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  1. Subepithelial fibrosis is one of the most critical structural changes affecting bronchial airway function during asthma. Eosinophils have been shown to contribute to the production of pro-fibrotic cytokines, T...

    Authors: Saleh Al-Muhsen, Severine Letuve, Alejandro Vazquez-Tello, Mary Angeline Pureza, Hamdan Al-Jahdali, Ahmed S Bahammam, Qutayba Hamid and Rabih Halwani
    Citation: Respiratory Research 2013 14:34
    Content type: Research Published on:

  2. Cigarette smoking is associated with increased frequency and duration of viral respiratory infections, but the underlying mechanisms are incompletely defined. We investigated whether smoking reduces expression...

    Authors: Jill C Todt, Christine M Freeman, Jeanette P Brown, Joanne Sonstein, Theresa M Ames, Alexandra L McCubbrey, Fernando J Martinez, Stephen W Chensue, James M Beck and Jeffrey L Curtis
    Citation: Respiratory Research 2013 14:33
    Content type: Research Published on:

  3. Regular exercise is positively associated with health. It has also been suggested to exert anti-inflammatory effects. In healthy subjects, a single exercise session results in immune cell activation, which is ...

    Authors: Pauline Barbera van de Weert-van Leeuwen, Hubertus Gerardus Maria Arets, Cornelis Korstiaan van der Ent and Jeffrey Matthijn Beekman
    Citation: Respiratory Research 2013 14:32
    Content type: Review Published on:

  4. Although renal impairment has been described in COPD, there is opportunity to evaluate further to determine nature and consider optimal management. Increased aortic stiffness, as seen in COPD, leads to reduced...

    Authors: Michelle John, Samia Hussain, Andrew Prayle, Rebecca Simms, John R Cockcroft and Charlotte E Bolton
    Citation: Respiratory Research 2013 14:31
    Content type: Research Published on:

  5. Marked accumulation of alveolar macrophages (AM) conferred by apoptosis resistance has been implicated in pathogenesis of chronic obstructive pulmonary disease (COPD). Apoptosis inhibitor of macrophage (AIM), ...

    Authors: Jun Kojima, Jun Araya, Hiromichi Hara, Saburo Ito, Naoki Takasaka, Kenji Kobayashi, Satoko Fujii, Chikako Tsurushige, Takanori Numata, Takeo Ishikawa, Kenichiro Shimizu, Makoto Kawaishi, Keisuke Saito, Noriki Kamiya, Jun Hirano, Makoto Odaka…
    Citation: Respiratory Research 2013 14:30
    Content type: Research Published on:

  6. Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in the initiation and modulation of immune responses. Human circulating blood DCs are divided into two major subsets: my...

    Authors: Yumeko Hayashi, Yoshiki Ishii, Mitsumi Hata-Suzuki, Ryo Arai, Kazuyuki Chibana, Akihiro Takemasa and Takeshi Fukuda
    Citation: Respiratory Research 2013 14:29
    Content type: Research Published on:

  7. Clinical studies showed the contribution of viral infection to the development of asthma. Although mast cells have multiple roles in the pathogenesis of allergic asthma, their role of in the virus-associated p...

    Authors: Keiko Kan-o, Yuko Matsunaga, Satoru Fukuyama, Atsushi Moriwaki, Hiroko Hirai-Kitajima, Takehiko Yokomizo, Kosuke Aritake, Yoshihiro Urade, Yoichi Nakanishi, Hiromasa Inoue and Koichiro Matsumoto
    Citation: Respiratory Research 2013 14:28
    Content type: Research Published on:

  8. The role and mechanism of action of MIF in bronchopulmonary dysplasia (BPD) are not known. We hypothesized that increased MIF signaling would ameliorate the pulmonary phenotype of BPD in the mouse lung.

    Authors: Huanxing Sun, Rayman Choo-Wing, Juan Fan, Lin Leng, Mansoor A Syed, Alissa A Hare, William L Jorgensen, Richard Bucala and Vineet Bhandari
    Citation: Respiratory Research 2013 14:27
    Content type: Research Published on:

  9. The editors of Respiratory Research would like to thank all of our reviewers who have contributed to the journal in Volume 13 (2012).

    Authors: Jan Lötvall and Reynold A Panettieri Jr
    Citation: Respiratory Research 2013 14:12
    Content type: Reviewer acknowledgement Published on:

  10. Little is known about factors contributing to children’s asthma control status and health-related quality of life (HRQoL). The study objectives were to assess the relationship between asthma control and asthma...

