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  1. SARS-CoV-2 infected patients show heterogeneous clinical presentations ranging from mild symptoms to severe respiratory failure and death. Consequently, various markers reflect this wide spectrum of disease pr...

    Authors: Julia Beimdiek, Sabina Janciauskiene, Sabine Wrenger, Sonja Volland, Adriana Rozy, Jan Fuge, Beata Olejnicka, Isabell Pink, Thomas Illig, Alexander Popov, Joanna Chorostowska, Falk F. R. Buettner and Tobias Welte
    Citation: Respiratory Research 2022 23:343
  2. At the time of the SARS-CoV-2 emergence, asthma patients were initially considered vulnerable because respiratory viruses, especially influenza, are associated with asthma exacerbations, increased risk of hosp...

    Authors: Axelle Dupont, Camille Couffignal, Camila Arias, Kankoe Salah, Mathilde Phillips-Houlbraq, Mathilde Le Brun and Camille Taillé
    Citation: Respiratory Research 2022 23:342
  3. Anxiety and depression are comorbidities of severe asthma. However, clinical characteristics associated with coexisting severe asthma and anxiety/depression are poorly understood. The study objective is to det...

    Authors: Michelle A. Stubbs, Vanessa L. Clark, Peter G. Gibson, Janelle Yorke and Vanessa M. McDonald
    Citation: Respiratory Research 2022 23:341
  4. Premature infants, subjected to supplemental oxygen and mechanical ventilation, may develop bronchopulmonary dysplasia, a chronic lung disease characterized by alveolar dysplasia and impaired vascularization. ...

    Authors: Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. Huntington, Monique E. De Paepe and Phyllis A. Dennery
    Citation: Respiratory Research 2022 23:340
  5. Alpha-1 antitrypsin deficiency (AATD) is characterized by reduced serum levels of the AAT protein and predisposes to liver and lung disease. The characterization at structural level of novel pathogenic SERPINA...

    Authors: Angel Gonzalez, Irene Belmonte, Alexa Nuñez, Georgina Farago, Miriam Barrecheguren, Mònica Pons, Gerard Orriols, Pablo Gabriel-Medina, Francisco Rodríguez-Frías, Marc Miravitlles and Cristina Esquinas
    Citation: Respiratory Research 2022 23:339
  6. PM2.5 exposure is associated with lung adenocarcinoma (LUAD), but the mechanism is unclear. The lack of understanding impedes our effort on prevention. This study examined a possible mechanism of lung cancer caus...

    Authors: Tengteng Zhu, Yangyang Li, Tienan Feng, Yuqing Yang, Kai Zhang, Jing Gao, Xiaowei Quan, Ying Qian, Herbert Yu and Biyun Qian
    Citation: Respiratory Research 2022 23:338
  7. Airway instillation of bleomycin (BLM) in mice is a widely used, yet challenging, model for acute lung injury (ALI) with high variability in treatment scheme and animal outcomes among investigators. Whether th...

    Authors: Young me Yoon, Cara L. Hrusch, Na Fei, Gabriel M. Barrón, Kathleen A. M. Mills, Maile K. Hollinger, Tania E. Velez, Vanessa A. Leone, Eugene B. Chang and Anne I. Sperling
    Citation: Respiratory Research 2022 23:337
  8. The global initiative for chronic obstructive lung disease (GOLD) 2020 emphasizes that there is only a weak correlation between FEV1, symptoms and impairment of the health status of patients with chronic obstruct...

    Authors: Cathelijne M. van Zelst, Lucas M. A. Goossens, Jan A. Witte, Gert-Jan Braunstahl, Rudi W. Hendriks, Maureen P. M. H. Rutten-van Molken and Johannes C. C. M. in’t Veen
    Citation: Respiratory Research 2022 23:336
  9. Studies in adult severe treatment-resistant asthma (STRA) have demonstrated heterogeneous pathophysiology. Studies in the pediatric age group are still scarce, and few include bronchial tissue analysis.

