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Page 57 of 57

  1. Deficient microbial stimulation of the immune system, caused by hygiene, may underly the atopy and allergic asthma epidemic we are currently experiencing. Consistent with this 'hygiene hypothesis', research on...

    Authors: Paolo Maria Matricardi and Sergio Bonini

    Citation: Respiratory Research 2000 1:2

    Content type: Commentary

    Published on:

  2. Many pulmonary diseases preferentially affect the large airways or the alveoli. Although the mechanisms are often particular to each disease process, site-specific differences in leukocyte trafficking and the ...

    Authors: Claire M Doerschuk

    Citation: Respiratory Research 2000 1:4

    Content type: Review

    Published on:

  3. Regeneration and restoration of the airway epithelium after mechanical, viral or bacterial injury have a determinant role in the evolution of numerous respiratory diseases such as chronic bronchitis, asthma an...

    Authors: Edith Puchelle and Bruno Peault

    Citation: Respiratory Research 2000 1:1

    Content type: Commentary

    Published on:

  4. The identification of the cystic fibrosis (CF) gene opened the way for gene therapy. In the ten years since then, proof of principle in vitro and then in animal models in vivo has been followed by numerous clinic...

    Authors: Myra Stern, M Geddes Duncan and WFW Alton Eric

    Citation: Respiratory Research 2000 1:3

    Content type: Commentary

    Published on:

  5. The acute respiratory distress syndrome (ARDS) is an inflammatory disease of the lungs characterized clinically by bilateral pulmonary infiltrates, decreased pulmonary compliance and hypoxemia. Although suppor...

    Authors: Arthur S Slutsky and V Marco Ranieri

    Citation: Respiratory Research 2000 1:2

    Content type: Commentary

    Published on:

  6. Surfactant protein-D (SP-D) participates in the innate response to inhaled microorganisms and organic antigens, and contributes to immune and inflammatory regulation within the lung. SP-D is synthesized and se...

    Authors: Erika C Crouch

    Citation: Respiratory Research 2000 1:6

    Content type: Review

    Published on:

  7. Secretory leukocyte proteinase inhibitor and elafin are two low-molecular-mass elastase inhibitors that are mainly synthesized locally at mucosal sites. It is thought that their physicochemical properties allo...

    Authors: Jean-Michel Sallenave

    Citation: Respiratory Research 2000 1:5

    Content type: Review

    Published on:

  8. Inflammatory diseases of the respiratory tract are commonly associated with elevated production of nitric oxide (NO•) and increased indices of NO• -dependent oxidative stress. Although NO• is known to have ant...

    Authors: Albert van der Vliet, Jason P Eiserich and Carroll E Cross

    Citation: Respiratory Research 2000 1:1

    Content type: Commentary

    Published on:

  9. Airway hyper-reactivity is a characteristic feature of many inflammatory lung diseases and is defined as an exaggerated degree of airway narrowing. Chemokines and their receptors are involved in several pathol...

    Authors: Kate Blease, Nicholas W Lukacs, Cory M Hogaboam and Steven L Kunkel

    Citation: Respiratory Research 2000 1:13

    Content type: Review

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  10. The cellular and molecular mechanisms that are involved in airway hyper-responsiveness are unclear. Current studies suggest that tumor necrosis factor (TNF)-α, a cytokine that is produced in considerable quant...

    Authors: Yassine Amrani, Hang Chen and Reynold A Panettieri Jr

    Citation: Respiratory Research 2000 1:12

    Content type: Review

    Published on:

  11. PM10 (the mass of particles present in the air having a 50% cutoff for particles with an aerodynamic diameter of 10 μm) is the standard measure of particulate air pollution used worldwide. Epidemiological studies...

    Authors: Kenneth Donaldson, M Ian Gilmour and William MacNee

    Citation: Respiratory Research 2000 1:5

    Content type: Commentary

    Published on:

  12. The medical research community is experiencing a marked increase in the amount of information available on genomic sequences and genes expressed by humans and other organisms. This information offers great opp...

    Authors: Edward Gabrielson

    Citation: Respiratory Research 2000 1:10

    Content type: Review

    Published on:

  13. The limitations of currently available treatment for severe respiratory infection are demonstrated by the relatively fixed mortality associated with these infections despite advances in nutrition, vaccines, an...

    Authors: K Kolls Jay and Steve Nelson

    Citation: Respiratory Research 2000 1:4

    Content type: Commentary

    Published on:

  14. Phosphoinositide 3-kinases (PI-3Ks) are enzymes that generate lipid second messenger molecules, resulting in the activation of multiple intracellular signalling cascades. These events regulate a broad array of...

    Authors: Alison M Condliffe, Karen A Cadwallader, Trevor R Walker, Robert C Rintoul, Andrew S Cowburn and Edwin R Chilvers

    Citation: Respiratory Research 2000 1:8

    Content type: Review

    Published on:

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