    Authors: Pranav K Gandhi, Kelly M Kenzik, Lindsay A Thompson, Darren A DeWalt, Dennis A Revicki, Elizabeth A Shenkman and I-Chan Huang
    Citation: Respiratory Research 2013 14:26
    Content type: Research Published on:

  11. Vitamin D has effects on the innate and adaptive immune system. In asthmatic children low vitamin D levels are associated with poor asthma control, reduced lung function, increased medication intake, and exace...

    Authors: Stephanie Korn, Marisa Hübner, Matthias Jung, Maria Blettner and Roland Buhl
    Citation: Respiratory Research 2013 14:25
    Content type: Research Published on:

  12. Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are s...

    Authors: Renata Ferrari, Suzana E Tanni, Laura MO Caram, Corina Corrêa, Camila R Corrêa and Irma Godoy
    Citation: Respiratory Research 2013 14:24
    Content type: Research Published on:

  13. Loss of the pulmonary microvasculature in the pathogenesis of emphysema has been put forward as a credible alternative to the classical inflammatory cell driven proteolysis hypothesis. Mechanistic studies in t...

    Authors: Laura S Mackay, Sara Dodd, Iain G Dougall, Wendy Tomlinson, James Lordan, Andrew J Fisher and Paul A Corris
    Citation: Respiratory Research 2013 14:23
    Content type: Research Published on:

  14. Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using nega...

    Authors: Shu-Chuan Ho, Horng-Chyuan Lin, Han-Pin Kuo, Li-Fei Chen, Te-Fang Sheng, Wen-Ching Jao, Chun-Hua Wang and Kang-Yun Lee
    Citation: Respiratory Research 2013 14:22
    Content type: Research Published on:

  15. Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteogl...

    Authors: Anna-Karin Larsson-Callerfelt, Oskar Hallgren, Annika Andersson-Sjöland, Lena Thiman, Johan Björklund, Josefine Kron, Kristian Nihlberg, Leif Bjermer, Claes-Göran Löfdahl and Gunilla Westergren-Thorsson
    Citation: Respiratory Research 2013 14:21
    Content type: Research Published on:

  16. Accumulating evidence reveals that intrauterine growth retardation (IUGR) can cause varying degrees of pulmonary arterial hypertension (PAH) later in life. Moreover, epigenetics plays an important role in the ...

    Authors: Xue-Feng Xu, Ying Lv, Wei-Zhong Gu, Li-Li Tang, Jia-Kai Wei, Li-Yan Zhang and Li-Zhong Du
    Citation: Respiratory Research 2013 14:20
    Content type: Research Published on:

  17. Individuals with deficiencies of pulmonary surfactant protein C (SP-C) develop interstitial lung disease (ILD) that is exacerbated by viral infections including respiratory syncytial virus (RSV). SP-C gene tar...

    Authors: Stephan W Glasser, Albert P Senft, Melissa D Maxfield, Teah L Ruetschilling, John E Baatz, Kristen Page and Thomas R Korfhagen
    Citation: Respiratory Research 2013 14:19
    Content type: Research Published on:

  18. The diagnosis of sarcoidosis is still a significant challenge in China because of the need to exclude other diseases including granulomatous infections and malignancies that may be clinically and radiographica...

    Authors: Yuan Zhang, Xianqiu Chen, Yang Hu, Shanshan Du, Li Shen, Yifan He, Yuxuan Zhang, Xia Zhang, Huiping Li and Rex C Yung
    Citation: Respiratory Research 2013 14:18
    Content type: Research Published on:

  19. Severe asthma is a heterogeneous disease and the relationship between airway inflammation and airway remodelling is poorly understood. We sought to define sputum mediator profiles in severe asthmatics categori...

    Authors: Dhananjay Desai, Sumit Gupta, Salman Siddiqui, Amisha Singapuri, William Monteiro, James Entwisle, Sudha Visvanathan, Harsukh Parmar, Radhika Kajekar and Christopher E Brightling
    Citation: Respiratory Research 2013 14:17
    Content type: Research Published on:

  20. No study has been carried out on the time trend in the prevalence of chronic bronchitis (CB) in recent years, despite its clinical and epidemiological relevance. We evaluated the trend in CB prevalence during ...

