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  1. Content type: Letter to the Editor

    Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and plexiform lesions. Multiple-p...

    Authors: Florence Coste, Christelle Guibert, Julie Magat, Emma Abell, Fanny Vaillant, Mathilde Dubois, Arnaud Courtois, Philippe Diolez, Bruno Quesson, Roger Marthan, Jean-Pierre Savineau, Bernard Muller and Véronique Freund-Michel

    Citation: Respiratory Research 2017 18:47

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  2. Content type: Research

    Airway fibrosis is one of the pathological features of chronic obstructive pulmonary disease (COPD), and recent studies revealed that acetylcholine plays an important role in the development of airway remodeli...

    Authors: Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu and Kazuhisa Takahashi

    Citation: Respiratory Research 2017 18:46

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  3. Content type: Research

    Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF) using computed tomography (CT) have often used subjective analyses or have evaluated quantitative measures in isolation. This st...

    Authors: Samuel Y. Ash, Rola Harmouche, Diego Lassala Lopez Vallejo, Julian A. Villalba, Kris Ostridge, River Gunville, Carolyn E. Come, Jorge Onieva Onieva, James C. Ross, Gary M. Hunninghake, Souheil Y. El-Chemaly, Tracy J. Doyle, Pietro Nardelli, Gonzalo V. Sanchez-Ferrero, Hilary J. Goldberg, Ivan O. Rosas…

    Citation: Respiratory Research 2017 18:45

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  4. Content type: Letter to the Editor

    Severe asthma is characterised by a variety of symptoms, which include chronic cough, however the mechanisms responsible for cough reflex hypersensitivity in asthma remain poorly elucidated. Current asthma pat...

    Authors: Sushiladevi Natarajan, Robert C. Free, Peter Bradding, Lorcan McGarvey and Salman Siddiqui

    Citation: Respiratory Research 2017 18:44

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  5. Content type: Research

    Solitary fibrous tumors of the pleura (SFTP) are rare neoplasia of the chest. A subset of SFTP follows a malignant course, sometimes several years after complete resection. Traditional scoring systems based on...

    Authors: Matthias Brock, Selma Hottinger, Matthias Diebold, Alex Soltermann, Wolfram Jochum, Malcolm Kohler, Lars C. Huber and Daniel P. Franzen

    Citation: Respiratory Research 2017 18:43

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  6. Content type: Research

    Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unkno...

    Authors: Carlos H. Martinez, Christine M. Freeman, Joshua D. Nelson, Susan Murray, Xin Wang, Matthew J. Budoff, Mark T. Dransfield, John E. Hokanson, Ella A. Kazerooni, Gregory L. Kinney, Elizabeth A. Regan, J. Michael Wells, Fernando J. Martinez, MeiLan K. Han and Jeffrey L. Curtis

    Citation: Respiratory Research 2017 18:42

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  7. Content type: Research

    Asthma is characterized by a heterogeneous inflammatory profile and can be subdivided into T(h)2-high and T(h)2-low airway inflammation. Profiling of a broader panel of airway cytokines in large unselected pat...

    Authors: Sven F. Seys, Hans Scheers, Paul Van den Brande, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter C. Goeminne, Peter W Hellings, Jan L. Ceuppens, Lieven J Dupont and Dominique M. A. Bullens

    Citation: Respiratory Research 2017 18:39

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  8. Content type: Research

    It is known that tissue macrophages derive not only from blood monocytes but also from yolk sac or fetal liver, and the tissue of residence guides their function. When isolated, they lose tissue specific signa...

    Authors: Erica Bazzan, Graziella Turato, Mariaenrica Tinè, Claudia M. Radu, Elisabetta Balestro, Chiara Rigobello, Davide Biondini, Marco Schiavon, Francesca Lunardi, Simonetta Baraldo, Federico Rea, Paolo Simioni, Fiorella Calabrese, Marina Saetta and Manuel G. Cosio

    Citation: Respiratory Research 2017 18:40

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  9. Content type: Research

    Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was un...

