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Respiratory Research

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  1. Content type: Research

    It has been observed that mice lacking the sulfatase modifying factor (Sumf1) developed an emphysema-like phenotype. However, it is unknown if SUMF1 may play a role in Chronic Obstructive Pulmonary Disease (COPD)...

    Authors: Julie Weidner, Linnea Jarenbäck, Kim de Jong, Judith M. Vonk, Maarten van den Berge, Corry-Anke Brandsma, H. Marike Boezen, Don Sin, Yohan Bossé, David Nickle, Jaro Ankerst, Leif Bjermer, Dirkje S. Postma, Alen Faiz and Ellen Tufvesson

    Citation: Respiratory Research 2017 18:77

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  2. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by an unpredictable course. Prognostic markers and disease activity markers are needed. The purpose of this single-center retrospectiv...

    Authors: Aurélien Justet, Astrid Laurent-Bellue, Gabriel Thabut, Arnaud Dieudonné, Marie-Pierre Debray, Raphael Borie, Michel Aubier, Rachida Lebtahi and Bruno Crestani

    Citation: Respiratory Research 2017 18:74

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  3. Content type: Letter to the Editor

    Eosinophilic COPD appears to be a distinct patient subgroup with an increased corticosteroid response. Eosinophilic COPD has been labelled as part of the asthma COPD overlap syndrome (ACOS). We compared the cl...

    Authors: Umme Kolsum, Arjun Ravi, Paul Hitchen, Satyanarayana Maddi, Thomas Southworth and Dave Singh

    Citation: Respiratory Research 2017 18:73

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  4. Content type: Research

    Chronic obstructive pulmonary disease (COPD) is currently the third leading cause of death and there is a huge unmet clinical need to identify disease biomarkers in peripheral blood. Compared to gene level dif...

    Authors: Ma’en Obeidat, Yunlong Nie, Virginia Chen, Casey P. Shannon, Anand Kumar Andiappan, Bernett Lee, Olaf Rotzschke, Peter J. Castaldi, Craig P. Hersh, Nick Fishbane, Raymond T. Ng, Bruce McManus, Bruce E. Miller, Stephen Rennard, Peter D. Paré and Don D. Sin

    Citation: Respiratory Research 2017 18:72

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  5. Content type: Research

    Emerging evidence reveals that nicotinamide phosphoribosyltransferase (NAMPT) has a significant role in the pathophysiology of the inflammatory process. NAMPT inhibition has a beneficial effect in the treatmen...

    Authors: Geng-Chin Wu, Wen-I Liao, Shu-Yu Wu, Hsin-Ping Pao, Shih-En Tang, Min-Hui Li, Kun-Lun Huang and Shi-Jye Chu

    Citation: Respiratory Research 2017 18:71

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  6. Content type: Research

    Rab38 small GTPase regulates intracellular transport in melanocytes and alveolar type II epithelial cells. Ruby rats carrying Rab38 and other gene mutations exhibit oculocutaneous albinism, bleeding diathesis, an...

    Authors: Kazuhiro Osanai, Keisuke Nakase, Takashi Sakuma, Kazuaki Nishiki, Masafumi Nojiri, Ryo Kato, Masatoshi Saito, Yuki Fujimoto, Shiro Mizuno and Hirohisa Toga

    Citation: Respiratory Research 2017 18:70

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  7. Content type: Review

    Chronic obstructive pulmonary disease (COPD) imposes a substantial burden on individuals with the disease, which can include a range of symptoms (breathlessness, cough, sputum production, wheeze, chest tightne...

    Authors: Marc Miravitlles and Anna Ribera

    Citation: Respiratory Research 2017 18:67

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  8. Content type: Research

    The effectiveness of early pulmonary rehabilitation (PR) for exacerbation of chronic obstructive pulmonary disease (COPD) remains controversial. The present study aimed to compare the outcomes between early an...

    Authors: Hiroki Matsui, Taisuke Jo, Kiyohide Fushimi and Hideo Yasunaga

    Citation: Respiratory Research 2017 18:68

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  9. Content type: Research

    Aldehyde dehydrogenases (ALDHs) play a major role in detoxification of aldehydes. High expression of ALDHs is a marker for stem cells of many organs including the lungs. A common polymorphism in ALDH2 gene (ALDH2...

    Authors: Aoi Kuroda, Ahmed E. Hegab, Gao Jingtao, Shuji Yamashita, Nobuyuki Hizawa, Tohru Sakamoto, Hideyasu Yamada, Satoshi Suzuki, Makoto Ishii, Ho Namkoong, Takanori Asakura, Mari Ozaki, Hiroyuki Yasuda, Junko Hamamoto, Shizuko Kagawa, Kenzo Soejima…

    Citation: Respiratory Research 2017 18:69

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  10. Content type: Research

    Avian antigen is a common cause of hypersensitivity pneumonitis (HP). Inhalation challenge with pigeon serum and pigeon dropping extract (PDE) elicits a hypersensitivity reaction in patients with bird-related ...