    Authors: Simone Accordini, Angelo Guido Corsico, Isa Cerveri, Leonardo Antonicelli, Francesco Attena, Roberto Bono, Lucio Casali, Marcello Ferrari, Alessandro Fois, Pierpaolo Marchetti, Pietro Pirina, Roberta Tassinari, Giuseppe Verlato and Roberto de Marco
    Citation: Respiratory Research 2013 14:16
    Content type: Research Published on:

  21. Rhinovirus (RV) is a major cause of chronic obstructive pulmonary disease (COPD) exacerbations, and primarily infects bronchial epithelial cells. Immune responses from BECs to RV infection are critical in limi...

    Authors: Katherine J Baines, Alan C-Y Hsu, Melinda Tooze, Lakshitha P Gunawardhana, Peter G Gibson and Peter AB Wark
    Citation: Respiratory Research 2013 14:15
    Content type: Research Published on:

  22. We previously reported that asthmatic children with GSTM1 null genotype may be more susceptible to the acute effect of ozone on the small airways and might benefit from antioxidant supplementation. This study aim...

    Authors: Hortensia Moreno-Macías, Douglas W Dockery, Joel Schwartz, Diane R Gold, Nan M Laird, Juan J Sienra-Monge, Blanca E Del Río-Navarro, Matiana Ramírez-Aguilar, Albino Barraza-Villarreal, Huiling Li, Stephanie J London and Isabelle Romieu
    Citation: Respiratory Research 2013 14:14
    Content type: Research Published on:

  23. Toll-like receptors (TLRs) on T cells can modulate their responses, however, the extent and significance of TLR expression by lung T cells, NK cells, or NKT cells in chronic obstructive pulmonary disease (COPD...

    Authors: Christine M Freeman, Fernando J Martinez, MeiLan K Han, George R Washko, Jr, Alexandra L McCubbrey, Stephen W Chensue, Douglas A Arenberg, Catherine A Meldrum, Lisa McCloskey and Jeffrey L Curtis
    Citation: Respiratory Research 2013 14:13
    Content type: Research Published on:

  24. Increased airway wall thickness (AWT) and parenchymal lung destruction bothcontribute to airflow limitation. Advances in computed tomography (CT)post-processing imaging allow to quantify these features. The ai...

    Authors: Akkelies E Dijkstra, Dirkje S Postma, Nick ten Hacken, Judith M Vonk, Matthijs Oudkerk, Peter MA van Ooijen, Pieter Zanen, Firdaus A Mohamed Hoesein, Bram van Ginneken, Michael Schmidt and Harry JM Groen
    Citation: Respiratory Research 2013 14:11
    Content type: Research Published on:

  25. The pathogenesis of COPD is complex and remains poorly understood. The European Respiratory Society Study on Chronic Obstructive Pulmonary Disease (EUROSCOP) investigated long-term effects of budesonide; 18% o...

    Authors: Fatemeh Fattahi, Nick H T ten Hacken, Claes-Göran Löfdahl, Machteld N Hylkema, Wim Timens, Dirkje S Postma and Judith M Vonk
    Citation: Respiratory Research 2013 14:10
    Content type: Research Published on:

  26. Mesenchymal stem cells (MSC) are in clinical trials for widespread indications including musculoskeletal, neurological, cardiac and haematological disorders. Furthermore, MSC can ameliorate pulmonary fibrosis ...

    Authors: Khondoker M Akram, Sohel Samad, Monica A Spiteri and Nicholas R Forsyth
    Citation: Respiratory Research 2013 14:9
    Content type: Research Published on:

  27. Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neu...

    Authors: Hikari Koga, Nobuaki Miyahara, Yasuko Fuchimoto, Genyo Ikeda, Koichi Waseda, Katsuichiro Ono, Yasushi Tanimoto, Mikio Kataoka, Erwin W Gelfand, Mitsune Tanimoto and Arihiko Kanehiro
    Citation: Respiratory Research 2013 14:8
    Content type: Research Published on:

  28. Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products...

    Authors: Isham Huizar, Anagha Malur, Janki Patel, Matthew McPeek, Larry Dobbs, Christopher Wingard, Barbara P Barna and Mary Jane Thomassen
    Citation: Respiratory Research 2013 14:7
    Content type: Research Published on:

  29. Reduced gas transfer in patients with pulmonary arterial hypertension (PAH) is traditionally attributed to remodeling and progressive loss of pulmonary arterial vasculature that results in decreased capillary ...