    Authors: Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann and Fang Yang

    Citation: Respiratory Research 2017 18:38

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  10. Content type: Research

    Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma severity. Macrolides have immunomodulatory effects and a...

    Authors: Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-ichi Kadota, Bruce K. Rubin and Kenji Izuhara

    Citation: Respiratory Research 2017 18:37

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  11. Content type: Research

    Co-exposure to cigarette smoke and alcohol leads to the generation of high concentrations of acetaldehyde and malondialdehyde in the lung. These aldehydes being highly electrophilic in nature react with biolog...

    Authors: Muna Sapkota, Jane M. DeVasure, Kusum K. Kharbanda and Todd A. Wyatt

    Citation: Respiratory Research 2017 18:36

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  12. Content type: Research

    The International Classification of Diseases (ICD) has been grouping the allergic and hypersensitivity disorders involving the respiratory tract under topographic distribution, regardless of the underlying mec...

    Authors: Luciana Kase Tanno, Moises Calderon, Jeffrey F. Linzer Sr, Robert J.G. Chalmers and Pascal Demoly

    Citation: Respiratory Research 2017 18:34

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  13. Content type: Letter to the Editor

    We designed a crossover and placebo-controlled trial to investigate the impact of a 1-h acute vaping session of nicotine-free and flavour-free e-liquid on the pulmonary functions and respiratory mechanics of h...

    Authors: Marie-Ève Boulay, Cyndi Henry, Ynuk Bossé, Louis-Philippe Boulet and Mathieu C. Morissette

    Citation: Respiratory Research 2017 18:33

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  14. Content type: Research

    Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-der...

    Authors: Nina A. Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W. Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin and Annette D. Rieg

    Citation: Respiratory Research 2017 18:32

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    The Erratum to this article has been published in Respiratory Research 2017 18:121

  15. Content type: Research

    COPD often coexists with chronic conditions that may influence disease prognosis. We investigated associations between chronic (co)morbidities and exacerbations in primary care COPD patients.

    Authors: Janine A. M. Westerik, Esther I. Metting, Job F. M. van Boven, Waling Tiersma, Janwillem W. H. Kocks and Tjard R. Schermer

    Citation: Respiratory Research 2017 18:31

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  16. Content type: Research

    Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC)...

    Authors: Giles Dixon, Adriana Lama-Lopez, Oliver J. Bintcliffe, Anna J. Morley, Clare E. Hooper and Nick A. Maskell

    Citation: Respiratory Research 2017 18:30

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  17. Content type: Research

    This study aims to use high throughput 16SrRNA gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between Propionib...

    Authors: Meng-Meng Zhao, Shan-Shan Du, Qiu-Hong Li, Tao Chen, Hui Qiu, Qin Wu, Shan-Shan Chen, Ying Zhou, Yuan Zhang, Yang Hu, Yi-Liang Su, Li Shen, Fen Zhang, Dong Weng and Hui-Ping Li

    Citation: Respiratory Research 2017 18:28

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  18. Content type: Letter to the Editor

    Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an unidentifiable cause. They carry a significant mortality an...

    Authors: Philip L. Molyneaux, Michael J Cox, Athol U. Wells, Ho Cheol Kim, Wonjun Ji, William O. C. Cookson, Miriam F. Moffatt, Dong Soon Kim and Toby M. Maher

    Citation: Respiratory Research 2017 18:29

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  19. Content type: Research

    Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus in...

    Authors: Maria C. Zarcone, Annemarie van Schadewijk, Evert Duistermaat, Pieter S. Hiemstra and Ingeborg M. Kooter

    Citation: Respiratory Research 2017 18:27

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  20. Content type: Research

    Oxidative stress is recognized to be one of predisposing factor in the pathogenesis of COPD. The oxidant/antioxidant imbalance is significantly pronounced in patients with COPD exacerbation. N-acetylcysteine (...

    Authors: Mario Cazzola, Luigino Calzetta, Francesco Facciolo, Paola Rogliani and Maria Gabriella Matera

    Citation: Respiratory Research 2017 18:26

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  21. Content type: Research

    Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play key roles not only as homodimers but ...

