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  1. Type 2 alveolar epithelial cells (AT2s) behave as stem cells and show clonal proliferation upon alveolar injury followed by trans-differentiation (TD) into Type 1 alveolar epithelial cells (AT1s). In the prese...

    Authors: Elhusseiny Mohamed Mahmud Abdelwahab, Judit Rapp, Diana Feller, Veronika Csongei, Szilard Pal, Domokos Bartis, David R. Thickett and Judit Erzsebet Pongracz

    Citation: Respiratory Research 2019 20:204

    Content type: Research

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  2. Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer death in the world, and has a relatively low survival rate. Long non-coding RNAs (lncRNAs) have been demonstrated to modulate cancer pr...

    Authors: Shengjie Chen, Tianyi Gu, Ziwen Lu, Lipeng Qiu, Guoliang Xiao, Xiaozhong Zhu, Feng Li, Hui Yu, Gang Li and Hanqing Liu

    Citation: Respiratory Research 2019 20:202

    Content type: Research

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  3. Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is progressive and not fully reversible. Cigarette smoking is one of the most commonly and important risk factors for CO...

    Authors: Xiaobo Liang, Xiang He, Yin Li, Junyi Wang, Dehong Wu, Xiefang Yuan, Xiaoyun Wang and Guoping Li

    Citation: Respiratory Research 2019 20:201

    Content type: Research

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  4. Chronic Obstructive Pulmonary Disease (COPD) is a complex disease resulting in respiratory failure and represents the third leading cause of global death. The two classical phenotypes of COPD are chronic bronc...

    Authors: Jack H. Wellmerling, Sheng-Wei Chang, Eunsoo Kim, Wissam H. Osman, Prosper N. Boyaka, Michael T. Borchers and Estelle Cormet-Boyaka

    Citation: Respiratory Research 2019 20:200

    Content type: Letter to the Editor

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  5. Patients with idiopathic pulmonary fibrosis (IPF) have impaired health-related quality of life (HRQL). To measure HRQL, an IPF-specific version of the St. George’s Respiratory Questionnaire (SGRQ-I) was develo...

    Authors: Thomas Skovhus Prior, Nils Hoyer, Saher Burhan Shaker, Jesper Rømhild Davidsen, Janelle Yorke, Ole Hilberg and Elisabeth Bendstrup

    Citation: Respiratory Research 2019 20:199

    Content type: Research

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  6. There is a relationship between Chronic Obstructive Pulmonary Disease (COPD) and the development of lung cancer (LC). The aim of this study is to analyse several blood markers and compare their concentrations ...

    Authors: Cecilia Mouronte-Roibás, Virginia Leiro-Fernández, Alberto Ruano-Raviña, Cristina Ramos-Hernández, Pedro Casado-Rey, Maribel Botana-Rial, Esmeralda García-Rodríguez and Alberto Fernández-Villar

    Citation: Respiratory Research 2019 20:198

    Content type: Research

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  7. Interleukin-33 is released in the airways following acute ozone exposure and has the ability to cause airway hyperresponsiveness, a defining feature of asthma. Ozone causes greater airway hyperresponsiveness i...

    Authors: David I. Kasahara, Jeremy E. Wilkinson, Youngji Cho, Aline P. Cardoso, Curtis Huttenhower and Stephanie A. Shore

    Citation: Respiratory Research 2019 20:197

    Content type: Research

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  8. The pathology of chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and most lung cancers involves the small airway epithelium (SAE), the single continuous layer of cells lining ...

    Authors: Guoqing Wang, Howard H. Lou, Jacqueline Salit, Philip L. Leopold, Sharon Driscoll, Juergen Schymeinsky, Karsten Quast, Sudha Visvanathan, Jay S. Fine, Matthew J. Thomas and Ronald G. Crystal

    Citation: Respiratory Research 2019 20:196

    Content type: Research

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  9. Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils woul...

