAT) deficiency is a hereditary condition caused by mutations in the SERPINA1 gene, which predisposes to lung emphysema and liver disease. It is usually related to PI*Z alleles, and le...

    Authors: Beatriz Lara, Maria Teresa Martínez, Ignacio Blanco, Cristina Hernández-Moro, Eladio A Velasco, Ilaria Ferrarotti, Francisco Rodriguez-Frias, Laura Perez, Irene Vazquez, Javier Alonso, Manuel Posada and Beatriz Martínez-Delgado
    Citation: Respiratory Research 2014 15:125
  34. Symptomatic relief is an important treatment goal for patients with COPD. To date, no diary for evaluating respiratory symptoms in clinical trials has been developed and scientifically-validated according to F...

    Authors: Nancy K Leidy, Lindsey T Murray, Brigitta U Monz, Linda Nelsen, Mitchell Goldman, Paul W Jones, Elizabeth J Dansie and Sanjay Sethi
    Citation: Respiratory Research 2014 15:124
  35. We sought to assess whether the effects of mesenchymal stromal cells (MSC) on lung inflammation and remodeling in experimental emphysema would differ according to MSC source and administration route. Emphysema...

    Authors: Mariana A Antunes, Soraia C Abreu, Fernanda F Cruz, Ana Clara Teixeira, Miquéias Lopes-Pacheco, Elga Bandeira, Priscilla C Olsen, Bruno L Diaz, Christina M Takyia, Isalira PRG Freitas, Nazareth N Rocha, Vera L Capelozzi, Débora G Xisto, Daniel J Weiss, Marcelo M Morales and Patricia RM Rocco
    Citation: Respiratory Research 2014 15:118
  36. Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to i...

    Authors: Lu Yin, Dahai Zheng, Gino V Limmon, Nicola HN Leung, Shuoyu Xu, Jagath C Rajapakse, Hanry Yu, Vincent TK Chow and Jianzhu Chen
    Citation: Respiratory Research 2014 15:116
  37. Right ventricular dysfunction in COPD is common, even in the absence of pulmonary hypertension. The aim of the present study was to examine the effects of high intensity interval training (HIIT) on right ventr...

    Authors: Erlend Hassel, Anne Marie Berre, Anne Jarstein Skjulsvik and Sigurd Steinshamn
    Citation: Respiratory Research 2014 15:117
  38. Neutrophils have been involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Underlying mechanisms of neutrophil accumulation in the airways of stable and exacerbated COPD patients are p...

    Authors: Jean Louis Corhay, Catherine Moermans, Monique Henket, Delphine Nguyen Dang, Bernard Duysinx and Renaud Louis
    Citation: Respiratory Research 2014 15:115
  39. Patients with chronic obstructive pulmonary disease (COPD) often suffer concomitant disorders that worsen significantly their health status and vital prognosis. The pathogenic mechanisms underlying COPD multim...

    Authors: Solène Grosdidier, Antoni Ferrer, Rosa Faner, Janet Piñero, Josep Roca, Borja Cosío, Alvar Agustí, Joaquim Gea, Ferran Sanz and Laura I Furlong
    Citation: Respiratory Research 2014 15:111
  40. Inhaled long-acting beta2agonists used alone and in combination with an inhaled corticosteroid reduce the risk of exacerbations in patients with stable COPD. However, the relative efficacy of these agents in prev...

    Authors: Jill A Ohar, Glenn D Crater, Amanda Emmett, Thomas J Ferro, Andrea N Morris, Ibrahim Raphiou, Peruvemba S Sriram and Mark T Dransfield
    Citation: Respiratory Research 2014 15:105
  41. Aging involves multiple biologically complex processes characterized by a decline in cellular homeostasis over time leading to a loss and impairment of physiological integrity and function. Specific cellular h...

    Authors: Matthew S Walters, Bishnu P De, Jacqueline Salit, Lauren J Buro-Auriemma, Timothy Wilson, Allison M Rogalski, Lindsay Lief, Neil R Hackett, Michelle R Staudt, Ann E Tilley, Ben-Gary Harvey, Robert J Kaner, Jason G Mezey, Beth Ashbridge, Malcolm A S Moore and Ronald G Crystal
    Citation: Respiratory Research 2014 15:94
  42. Chronic bronchitis (CB) is one of the classic phenotypes of COPD. The aims of our study were to investigate genetic variants associated with COPD subjects with CB relative to smokers with normal spirometry, an...