    Authors: Utako Fujii, Nobuaki Miyahara, Akihiko Taniguchi, Naohiro Oda, Daisuke Morichika, Etsuko Murakami, Hikari Nakayama, Koichi Waseda, Mikio Kataoka, Hiroki Kakuta, Mitsune Tanimoto and Arihiko Kanehiro

    Citation: Respiratory Research 2017 18:23

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  22. Content type: Research

    During infection, there is an activation of the L-arginine-nitric-oxide pathway, with a shift from nitric oxide synthesis to a degradation of L-arginine to its metabolites, asymmetric and symmetric dimethylarg...

    Authors: Alaadin Vögeli, Manuel Ottiger, Marc A. Meier, Christian Steuer, Luca Bernasconi, Prasad Kulkarni, Andreas Huber, Mirjam Christ-Crain, Christoph Henzen, Claus Hoess, Robert Thomann, Werner Zimmerli, Beat Mueller and Philipp Schuetz

    Citation: Respiratory Research 2017 18:25

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  23. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is characterized by airflow obstruction and loss of lung tissue mainly consisting of extracellular matrix (ECM). Three of the main ECM components are type I collage...

    Authors: Asger Reinstrup Bihlet, Morten Asser Karsdal, Jannie Marie Bülow Sand, Diana Julie Leeming, Mustimbo Roberts, Wendy White and Russell Bowler

    Citation: Respiratory Research 2017 18:22

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  24. Content type: Review

    As emphasized by international recommendations and largely confirmed by clinical experience, long-acting bronchodilators play a central role in the maintenance treatment of chronic obstructive pulmonary diseas...

    Authors: F. Blasi, G. W. Canonica and M. Miravitlles

    Citation: Respiratory Research 2017 18:19

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    The Erratum to this article has been published in Respiratory Research 2017 18:35

  25. Content type: Research

    Bronchial asthma is a chronic inflammatory and remodeling disorder of the airways, in which many cells, cellular elements, and cytokines play important roles. Stem cell factor (SCF) may contribute to the infla...

    Authors: Safaa I. Tayel, Sally M. El-Hefnway, Eman M. Abd El Gayed and Gehan A. Abdelaal

    Citation: Respiratory Research 2017 18:21

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  26. Content type: Letter to the Editor

    Epidemiological studies have demonstrated an increased incidence of cardiovascular events in patients with bronchial asthma, but little is known about the relationship between asthma and vascular function. The...

    Authors: Leonardo Silva Augusto, Grazielle Caroline Silva, José Felippe Pinho, Rosária Dias Aires, Virgínia Soares Lemos, Lidiana Fátima Correa Ramalho, Nulma Souto Jentzsch and Maria Glória Rodrigues-Machado

    Citation: Respiratory Research 2017 18:17

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  27. Content type: Research

    It is unclear whether health related quality of life (HRQL) may have a predictive value for mortality in idiopathic pulmonary fibrosis (IPF).

    Authors: Taiki Furukawa, Hiroyuki Taniguchi, Masahiko Ando, Yasuhiro Kondoh, Kensuke Kataoka, Osamu Nishiyama, Takeshi Johkoh, Junya Fukuoka, Koji Sakamoto and Yoshinori Hasegawa

    Citation: Respiratory Research 2017 18:18

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  28. Content type: Research

    There are challenges for researchers and clinicians to select the most appropriate physical activity tool, and a balance between precision and feasibility is needed. Currently it is unclear which physical acti...

    Authors: B. O’Neill, S. M. McDonough, J. J. Wilson, I. Bradbury, K. Hayes, A. Kirk, L. Kent, D. Cosgrove, J. M. Bradley and M. A. Tully

    Citation: Respiratory Research 2017 18:16

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  29. Content type: Research

    Exposure to elevated levels of particulate matter (PM) is associated with increased risk of morbidity and mortality due to respiratory tract viral infections in infants. Recent identification of environmentall...