    Authors: Miriam Cardoso Neves Eller, Karina Pierantozzi Vergani, Beatriz Mangueira Saraiva-Romanholo, Natália de Souza Xavier Costa, Jôse Mára de Brito, Leila Antonangelo, Caroline Silvério Faria, Joaquim Carlos Rodrigues and Thais Mauad
    Citation: Respiratory Research 2022 23:335
  10. Antifibrotic therapy can slow disease progression (DP) in patients with idiopathic pulmonary fibrosis (IPF). However, the prognostic biomarkers for DP in patients with IPF receiving antifibrotic therapy have n...

    Authors: Myeong Geun Choi, Sun Mi Choi, Jae Ha Lee, Joong-Yub Kim and Jin Woo Song
    Citation: Respiratory Research 2022 23:334
  11. The nasal cannula is considered a trusted and effective means of administering low-flow oxygen and is widely used for neonates and infants requiring oxygen therapy, despite an understanding that oxygen concent...

    Authors: Mozhgan Sabz, Scott Tavernini, Kineshta Pillay, Cole Christianson, Michelle Noga, Warren H. Finlay, Hossein Rouhani and Andrew R. Martin
    Citation: Respiratory Research 2022 23:333

    The Correction to this article has been published in Respiratory Research 2023 24:94

  12. Diffuse interstitial lung diseases (ILD) constitute a heterogeneous group of conditions with complex etiological diagnoses requiring a multidisciplinary approach. Much is still unknown about them, particularly...

    Authors: Ségolene Carlier, Mouhamad Nasser, Emmanuel Fort, Céline Lamouroux, Salim Si-Mohamed, Lara Chalabreysse, Jean-Michel Maury, Rémi Diesler, Vincent Cottin and Barbara Charbotel
    Citation: Respiratory Research 2022 23:332
  13. Pulmonary hypertension (PH) is a frequent complication in COPD and it is associated with decreased exercise capacity and poor prognosis. We hypothesized that even in COPD patients without significant PH at res...

    Authors: Teresa Sassmann, Philipp Douschan, Vasile Foris, Natascha Tröster, Katarina Zeder, Luka Brcic, Adrienn Tornyos, Gerhard Bachmaier, Michael Fuchsjäger, Horst Olschewski and Gabor Kovacs
    Citation: Respiratory Research 2022 23:331
  14. Use of long-term tobramycin inhalation solution (TIS) has been shown beneficial in cystic fibrosis (CF) and earlier findings also suggest a benefit in non-CF bronchiectasis. We investigated the efficacy and sa...

    Authors: Lotte C. Terpstra, Josje Altenburg, Inez Bronsveld, Martijn D. de Kruif, Yvonne Berk, Dominic Snijders, Wouter Rozemeijer, Harry G. M. Heijerman and Wim G. Boersma
    Citation: Respiratory Research 2022 23:330
  15. High-flow nasal oxygen therapy (HFNC) may be an attractive first-line ventilatory support in COVID-19 patients. However, HNFC use for the management of COVID-19 patients and risk factors for HFNC failure remai...

    Authors: Zakaria Ait Hamou, Nathan Levy, Julien Charpentier, Jean-Paul Mira, Matthieu Jamme and Mathieu Jozwiak
    Citation: Respiratory Research 2022 23:329
  16. Bronchiectasis is a highly heterogeneous chronic airway disease with marked geographic and ethnic variations. Most influential cohort studies to date have been performed in Europe and USA, which serve as the e...

    Authors: Yong-Hua Gao, Hai-Wen Lu, Bei Mao, Wei-Jie Guan, Yuan-Lin Song, Yuan-Yuan Li, Dao-Xin Wang, Bin Wang, Hong-Yan Gu, Wen Li, Hong Luo, Ling-Wei Wang, Fan Li, Feng-Xia Guo, Min Zhang, Zhi-Jun Jie…
    Citation: Respiratory Research 2022 23:328
  17. Acute respiratory distress syndrome (ARDS) is one of the most severe complications of SARS-CoV-2 infection. Non-Invasive Respiratory Support (NRS) as Continuous Positive Airway Pressure (CPAP) and/or Non-Invas...