    Authors: Steven J. Pascoe, Alberto Papi, Dawn Midwinter, Sally Lettis and Neil Barnes

    Citation: Respiratory Research 2019 20:195

    Content type: Research

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  10. The aim of this study was to investigate the effects and mechanisms of ectonucleoside triphosphate phosphohydrolase-7 (ENTPD7) on lung cancer cells.

    Authors: Zhongwei Wen, Rongfang Jiang, Ying Huang, Zhineng Wen, Dong Rui, Xiaoxiao Liao and Zhougui Ling

    Citation: Respiratory Research 2019 20:194

    Content type: Research

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  11. It is unclear whether the responses of refractory and common Mycoplasma pneumoniae (MP) pneumonia to macrolides differ. Hence, this study aimed to identify biomarkers that may be used to distinguish refractory an...

    Authors: Young-Jin Choi, Ju-Hee Jeon and Jae-Won Oh

    Citation: Respiratory Research 2019 20:193

    Content type: Research

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  12. Acute respiratory distress syndrome (ARDS) is characterized by alveolar epithelial disruption. Lipoxins (LXs), as so-called “braking signals” of inflammation, are the first mediators identified to have dual an...

    Authors: Jing-xiang Yang, Ming Li, Xin-ou Chen, Qing-quan Lian, Qian Wang, Fang Gao, Sheng-wei Jin and Sheng-xing Zheng

    Citation: Respiratory Research 2019 20:192

    Content type: Research

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  13. Although COPD affects both men and women, its prevalence is increasing more rapidly in women. Disease outcomes appear different among women with more frequent dyspnea and anxiety or depression but whether this...

    Authors: Maeva Zysman, Pierre-Régis Burgel, Isabelle Court-Fortune, Graziella Brinchault-Rabin, Pascale Nesme-Meyer, Pascale Surpas, Gaetan Deslée, Thierry Perez, Olivier Le Rouzic, Gilles Jebrak, Pascal Chanez, Jean-Louis Paillasseur, Denis Caillaud and Nicolas Roche

    Citation: Respiratory Research 2019 20:191

    Content type: Letter to the Editor

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  14. Patients with chronic obstructive pulmonary disease (COPD) have high oxidative stress associated with the severity of the disease. Nuclear factor erythroid-2 related factor 2 (Nrf2)-directed stress response pl...

    Authors: Venkataramana K. Sidhaye, Janet T. Holbrook, Alyce Burke, Kuladeep R. Sudini, Sanjay Sethi, Gerard J. Criner, Jed W. Fahey, Charles S. Berenson, Michael R. Jacobs, Rajesh Thimmulappa, Robert A. Wise and Shyam Biswal

    Citation: Respiratory Research 2019 20:190

    Content type: Research

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  15. The number of pharmacological agents and guidelines available for COPD has increased markedly but guidelines remain poorly followed. Understanding underlying clinical reasoning is challenging and could be info...

    Authors: Nicolas Roche, Anestis Antoniadis, David Hess, Pei Zhi Li, Eric Kelkel, Sylvie Leroy, Christophe Pison, Pierre-Régis Burgel and Bernard Aguilaniu

    Citation: Respiratory Research 2019 20:189

    Content type: Research

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  16. Endothelial dysfunction is one of the most important early indicators of atherosclerosis in obstructive sleep apnea (OSA) patients. Endothelial cell specific molecules-1 (ESM-1), which is a novel endothelial d...

    Authors: Haili Sun, Fang Fang, Kun Li, Huina Zhang, Ming Zhang, Lichuan Zhang, Juan Li, Yanwen Qin and Yongxiang Wei

    Citation: Respiratory Research 2019 20:188

    Content type: Research

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  17. Acute pulmonary embolism (APE) is one of the leading causes of death in cardiovascular disease. The 30-day mortality can still be 1.7–15% in non-high-risk APE patients. Some non-high-risk patients can progress...

    Authors: Dong Jia, Xue-lian Li, Qin Zhang, Gang Hou, Xiao-ming Zhou and Jian Kang

    Citation: Respiratory Research 2019 20:187

    Content type: Research

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  18. An important goal of chronic obstructive pulmonary disease (COPD) treatment is to reduce the frequency of exacerbations. Some observations suggest a decline in exacerbation rates in clinical trials over time. ...