    Authors: Jin Hwa Lee, Michael H Cho, Craig P Hersh, Merry-Lynn N McDonald, James D Crapo, Per S Bakke, Amund Gulsvik, Alejandro P Comellas, Christine H Wendt, David A Lomas, Victor Kim and Edwin K Silverman
    Citation: Respiratory Research 2014 15:113
  43. The low toxicity of perfluorocarbons (PFCs), their high affinity for respiratory gases and their compatibility with lung surfactant have made them useful candidates for treating respiratory diseases such as ad...

    Authors: Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis HY Green and Ken J Snibson
    Citation: Respiratory Research 2014 15:98
  44. There has been increasing interest in the use of newer, culture-independent techniques to study the airway microbiome of COPD patients. We investigated the relationships between the three common potentially pa...

    Authors: Richa Singh, Alexander J Mackay, Anant RC Patel, Davinder S Garcha, Beverly S Kowlessar, Simon E Brill, Louise E Donnelly, Peter J Barnes, Gavin C Donaldson and Jadwiga A Wedzicha
    Citation: Respiratory Research 2014 15:114
  45. Alpha-1 antitrypsin is the main inhibitor of neutrophil elastase in the lung. Although it is principally synthesized by hepatocytes, alpha-1 antitrypsin is also secreted by bronchial epithelial cells. Gene mut...

    Authors: Laura Pini, Laura Tiberio, Narayanan Venkatesan, Michela Bezzi, Luciano Corda, Maurizio Luisetti, Ilaria Ferrarotti, Mario Malerba, David A Lomas, Sabina Janciauskiene, Enrico Vizzardi, Denise Modina, Luisa Schiaffonati and Claudio Tantucci
    Citation: Respiratory Research 2014 15:112
  46. Lung immaturity due to preterm birth is a significant complication affecting neonatal health. Despite the detrimental effects of supplemental oxygen on alveolar formation, it remains an important treatment for...

    Authors: Christina V Jones, Maliha A Alikhan, Megan O’Reilly, Foula Sozo, Timothy M Williams, Richard Harding, Graham Jenkin and Sharon D Ricardo
    Citation: Respiratory Research 2014 15:110
  47. In moderate acute respiratory distress syndrome (ARDS) several studies support the usage of assisted spontaneous breathing modes. Only limited data, however, focus on the application in systemic sepsis and dev...

    Authors: Alexander Ziebart, Erik K Hartmann, Rainer Thomas, Tanghua Liu, Bastian Duenges, Arno Schad, Marc Bodenstein, Serge C Thal and Matthias David
    Citation: Respiratory Research 2014 15:101
  48. Chronic pulmonary obstructive disease (COPD) has become the fourth leading cause of death worldwide. Cigarette smoking induces neutrophil elastase (NE) and contributes to COPD, but the detailed mechanisms invo...

    Authors: Hsin-Han Hou, Shih-Lung Cheng, Kuei-Pin Chung, Shu-Chen Wei, Po-Nien Tsao, Hsuan-Hsuan Lu, Hao-Chien Wang and Chong-Jen Yu
    Citation: Respiratory Research 2014 15:106
  49. COPD patients have increased numbers of macrophages and neutrophils in the lungs. Interleukin-6 (IL-6) trans-signaling via its soluble receptor sIL-6R, governs the influx of innate immune cells to inflammatory fo...

    Authors: Arjun K Ravi, Shruti Khurana, Jonathan Lemon, Jonathan Plumb, George Booth, Louise Healy, Matthew Catley, Jørgen Vestbo and Dave Singh
    Citation: Respiratory Research 2014 15:103
  50. Mortality in non-cystic fibrosis bronchiectasis (NCFB) is known to be influenced by a number of factors such as gender, age, smoking history and Pseudomonas aeruginosa, but the impact of traffic related air pollu...

    Authors: Pieter C Goeminne, Esmee Bijnens, Ben Nemery, Tim S Nawrot and Lieven J Dupont
    Citation: Respiratory Research 2014 15:108

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