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  1. Research

    The role of serum procalcitonin in establishing the diagnosis and prognosis of pleural infection

    Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC)...

    Giles Dixon, Adriana Lama-Lopez, Oliver J. Bintcliffe, Anna J. Morley, Clare E. Hooper and Nick A. Maskell

    Respiratory Research 2017 18:30

    Published on: 3 February 2017

  2. Research

    High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis

    This study aims to use high throughput 16SrRNA gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between Propionib...

    Meng-Meng Zhao, Shan-Shan Du, Qiu-Hong Li, Tao Chen, Hui Qiu, Qin Wu, Shan-Shan Chen, Ying Zhou, Yuan Zhang, Yang Hu, Yi-Liang Su, Li Shen, Fen Zhang, Dong Weng and Hui-Ping Li

    Respiratory Research 2017 18:28

    Published on: 1 February 2017

  3. Letter to the Editor

    Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis

    Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an unidentifiable cause. They carry a significant mortality an...

    Philip L. Molyneaux, Michael J Cox, Athol U. Wells, Ho Cheol Kim, Wonjun Ji, William O. C. Cookson, Miriam F. Moffatt, Dong Soon Kim and Toby M. Maher

    Respiratory Research 2017 18:29

    Published on: 1 February 2017

  4. Research

    Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae

    Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus in...

    Maria C. Zarcone, Annemarie van Schadewijk, Evert Duistermaat, Pieter S. Hiemstra and Ingeborg M. Kooter

    Respiratory Research 2017 18:27

    Published on: 28 January 2017

  5. Research

    Pharmacological investigation on the anti-oxidant and anti-inflammatory activity of N-acetylcysteine in an ex vivo model of COPD exacerbation

    Oxidative stress is recognized to be one of predisposing factor in the pathogenesis of COPD. The oxidant/antioxidant imbalance is significantly pronounced in patients with COPD exacerbation. N-acetylcysteine (...

    Mario Cazzola, Luigino Calzetta, Francesco Facciolo, Paola Rogliani and Maria Gabriella Matera

    Respiratory Research 2017 18:26

    Published on: 24 January 2017

  6. Research

    Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma

    Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play key roles not only as homodimers but ...

    Utako Fujii, Nobuaki Miyahara, Akihiko Taniguchi, Naohiro Oda, Daisuke Morichika, Etsuko Murakami, Hikari Nakayama, Koichi Waseda, Mikio Kataoka, Hiroki Kakuta, Mitsune Tanimoto and Arihiko Kanehiro

    Respiratory Research 2017 18:23

    Published on: 23 January 2017

  7. Research

    Admission levels of asymmetric and symmetric dimethylarginine predict long-term outcome in patients with community-acquired pneumonia

    During infection, there is an activation of the L-arginine-nitric-oxide pathway, with a shift from nitric oxide synthesis to a degradation of L-arginine to its metabolites, asymmetric and symmetric dimethylarg...

    Alaadin Vögeli, Manuel Ottiger, Marc A. Meier, Christian Steuer, Luca Bernasconi, Prasad Kulkarni, Andreas Huber, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Robert Thomann, Werner Zimmerli, Beat Mueller and Philipp Schuetz

    Respiratory Research 2017 18:25

    Published on: 23 January 2017

  8. Research

    Biomarkers of extracellular matrix turnover are associated with emphysema and eosinophilic-bronchitis in COPD

    Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collage...

    Asger Reinstrup Bihlet, Morten Asser Karsdal, Jannie Marie Bülow Sand, Diana Julie Leeming, Mustimbo Roberts, Wendy White and Russell Bowler

    Respiratory Research 2017 18:22

    Published on: 19 January 2017

  9. Review

    Is aclidinium alone or combined with a LABA a rational choice for symptomatic COPD patients?

    As emphasized by international recommendations and largely confirmed by clinical experience, long-acting bronchodilators play a central role in the maintenance treatment of chronic obstructive pulmonary diseas...

    F. Blasi, G. W. Canonica and M. Miravitlles

    Respiratory Research 2017 18:19

    Published on: 18 January 2017

    The Erratum to this article has been published in Respiratory Research 2017 18:35

  10. Letter to the Editor

    Vascular function in asthmatic children and adolescents

    Epidemiological studies have demonstrated an increased incidence of cardiovascular events in patients with bronchial asthma, but little is known about the relationship between asthma and vascular function. The...