    Authors: Riccardo Nevola, Antonio Russo, Samuel Scuotto, Simona Imbriani, Concetta Aprea, Marianna Abitabile, Domenico Beccia, Chiara Brin, Caterina Carusone, Francesca Cinone, Giovanna Cirigliano, Sara Colantuoni, Domenico Cozzolino, Giovanna Cuomo, Micol Del Core, Klodian Gjeloshi…
    Citation: Respiratory Research 2022 23:327
  18. Bacterial pneumonia is a major risk factor for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Pseudomonas aeruginosa (PA), an opportunistic pathogen with an increasing resistance acquired...

    Authors: Nagaraja Nagre, Gregory Nicholson, Xiaofei Cong, Janette Lockett, Andrew C. Pearson, Vincent Chan, Woong-Ki Kim, K. Yaragudri Vinod and John D. Catravas
    Citation: Respiratory Research 2022 23:326
  19. Without aggressive treatment, pulmonary arterial hypertension (PAH) has a 5-year mortality of approximately 40%. A patient’s response to vasodilators at diagnosis impacts the therapeutic options and prognosis....

    Authors: Tilo Winkler, Puja Kohli, Vanessa J. Kelly, Ekaterina G. Kehl, Alison S. Witkin, Josanna M. Rodriguez-Lopez, Kathryn A. Hibbert, Mamary T. Kone, David M. Systrom, Aaron B. Waxman, Jose G. Venegas, Richard N. Channick and R. Scott Harris
    Citation: Respiratory Research 2022 23:325
  20. The physiological response and the potentially beneficial effects of positive end-expiratory pressure (PEEP) for lung protection and optimization of ventilation during spontaneous breathing in patients with ac...

    Authors: Hannes Widing, Elena Chiodaroli, Francesco Liggieri, Paola Sara Mariotti, Katarina Hallén and Gaetano Perchiazzi
    Citation: Respiratory Research 2022 23:324
  21. Influenza viruses cause seasonal epidemics worldwide with a significant morbimortality burden. Clinical spectrum of Influenza is wide, being respiratory failure (RF) one of its most severe complications. This ...

    Authors: Blanca Ayuso, Antonio Lalueza, Estibaliz Arrieta, Eva María Romay, Álvaro Marchán-López, María José García-País, Dolores Folgueira, María José Gude, Cecilia Cueto, Antonio Serrano and Carlos Lumbreras
    Citation: Respiratory Research 2022 23:323
  22. Our previous study showed that circular RNA-gamma-secretase-activating protein (circGSAP) was down-regulated in pulmonary microvascular endothelial cells (PMECs) in response to hypoxia, and regulated the cell ...

    Authors: Yuanyuan Sun, Rong Jiang, Xiaoyi Hu, Sugang Gong, Lan Wang, Wenhui Wu, Jinling Li, Xinyang Kang, Shijin Xia, Jinming Liu, Qinhua Zhao and Ping Yuan
    Citation: Respiratory Research 2022 23:322
  23. The role of the sputum microbiome in chronic obstructive pulmonary disease (COPD) progression remains elusive. As the advent of the new culture-independent microbial sequencing technique makes it possible to d...

    Authors: Wei Li, Bingbing Wang, Min Tan, Xiaolian Song, Shuanshuan Xie and Changhui Wang
    Citation: Respiratory Research 2022 23:321
  24. COVID-19 related acute respiratory distress syndrome (ARDS) has specific characteristics compared to ARDS in other populations. Proning is recommended by analogy with other forms of ARDS, but few data are avai...

    Authors: Andrea Boffi, Maximilien Ravenel, Ermes Lupieri, Antoine Schneider, Lucas Liaudet, Michel Gonzalez, Jean-Daniel Chiche and Lise Piquilloud
    Citation: Respiratory Research 2022 23:320
  25. Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease that is characterised by persistent respiratory symptoms and airflow limitation. The present study reported the burden of COP...