    Authors: Samar Farha, Daniel Laskowski, Deepa George, Margaret M Park, WH Wilson Tang, Raed A Dweik and Serpil C Erzurum
    Citation: Respiratory Research 2013 14:6
    Content type: Research Published on:

  30. Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it’s role in the inflammatory respons...

    Authors: Etsuko Kurimoto, Nobuaki Miyahara, Arihiko Kanehiro, Koichi Waseda, Akihiko Taniguchi, Genyo Ikeda, Hikari Koga, Hisakazu Nishimori, Yasushi Tanimoto, Mikio Kataoka, Yoichiro Iwakura, Erwin W Gelfand and Mitsune Tanimoto
    Citation: Respiratory Research 2013 14:5
    Content type: Research Published on:

  31. Human leukocyte antigen (HLA)-G is a nonclassical class I antigen with immunomodulatory roles including up-regulation of suppressor T regulatory lymphocytes. HLA-G was recently identified as an asthma suscepti...

    Authors: Steven R White, Dagan A Loisel, Randi Stern, Bharathi Laxman, Timothy Floreth and Bertha A Marroquin
    Citation: Respiratory Research 2013 14:4
    Content type: Research Published on:

  32. Aim of this prospective study was to compare clinical and genetic findings in children with idiopathic or heritable pulmonary arterial hypertension (I/HPAH) with children affected with congenital heart defects...

    Authors: Nicole Pfarr, Christine Fischer, Nicola Ehlken, Tabea Becker-Grünig, Vanesa López-González, Matthias Gorenflo, Alfred Hager, Katrin Hinderhofer, Oliver Miera, Christian Nagel, Dietmar Schranz and Ekkehard Grünig
    Citation: Respiratory Research 2013 14:3
    Content type: Research Published on:

  33. Stromal interaction molecule 1 (STIM1) is a newly discovered Ca2+ sensor on the endoplasmic reticulum which is an indispensable part in the activation of store-operated Ca2+ channels (SOC). Recent studies demonst...

    Authors: Xianhua Hou, Jian Chen, Yongjun Luo, Fuyu Liu, Gang Xu and Yuqi Gao
    Citation: Respiratory Research 2013 14:2
    Content type: Research Published on:

  34. Both chronic hypoxia and allergic inflammation induce vascular remodeling in the lung, but only chronic hypoxia appears to cause PH. We investigate the nature of the vascular remodeling and the expression and ...

    Authors: Daniel J Angelini, Qingning Su, Kazuyo Yamaji-Kegan, Chunling Fan, John T Skinner, Andre Poloczek, Hazim El-Haddad, Chris Cheadle and Roger A Johns
    Citation: Respiratory Research 2013 14:1
    Content type: Research Published on:

  35. Quantifying the improvements in lower limb or quadriceps muscle mass following resistance training (RT), is an important outcome measure in COPD. Ultrasound is a portable, radiation free imaging technique that...

    Authors: Manoj K Menon, Linzy Houchen, Samantha Harrison, Sally J Singh, Michael D Morgan and Michael C Steiner
    Citation: Respiratory Research 2012 13:119
    Content type: Research Published on:

  36. Guaifenesin is a component of medicines used to improve symptoms associated with upper respiratory tract infections. Patient-reported outcome instruments are valuable for evaluating symptom improvements; howev...

    Authors: Helmut Albrecht, Margaret Vernon and Gail Solomon
    Citation: Respiratory Research 2012 13:118
    Content type: Research Published on:

  37. There is an increasing interest in the potential of exhaled biomarkers, such as volatile organic compounds (VOCs), to improve accurate diagnoses and management decisions in pulmonary diseases. The objective of...

    Authors: Kim DG van de Kant, Linda JTM van der Sande, Quirijn Jöbsis, Onno CP van Schayck and Edward Dompeling
    Citation: Respiratory Research 2012 13:117
    Content type: Review Published on:

  38. Chronic Obstructive Pulmonary Disease (COPD) is characterised by complex inflammatory, neuronal and fibrotic changes. Brain-derived Neurotrophic Factor (BDNF) is a key regulator of neuronal plasticity, whereas...