    Authors: Stefan Andreas, Christian Röver, Judith Heinz, Sebastian Straube, Henrik Watz and Tim Friede

    Citation: Respiratory Research 2019 20:186

    Content type: Research

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  19. We previously reported cryobiopsy (Cryo) with endobronchial ultrasonography-guide sheath (EBUS-GS) for peripheral pulmonary lesions (PPLs) provides significantly larger tissues than transbronchial biopsy (TBB)...

    Authors: Ken Arimura, Mitsuko Kondo, Yoji Nagashima, Masato Kanzaki, Fumi Kobayashi, Kiyoshi Takeyama, Jun Tamaoki and Etsuko Tagaya

    Citation: Respiratory Research 2019 20:185

    Content type: Research

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  20. Influenza attacks the epithelium of the lung, causing cell death and disruption of the epithelial barrier leading to fluid buildup in the lung and impairment of gas exchange. Limited treatment options for seve...

    Authors: K. D. Hebert, N. Mclaughlin, Zhe Zhang, A. Cipriani, J. F. Alcorn and D. A. Pociask

    Citation: Respiratory Research 2019 20:184

    Content type: Research

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  21. Asthma is a heterogeneous lung disease, usually characterised by chronic airway inflammation. Although evidence-based treatments are available in most countries, asthma control remains suboptimal, and asthma-r...

    Authors: Jaya Muneswarao, Mohamed Azmi Hassali, Baharudin Ibrahim, Bandana Saini, Irfhan Ali Hyder Ali and Ashutosh Kumar Verma

    Citation: Respiratory Research 2019 20:183

    Content type: Commentary

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  22. Previous studies have shown that the co-existence of bone marrow failure and pulmonary fibrosis in a single patient or in a family is suggestive of telomere related genes (TRG) germline mutations. This study p...

    Authors: Spyros A. Papiris, Panagiotis Tsirigotis, Caroline Kannengiesser, Lykourgos Kolilekas, Konstantinos Gkirkas, Andriana I. Papaioannou, Patrick Revy, Paschalina Giouleka, Georgia Papadaki, Konstantinos Kagouridis, Vassiliki Pappa, Raphael Borie, Catherine Boileau, Demosthenes Bouros, Bruno Crestani and Effrosyni D. Manali

    Citation: Respiratory Research 2019 20:182

    Content type: Letter to the Editor

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  23. KRAS is a GTPase that activates pathways involved in cell growth, differentiation and survival. In normal cells, KRAS-activity is tightly controlled, but with specific mutations, the KRAS protein is persistent...

    Authors: Fumihiro Ogawa, Matthew S. Walters, Afrah Shafquat, Sarah L. O’Beirne, Robert J. Kaner, Jason G. Mezey, Haijun Zhang, Philip L. Leopold and Ronald G. Crystal

    Citation: Respiratory Research 2019 20:181

    Content type: Research

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  24. CHF6001 is a novel inhaled phosphodiesterase-4 inhibitor. This Phase IIa study assessed the effects of CHF6001 on markers of inflammation in induced sputum and blood in patients with chronic obstructive pulmon...

    Authors: Dave Singh, Kai Michael Beeh, Brendan Colgan, Oliver Kornmann, Brian Leaker, Henrik Watz, Germano Lucci, Silvia Geraci, Aida Emirova, Mirco Govoni and Marie Anna Nandeuil

    Citation: Respiratory Research 2019 20:180

    Content type: Research

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  25. Blood eosinophil counts and history of exacerbations have been proposed as predictors of patients with chronic obstructive pulmonary disease (COPD) who may benefit from triple therapy (inhaled corticosteroid, ...