    Authors: Tsuyoshi Shirai, Haruhiko Furusawa, Asuka Furukawa, Yuki Ishige, Keisuke Uchida, Yasunari Miyazaki, Yoshinobu Eishi and Naohiko Inase

    Citation: Respiratory Research 2017 18:65

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  11. Content type: Research

    The patterns of mandibular movements (MM) during sleep can be used to identify increased respiratory effort periodic large-amplitude MM (LPM), and cortical arousals associated with “sharp” large-amplitude MM (...

    Authors: Jean-Benoît Martinot, Jean-Christian Borel, Nhat-Nam Le-Dong, Hervé Jean-Pierre Guénard, Valerie Cuthbert, Philip E. Silkoff, David Gozal and Jean-Louis Pepin

    Citation: Respiratory Research 2017 18:66

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  12. Content type: Research

    Interleukin 6 (IL-6) is a predictive factor of poor prognosis in patients with acute respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects and role in lung injury have not been...

    Authors: Guillaume Voiriot, Keyvan Razazi, Valérie Amsellem, Jeanne Tran Van Nhieu, Shariq Abid, Serge Adnot, Armand Mekontso Dessap and Bernard Maitre

    Citation: Respiratory Research 2017 18:64

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  13. Content type: Research

    Both short and long-term exposure to traffic-related air pollutants have been associated with asthma and reduced lung function. We hypothesized that short-term indoor exposure to fine particulate matter <2.5 μ...

    Authors: Kyung Hwa Jung, David Torrone, Stephanie Lovinsky-Desir, Matthew Perzanowski, Joshua Bautista, Jacqueline R. Jezioro, Lori Hoepner, Jamie Ross, Frederica P. Perera, Steven N. Chillrud and Rachel L. Miller

    Citation: Respiratory Research 2017 18:63

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  14. Content type: Research

    Chronic Obstructive Pulmonary Disease (COPD) may be associated with accelerated aging. Telomere shortening is a biomarker of aging. Cross-sectional studies describe shorter telomeres in COPD compared with matc...

    Authors: Elizabeth Córdoba-Lanús, Sara Cazorla-Rivero, Adriana Espinoza-Jiménez, Juan P. de-Torres, María J. Pajares, Armando Aguirre-Jaime, Bartolomé Celli and Ciro Casanova

    Citation: Respiratory Research 2017 18:59

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    The Erratum to this article has been published in Respiratory Research 2017 18:113

  15. Content type: Review

    Malignant pleural mesothelioma (MPM) is a rare and highly drug resistant tumor arising from the mesothelial surfaces of the lung pleura. The standard method to confirm MPM is the tedious, time-consuming cytolo...

    Authors: Lourdes Cortes-Dericks and Ralph Alexander Schmid

    Citation: Respiratory Research 2017 18:58

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  16. Content type: Research

    Researchers investigating lung diseases, such as asthma, have questioned whether certain compounds previously reported in exhaled breath condensate (EBC) originate from saliva contamination. Moreover, despite ...

    Authors: Charmion Cruickshank-Quinn, Michael Armstrong, Roger Powell, Joe Gomez, Marc Elie and Nichole Reisdorph

    Citation: Respiratory Research 2017 18:57

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  17. Content type: Research

    The incidence of asthma is increasing at an alarming rate. While the current available therapies are effective, there are associated side effects and they fail to adequately control symptoms in all patient sub...

    Authors: Katie Baker, Kristof Raemdonck, Robert J. Snelgrove, Maria G. Belvisi and Mark A. Birrell

    Citation: Respiratory Research 2017 18:55

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  18. Content type: Research

    Ku80 is a DNA repair protein which involves in cell apoptosis and chemoresistance. However, it is unclear whether Ku80 correlates with the efficiency of neoadjuvant chemotherapy in human lung adenocarcinoma, a...

    Authors: Bin Shang, Yang Jia, Gang Chen and Zhou Wang

    Citation: Respiratory Research 2017 18:56

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  19. Content type: Research

    Right ventricular structure and function is a major predictor of outcomes in pulmonary hypertension (PH), yet the underlying mechanisms remain poorly understood. Growing evidence suggests the importance of aut...

    Authors: Yan Deng, Weifeng Wu, Shenglan Guo, Yuming Chen, Chang Liu, Xingcui Gao and Bin Wei

    Citation: Respiratory Research 2017 18:53

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  20. Content type: Research

    Lung cancer (LC) is still the most common cause of cancer related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 85% of all LC cases but is not a single entity. It is now accepted that, apar...

    Authors: M. Vesel, J. Rapp, D. Feller, E. Kiss, L. Jaromi, M. Meggyes, G. Miskei, B. Duga, G. Smuk, T. Laszlo, I. Karner and J.E. Pongracz

    Citation: Respiratory Research 2017 18:52

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  21. Content type: Research

    Although caffeine and glucocorticoids are frequently used to treat chronic lung disease in preterm neonates, potential interactions are largely unknown. While anti-inflammatory effects of glucocorticoids are w...

    Authors: Markus Fehrholz, Kirsten Glaser, Christian P. Speer, Silvia Seidenspinner, Barbara Ottensmeier and Steffen Kunzmann

    Citation: Respiratory Research 2017 18:51

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