    Authors: Sridhar Jaligama, Jordy Saravia, Dahui You, Nikki Yadav, Greg I. Lee, Bishwas Shrestha and Stephania A. Cormier

    Citation: Respiratory Research 2017 18:15

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  30. Content type: Research

    An impairment of CO diffusing capacity has been shown in diabetic patients without lung disease. We analyzed how diffusing capacity in patients with COPD is affected by the concurrent diagnosis of diabetes.

    Authors: Kathrin Kahnert, Tanja Lucke, Frank Biertz, Andreas Lechner, Henrik Watz, Peter Alter, Robert Bals, Jürgen Behr, Rolf Holle, Rudolf M. Huber, Stefan Karrasch, Beate Stubbe, Margarethe Wacker, Sandra Söhler, Emiel F. M. Wouters, Claus Vogelmeier…

    Citation: Respiratory Research 2017 18:14

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  31. Content type: Research

    Dual bronchodilator therapy is recommended for symptomatic patients with chronic obstructive pulmonary disease (COPD). There are limited data on effects of a combination of two long-acting bronchodilators on l...

    Authors: Joerg Salomon, Daiana Stolz, Guido Domenighetti, Jean-Georges Frey, Alexander J. Turk, Andrea Azzola, Thomas Sigrist, Jean-William Fitting, Ulrich Schmidt, Thomas Geiser, Corinne Wild, Konstantinos Kostikas, Andreas Clemens and Martin Brutsche

    Citation: Respiratory Research 2017 18:13

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  32. Content type: Research

    Preinvasive squamous cell cancer (PSCC) are local transformations of bronchial epithelia that are frequently observed in current or former smokers. Their different grades and sizes suggest a continuum of dyspl...

    Authors: Andre Koper, Leo A. H. Zeef, Leena Joseph, Keith Kerr, John Gosney, Mark A. Lindsay and Richard Booton

    Citation: Respiratory Research 2017 18:12

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  33. Content type: Research

    Cystic fibrosis (CF) lung disease is characterised by vigorous airway inflammation eventually resulting in severe lung damage. This study aimed to describe the diversity of the inflammatory pattern in end-stag...

    Authors: Elise J. Lammertyn, Elly Vandermeulen, Hannelore Bellon, Stephanie Everaerts, Stijn E. Verleden, Kathleen Van Den Eynde, Ken R. Bracke, Guy G. Brusselle, Pieter C. Goeminne, Erik K. Verbeken, Bart M. Vanaudenaerde and Lieven J. Dupont

    Citation: Respiratory Research 2017 18:10

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  34. Content type: Research

    Respiratory symptoms are associated with accelerated lung function decline, and increased hospitalization and mortality rates in the general population. Although several environmental risk factors for respirat...

    Authors: Xiang Zeng, Judith M. Vonk, Kim de Jong, Xijin Xu, Xia Huo and H. Marike Boezen

    Citation: Respiratory Research 2017 18:11

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  35. Content type: Research

    Specific resistance loops appear in different shapes influenced by different resistive properties of the airways, yet their descriptive ability is compressed to a single parameter - its slope. We aimed to deve...

    Authors: Marko Topalovic, Vasileios Exadaktylos, Thierry Troosters, Geert Celis, Jean-Marie Aerts and Wim Janssens

    Citation: Respiratory Research 2017 18:9

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  36. Content type: Research

    Long-acting muscarinic antagonist/long-acting β2-agonist combinations are recommended for patients whose chronic obstructive pulmonary disease (COPD) is not managed with monotherapy. We assessed the efficacy and ...

    Authors: Colin Reisner, Leonardo M. Fabbri, Edward M. Kerwin, Charles Fogarty, Selwyn Spangenthal, Klaus F. Rabe, Gary T. Ferguson, Fernando J. Martinez, James F. Donohue, Patrick Darken, Earl St. Rose, Chad Orevillo, Shannon Strom, Tracy Fischer, Michael Golden and Sarvajna Dwivedi

    Citation: Respiratory Research 2017 18:8

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    The Erratum to this article has been published in Respiratory Research 2017 18:158

  37. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is characterized by the complex interaction of cells involved in chronic inflammation and fibrosis. Global gene expression of a homogenous cell population will identify nove...