    Leonardo Silva Augusto, Grazielle Caroline Silva, José Felippe Pinho, Rosária Dias Aires, Virgínia Soares Lemos, Lidiana Fátima Correa Ramalho, Nulma Souto Jentzsch and Maria Glória Rodrigues-Machado

    Respiratory Research 2017 18:17

    Published on: 17 January 2017

  11. Research

    The St. George’s Respiratory Questionnaire as a prognostic factor in IPF

    It is unclear whether health related quality of life (HRQL) may have a predictive value for mortality in idiopathic pulmonary fibrosis (IPF).

    Taiki Furukawa, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Kensuke Kataoka, Osamu Nishiyama, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto and Yoshinori Hasegawa

    Respiratory Research 2017 18:18

    Published on: 17 January 2017

  12. Research

    Comparing accelerometer, pedometer and a questionnaire for measuring physical activity in bronchiectasis: a validity and feasibility study

    There are challenges for researchers and clinicians to select the most appropriate physical activity tool, and a balance between precision and feasibility is needed. Currently it is unclear which physical acti...

    B. O’Neill, S. M. McDonough, J. J. Wilson, I. Bradbury, K. Hayes, A. Kirk, L. Kent, D. Cosgrove, J. M. Bradley and M. A. Tully

    Respiratory Research 2017 18:16

    Published on: 14 January 2017

  13. Research

    Regulatory T cells and IL10 suppress pulmonary host defense during early-life exposure to radical containing combustion derived ultrafine particulate matter

    Exposure to elevated levels of particulate matter (PM) is associated with increased risk of morbidity and mortality due to respiratory tract viral infections in infants. Recent identification of environmentall...

    Sridhar Jaligama, Jordy Saravia, Dahui You, Nikki Yadav, Greg I. Lee, Bishwas Shrestha and Stephania A. Cormier

    Respiratory Research 2017 18:15

    Published on: 13 January 2017

  14. Research

    Transfer factor for carbon monoxide in patients with COPD and diabetes: results from the German COSYCONET cohort

    An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes.

    Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M. Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F. M. Wouters, Claus Vogelmeier…

    Respiratory Research 2017 18:14

    Published on: 13 January 2017

  15. Research

    Indacaterol and glycopyrronium versus indacaterol on body plethysmography measurements in COPD—a randomised controlled study

    Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on l...

    Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J. Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens and Martin Brutsche

    Respiratory Research 2017 18:13

    Published on: 11 January 2017

  16. Research

    Whole Transcriptome Analysis of Pre-invasive and Invasive Early Squamous Lung Carcinoma in Archival Laser Microdissected Samples

    Preinvasive squamous cell cancer (PSCC) are local transformations of bronchial epithelia that are frequently observed in current or former smokers. Their different grades and sizes suggest a continuum of dyspl...

    Andre Koper, Leo A. H. Zeef, Leena Joseph, Keith Kerr, John Gosney, Mark A. Lindsay and Richard Booton

    Respiratory Research 2017 18:12

    Published on: 10 January 2017

  17. Research

    End-stage cystic fibrosis lung disease is characterised by a diverse inflammatory pattern: an immunohistochemical analysis

    Cystic fibrosis (CF) lung disease is characterised by vigorous airway inflammation eventually resulting in severe lung damage. This study aimed to describe the diversity of the inflammatory pattern in end-stag...

    Elise J. Lammertyn, Elly Vandermeulen, Hannelore Bellon, Stephanie Everaerts, Stijn E. Verleden, Kathleen Van Den Eynde, Ken R. Bracke, Guy G. Brusselle, Pieter C. Goeminne, Erik K. Verbeken, Bart M. Vanaudenaerde and Lieven J. Dupont

    Respiratory Research 2017 18:10

    Published on: 10 January 2017

  18. Research

    A randomized, seven-day study to assess the efficacy and safety of a glycopyrrolate/formoterol fumarate fixed-dose combination metered dose inhaler using novel Co-Suspension™ Delivery Technology in patients with moderate-to-very severe chronic obstructive pulmonary disease

    Long-acting muscarinic antagonist/long-acting β2-agonist combinations are recommended for patients whose chronic obstructive pulmonary disease (COPD) is not managed with monotherapy. We assessed the efficacy and ...

    Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden and Sarvajna Dwivedi

    Respiratory Research 2017 18:8

    Published on: 6 January 2017

    The Erratum to this article has been published in Respiratory Research 2017 18:158

  19. Research

    Cigarette smoke destabilizes NLRP3 protein by promoting its ubiquitination

    Cigarette smoke suppresses innate immunity, making smokers more susceptible to infection. The NLRP3 inflammasome is a multi-protein complex that releases interleukin (IL) -1β and IL -18. These cytokines are cr...

    SeungHye Han, Jacob A. Jerome, Alyssa D. Gregory and Rama K. Mallampalli

    Respiratory Research 2017 18:2

    Published on: 5 January 2017

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