    Authors: Paul Stoll, Urs Wuertemberger, Kai Bratke, Christiana Zingler, J Christian Virchow and Marek Lommatzsch
    Citation: Respiratory Research 2012 13:116
    Content type: Research Published on:

  39. Reasons for the excess risk for cardiovascular disease among people with chronic obstructive pulmonary disease remain unclear. Our objective was to examine the cardiovascular risk profile for adults with obstr...

    Authors: Earl S Ford, Anne G Wheaton, David M Mannino, Letitia Presley-Cantrell, Chaoyang Li and Janet B Croft
    Citation: Respiratory Research 2012 13:115
    Content type: Research Published on:

  40. The effectiveness of strategies for treatment of the altered static lung volume and against the development of bronchial hyperreactivity (BHR) following a left ventricular dysfunction (LVD) induced by myocardi...

    Authors: Ferenc Petak, Gergely Albu, Eniko Lele, Maurice Beghetti and Walid Habre
    Citation: Respiratory Research 2012 13:114
    Content type: Research Published on:

  41. Haemophilus influenzae is the most common colonizing bacteria of the bronchial tree in chronic obstructive pulmonary disease (COPD), and positive cultures for this potentially pathogenic microorganism (PPM) has b...

    Authors: Laura Millares, Alicia Marin, Judith Garcia-Aymerich, Jaume Sauleda, José Belda and Eduard Monsó
    Citation: Respiratory Research 2012 13:113
    Content type: Research Published on:

  42. The study aimed at prospectively evaluating the evolution of asthma control in Italy, to evaluate the reasons for lack of asthma control, perceived quality of life (QoL) and association with level of asthma co...

    Authors: Claudio Terzano, Giovanni Cremonesi, Giuseppe Girbino, Eleonora Ingrassia, Serafino Marsico, Gabriele Nicolini and Luigi Allegra
    Citation: Respiratory Research 2012 13:112
    Content type: Commentary Published on:

  43. Prognostic assessment is important for the management of patients with acute pulmonary embolism (APE). Pulmonary Embolism Severity Index (PESI) and simple PESI (sPESI) are new emerged prognostic assessment too...

    Authors: Xiao-Yu Zhou, Su-Qin Ben, Hong-Lin Chen and Song-Shi Ni
    Citation: Respiratory Research 2012 13:111
    Content type: Research Published on:

  44. Docosahexaenoic acid (DHA) and DHA-derived lipid mediators have recently been shown to possess anti-inflammatory and pro-resolving properties. In fact, DHA can down-regulate lipolysaccharide (LPS)-induced acti...

    Authors: Zenglin Liao, Jiajia Dong, Wei Wu, Ting Yang, Tao Wang, Lingli Guo, Lei Chen, Dan Xu and Fuqiang Wen
    Citation: Respiratory Research 2012 13:110
    Content type: Research Published on:

  45. Relationships between improvements in lung function and other clinical outcomes in chronic obstructive pulmonary disease (COPD) are not documented extensively. We examined whether changes in trough forced expi...

    Authors: Paul W Jones, James F Donohue, Jerry Nedelman, Steve Pascoe, Gregory Pinault and Cheryl Lassen
    Citation: Respiratory Research 2012 12:161
    Content type: Research Published on:

  46. Only 10-15% of smokers develop chronic obstructive pulmonary disease (COPD) which indicates genetic susceptibility to the disease. Recent studies suggested an association between COPD and polymorphisms in CHRNA c...

    Authors: Jing Zhang, Hanssa Summah, Ying-gang Zhu and Jie-Ming Qu
    Citation: Respiratory Research 2012 12:158
    Content type: Research Published on:

  48. Increased pulmonary arterial vascular smooth muscle (PAVSM) cell proliferation is a key pathophysiological component of pulmonary vascular remodeling in pulmonary arterial hypertension (PH). The long-acting β2-ad...

    Authors: Elena A Goncharova, Irene S Khavin, Dmitry A Goncharov and Vera P Krymskaya
    Citation: Respiratory Research 2012 13:109
    Content type: Research Published on:

  49. Statins are lipid-lowering agents that also exhibit pleiotropic effects in decreasing oxidative stress and inflammation. There have been several published studies reporting the use of statins in the treatment ...

    Authors: Cheng Yuan, Lin Zhou, Jiyun Cheng, Jingying Zhang, Yue Teng, Mao Huang, Ian M Adcock, Peter J Barnes and Xin Yao
    Citation: Respiratory Research 2012 13:108
    Content type: Review Published on:
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Respiratory Research

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