    Authors: Jong-Uk Lee, Hyun Sub Cheong, Eun-Young Shim, Da-Jeong Bae, Hun Soo Chang, Soo-Taek Uh, Young Hoon Kim, Jong-Sook Park, Bora Lee, Hyoung Doo Shin and Choon-Sik Park

    Citation: Respiratory Research 2017 18:3

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  38. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is a progressive, irreversible chronic inflammatory disorder typified by increased recruitment of monocytes, lymphocytes and neutrophils. Because of this, as well a...

    Authors: Xiaomin Dang, Xiaoyan Qu, Weijia Wang, Chongbing Liao, Ying Li, Xiaojin Zhang, Dan Xu, Carolyn J. Baglole, Dong Shang and Ying Chang

    Citation: Respiratory Research 2017 18:4

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  39. Content type: Research

    Asthma is a chronic respiratory disease characterized by reversible airway obstruction with persistent airway inflammation and airway remodeling, which is associated with increased airway smooth muscle (ASM) m...

    Authors: Sung-Ho Kim, Qing-Mei Pei, Ping Jiang, Min Yang, Xue-Jiao Qian and Jiang-Bo Liu

    Citation: Respiratory Research 2017 18:7

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  40. Content type: Research

    ICAM-1 is a major receptor for ~60% of human rhinoviruses, and non-typeable Haemophilus influenzae, two major pathogens in COPD. Increased cell-surface expression of ICAM-1 in response to tobacco smoke exposure h...

    Authors: Shakti Dhar Shukla, Malik Quasir Mahmood, Steven Weston, Roger Latham, Hans Konrad Muller, Sukhwinder Singh Sohal and Eugene Haydn Walters

    Citation: Respiratory Research 2017 18:6

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  41. Content type: Research

    Pulmonary fibrosis is a life-threatening disease characterized by progressive dyspnea and worsening pulmonary function. Atrial natriuretic peptide (ANP), a heart-derived secretory peptide used clinically in Ja...

    Authors: Atsuko Okamoto, Takashi Nojiri, Kazuhisa Konishi, Takeshi Tokudome, Koichi Miura, Hiroshi Hosoda, Jun Hino, Mikiya Miyazato, Yohkoh Kyomoto, Kazuhisa Asai, Kazuto Hirata and Kenji Kangawa

    Citation: Respiratory Research 2017 18:1

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  42. Content type: Research

    Electronic cigarettes (ECs) are battery-operated devices designed to vaporise nicotine, which may help smokers quitting or reducing their tobacco consumption. There is a lack of data on the health effects of E...

    Authors: Riccardo Polosa, Jaymin Bhagwanji Morjaria, Pasquale Caponnetto, Umberto Prosperini, Cristina Russo, Alfio Pennisi and Cosimo Marcello Bruno

    Citation: Respiratory Research 2016 17:166

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  43. Content type: Research

    Asthma is a disease of varying severity and differing disease mechanisms. To date, studies aimed at stratifying asthma into clinically useful phenotypes have produced a number of phenotypes that have yet to be...

    Authors: Matthew J. Loza, Ratko Djukanovic, Kian Fan Chung, Daniel Horowitz, Keying Ma, Patrick Branigan, Elliot S. Barnathan, Vedrana S. Susulic, Philip E. Silkoff, Peter J. Sterk and Frédéric Baribaud

    Citation: Respiratory Research 2016 17:165

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  44. Content type: Research

    Organ regeneration in mammals is hypothesized to require a functional pool of stem or progenitor cells, but the role of these cells in lung regeneration is unknown.

    Authors: Ling Zeng, Xue-tao Yang, Hai-sheng Li, Yong Li, Ce Yang, Wei Gu, Yin-han Zhou, Juan Du, Hai-yan Wang, Jian-hui Sun, Da-lin Wen and Jian-xin Jiang

    Citation: Respiratory Research 2016 17:164

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