    Authors: Claus F. Vogelmeier, Konstantinos Kostikas, Juanzhi Fang, Hengfeng Tian, Bethan Jones, Christopher Ll Morgan, Robert Fogel, Florian S. Gutzwiller and Hui Cao

    Citation: Respiratory Research 2019 20:178

    Content type: Research

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  26. Generally, structural destruction of lung parenchyma, such as pulmonary emphysema, is considered to be related to the low diagnostic yields and high complication rates of lung biopsies of peripheral lung lesio...

    Authors: Kyu Min Lee, Geewon Lee, Ahreum Kim, Jeongha Mok, Ji Won Lee, Yeon Joo Jeong, Eun-Jung Jo, Mi Hyun Kim, Kwangha Lee, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee and Jung Seop Eom

    Citation: Respiratory Research 2019 20:177

    Content type: Research

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  27. Effects of systemic corticosteroids on blood gene expression are largely unknown. This study determined gene expression signature associated with short-term oral prednisone therapy in patients with chronic obs...

    Authors: Hiroto Takiguchi, Virginia Chen, Ma’en Obeidat, Zsuzsanna Hollander, J. Mark FitzGerald, Bruce M. McManus, Raymond T. Ng and Don D. Sin

    Citation: Respiratory Research 2019 20:176

    Content type: Research

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  28. The amount of surfactant deposited in the lungs and its overall pulmonary distribution determine the therapeutic outcome of surfactant replacement therapy. Most of the currently available methods to determine ...

    Authors: Riccardo Zecchi, Pietro Franceschi, Laura Tigli, Francesca Ricci, Francesca Boscaro, Barbara Pioselli, Valentina Mileo, Xabier Murgia, Federico Bianco, Fabrizio Salomone, Augusto F. Schmidt, Noah H. Hillman, Matthew W. Kemp and Alan H. Jobe

    Citation: Respiratory Research 2019 20:175

    Content type: Research

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  29. Persistent pulmonary hypertension of the newborn (PPHN) is a severe clinical problem among neonatal intensive care unit (NICU) patients. The genetic pathogenesis of PPHN is unclear. Only a few genetic polymorp...

    Authors: Xu Liu, Mei Mei, Xiang Chen, Yulan Lu, Xinran Dong, Liyuan Hu, Xiaojing Hu, Guoqiang Cheng, Yun Cao, Lin Yang and Wenhao Zhou

    Citation: Respiratory Research 2019 20:174

    Content type: Research

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  30. Despite the availability of treatment guidelines and inhaled medications for asthma and chronic obstructive pulmonary disease (COPD), much remains to be done to lessen the burden of these respiratory diseases ...

    Authors: David A. Leather, Louisa Yates, Henrik Svedsater, Loretta Jacques, Susan Collier, Danielle Powell and Rupert Jones

    Citation: Respiratory Research 2019 20:173

    Content type: Commentary

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  31. Genome wide association (GWA) studies have reproducibly identified signals on chromosome 4q24 associated with lung function and COPD. GSTCD (Glutathione S-transferase C-terminal domain containing) represents a ca...

    Authors: Amanda P. Henry, Kelly Probert, Ceri E. Stewart, Dhruma Thakker, Sangita Bhaker, Sheyda Azimi, Ian P. Hall and Ian Sayers

    Citation: Respiratory Research 2019 20:172

    Content type: Research

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  32. Metabolic adaptation in immune cells is necessary to modulate immune cell function as it is intricately coupled with intracellular metabolism. We aimed to characterize the metabolic state of human peripheral b...

    Authors: Amit R Agarwal, Smita Kadam, Ankita Brahme, Manas Agrawal, Komalkirti Apte, Govinda Narke, Kushal Kekan, Sapna Madas and Sundeep Salvi

    Citation: Respiratory Research 2019 20:171

    Content type: Research

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  33. Chronic obstructive pulmonary disease (COPD) is predominantly associated with neutrophilic inflammation. Active neutrophil elastase (NE) is a serine proteinase, secreted by neutrophils, in response to inflamma...

    Authors: Samantha J. Thulborn, Vijay Mistry, Christopher E. Brightling, Kelly L. Moffitt, David Ribeiro and Mona Bafadhel

    Citation: Respiratory Research 2019 20:170

    Content type: Research

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  34. We assessed the efficacy of the licensed mepolizumab dose (100 mg subcutaneously [SC]) in patients with severe eosinophilic asthma according to body weight/body mass index (BMI).

    Authors: Frank C. Albers, Alberto Papi, Camille Taillé, Daniel J. Bratton, Eric S. Bradford, Steven W. Yancey and Namhee Kwon

    Citation: Respiratory Research 2019 20:169

    Content type: Research

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  35. Pulmonary fibrosis is a progressive disease characterized by structural distortion of the lungs. Transforming growth factor-beta (TGF-beta) is a key cytokine implicated in the pathogenesis of pulmonary fibrosi...

    Authors: Eleanor B. Reed, Shawn Ard, Jennifer La, Chan Young Park, Laura Culligan, Jeffrey J. Fredberg, Larisa V. Smolyaninova, Sergei N. Orlov, Bohao Chen, Robert Guzy, Gökhan M. Mutlu and Nickolai O. Dulin

    Citation: Respiratory Research 2019 20:168

    Content type: Research

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  36. Long-term use of inhaled corticosteroids (ICSs) has been associated with increased risk of bone and ocular comorbidities. We evaluated the effects of the triple fixed-dose combination budesonide/glycopyrrolate...

    Authors: Edward M. Kerwin, Gary T. Ferguson, Mindy Mo, Kiernan DeAngelis and Paul Dorinsky

    Citation: Respiratory Research 2019 20:167

    Content type: Research

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  37. Patients with chronic obstructive pulmonary disease (COPD) have elevated cardiovascular risk, and cardiovascular disease is a major cause of death in COPD. The current literature indicates that changes in card...

    Authors: Yousef S. Aldabayan, Heidi A. Ridsdale, Ahmed M. Alrajeh, Abdulelah M. Aldhahir, Arthur Lemson, Jaber S. Alqahtani, Jeremy S. Brown and John R. Hurst

    Citation: Respiratory Research 2019 20:166

    Content type: Research

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  38. Complement factor C5 can either aggravate or attenuate the T-helper type 2 (TH2) immune response and airway hyperresponsiveness (AHR) in murine models of allergic asthma. The effect of C5 during the effector phas...

    Authors: Jack Yang, Ivan Ramirez Moral, Cornelis van ’t Veer, Alex F. de Vos, Regina de Beer, Joris J. T. H. Roelofs, B. Paul Morgan and Tom van der Poll

    Citation: Respiratory Research 2019 20:165

    Content type: Research

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  39. Approximately 30% of patients with epidermal growth factor receptor (EGFR)-activating mutations have no response to EGFR-tyrosine kinase inhibitors (TKIs) (primary resistance). However, little is known about t...

    Authors: Yang Zhang, Yuanyuan Zeng, Ting Liu, Wenwen Du, Jianjie Zhu, Zeyi Liu and Jian-an Huang

    Citation: Respiratory Research 2019 20:164

    Content type: Research

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  40. Pulmonary fibrosis is a progressive and irreversible disease for which therapeutic options are currently limited. A recent in vivo study showed that tenofovir, a nucleotide analogue reverse transcriptase inhib...

    Authors: Lingxia Li, Jing Zhao, Li Zhou, Jie Chen, Yuanyuan Ma, Yanyan Yu and Jun Cheng

    Citation: Respiratory Research 2019 20:163

    Content type: Research

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  41. Animal models remain invaluable for study of respiratory diseases, however, translation of data generated in genetically homogeneous animals housed in a clean and well-controlled environment does not necessari...

    Authors: Guanghui Liu, Catherine Betts, Danen M. Cunoosamy, Per M. Åberg, Jorrit J. Hornberg, Kinga Balogh Sivars and Taylor S. Cohen

    Citation: Respiratory Research 2019 20:162

    Content type: Review

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  42. Emphysema, characterized by lung destruction, is a key component of Chronic Obstructive Pulmonary Disease (COPD) and is associated with increased morbidity and mortality. Genome-wide association studies (GWAS)...

    Authors: Woori Kim, Michael H. Cho, Phuwanat Sakornsakolpat, David A. Lynch, Harvey O. Coxson, Ruth Tal-Singer, Edwin K. Silverman and Terri H. Beaty

    Citation: Respiratory Research 2019 20:160

    Content type: Research

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  43. The primary lung function endpoint in clinical trials in adolescent and adult patients with asthma is usually forced expiratory volume in one second (FEV1). The objective of our analysis was to assess whether pea...

    Authors: David M. G. Halpin, Eli O. Meltzer, Wendelgard Pisternick-Ruf, Petra Moroni-Zentgraf, Michael Engel, Liliana Zaremba-Pechmann, Thomas Casale and J. Mark FitzGerald

    Citation: Respiratory Research 2019 20:159

    Content type: Research

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  44. Respiratory Distress Syndrome (RDS) is a prematurity-related breathing disorder caused by a quantitative deficiency of pulmonary surfactant. Surfactant replacement therapy is effective for RDS newborns, althou...

    Authors: Sonia Giambelluca, Francesca Ricci, Manuela Simonato, Luca Vedovelli, Umberto Traldi, Alessio Correani, Costanza Casiraghi, Matteo Storti, Arianna Mersanne, Paola Cogo, Fabrizio Salomone and Virgilio P. Carnielli

    Citation: Respiratory Research 2019 20:158

    Content type: Research

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  45. Chronic obstructive pulmonary disease (COPD) is related to endothelial dysfunction and the impaired generation of nitric oxide (NO) from L-arginine by the endothelial NO synthase (eNOS). The relationship betwe...

    Authors: Balázs Csoma, András Bikov, Lajos Nagy, Bence Tóth, Tamás Tábi, Gergő Szűcs, Zsolt István Komlósi, Veronika Müller, György Losonczy and Zsófia Lázár

    Citation: Respiratory Research 2019 20:156

    Content type: Research

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  46. Conflicting data have reported beneficial effects of crystalloids, hyper-oncotic albumin (20%ALB), and iso-oncotic albumin (5%ALB) in critically ill patients. Although hyper-oncotic albumin may minimize lung i...

    Authors: Renata de S. Mendes, Milena V. Oliveira, Gisele A. Padilha, Nazareth N. Rocha, Cintia L. Santos, Ligia A. Maia, Marcos V. de S. Fernandes, Fernanda F. Cruz, Priscilla C. Olsen, Vera L. Capelozzi, Marcelo Gama de Abreu, Paolo Pelosi, Patricia R. M. Rocco and Pedro L. Silva

    Citation: Respiratory Research 2019 20:155

    Content type: Research

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  47. Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study ...

    Authors: Takuto Miyamura, Noriho Sakamoto, Tomoyuki Kakugawa, Daisuke Okuno, Hirokazu Yura, Shota Nakashima, Hiroshi Ishimoto, Takashi Kido, Daisuke Taniguchi, Takuro Miyazaki, Tomoshi Tsuchiya, Shin Tsutsui, Hiroyuki Yamaguchi, Yasushi Obase, Yuji Ishimatsu, Kazuto Ashizawa…

    Citation: Respiratory Research 2019 20:154

    Content type: Research

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  48. Quantitative computed tomographic (QCT) imaging-based metrics enable to quantify smoking induced disease alterations and to identify imaging-based clusters for current smokers. We aimed to derive clinically me...

    Authors: Babak Haghighi, Sanghun Choi, Jiwoong Choi, Eric A. Hoffman, Alejandro P. Comellas, John D. Newell Jr, Chang Hyun Lee, R. Graham Barr, Eugene Bleecker, Christopher B. Cooper, David Couper, Mei Lan Han, Nadia N. Hansel, Richard E. Kanner, Ella A. Kazerooni, Eric A. C. Kleerup…

    Citation: Respiratory Research 2019 20:153

    Content type: Research

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