    Authors: Hamidreza Feizi, Mahasti Alizadeh, Seyed Aria Nejadghaderi, Maryam Noori, Mark J. M. Sullman, Javad Ahmadian Heris, Ali-Asghar Kolahi, Gary S. Collins and Saeid Safiri
    Citation: Respiratory Research 2022 23:319
  26. In the last decade, research on acute respiratory distress syndrome (ARDS) has made considerable progress. However, ARDS remains a leading cause of mortality in the intensive care unit. ARDS presents distinct ...

    Authors: Denise Battaglini, Lou’i Al-Husinat, Ana Gabriela Normando, Adriana Paes Leme, Kleber Franchini, Marcelo Morales, Paolo Pelosi and Patricia RM Rocco
    Citation: Respiratory Research 2022 23:318
  27. Emerging experimental and epidemiological evidence highlights a crucial cross-talk between the intestinal flora and the lungs, termed the “gut-lung axis”. However, the function of the gut microbiota in bronchi...

    Authors: Wen-Wen Wang, Bei Mao, Yang Liu, Shu-Yi Gu, Hai-Wen Lu, Jiu-Wu Bai, Shuo Liang, Jia-Wei Yang, Jian-Xiong Li, Xiao Su, Hai-Yang Hu, Chen Wang and Jin-Fu Xu
    Citation: Respiratory Research 2022 23:317
  28. Eosinophilic asthma is a common subtype of severe asthma with high morbidity and mortality. The cytokine IL-5 has been shown to be a key driver of the development and progression of disease. Although approved ...

    Authors: Linlin Ma, Min Zhu, Guanghui Li, Junwei Gai, Yanfei Li, Huaiyu Gu, Peng Qiao, Xiaofei Li, Weiwei Ji, Rui Zhao, Yue Wu and Yakun Wan
    Citation: Respiratory Research 2022 23:316
  29. Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been com...

    Authors: Kensuke Nakagawara, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Shuhei Azekawa, Shiro Otake, Takahiro Fukushima, Atsuho Morita, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Takanori Asakura, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii…
    Citation: Respiratory Research 2022 23:315
  30. Pregnant women with pulmonary hypertension (PH) have higher mortality rates and poor foetal/neonatal outcomes. Tools to assess these risk factors are not well established.

    Authors: Yuqin Chen, Dansha Zhou, Mingmei Xiong, Xin Xi, Wenni Zhang, Ruifeng Zhang, Lishi Chen, Qian Jiang, Ning Lai, Xiang Li, Jieer Luo, Xuanyi Li, Weici Feng, Chuhui Gao, Jiyuan Chen, Xin Fu…
    Citation: Respiratory Research 2022 23:314

    The Correction to this article has been published in Respiratory Research 2023 24:4

  31. Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we ...

    Authors: Javier Milara, Inés Roger, Paula Montero, Enrique Artigues, Juan Escrivá and Julio Cortijo
    Citation: Respiratory Research 2022 23:313
  32. The COMPERA 2.0 4-stratum (4-S) risk score has been demonstrated superior over the 3-stratum (3-S) one in patients with pulmonary arterial hypertension and medically managed patients with chronic thromboemboli...

    Authors: Yi Zhang, Xin Li, Qi Jin, Qin Luo, Qing Zhao, Tao Yang, Qixian Zeng, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Zhihui Zhao and Zhihong Liu
    Citation: Respiratory Research 2022 23:312
  33. Chronic obstructive pulmonary disease (COPD) is a disease of accelerated aging and is associated with comorbid conditions including osteoporosis and sarcopenia. These extrapulmonary conditions are highly preva...

    Authors: Ava C. Wilson, Jessica M. Bon, Stephanie Mason, Alejandro A. Diaz, Sharon M. Lutz, Raul San Jose Estepar, Gregory L. Kinney, John E. Hokanson, Stephen I. Rennard, Richard Casaburi, Surya P. Bhatt, Marguerite R. Irvin, Craig P. Hersh, Mark T. Dransfield, George R. Washko, Elizabeth A. Regan…
    Citation: Respiratory Research 2022 23:311
  34. Airway macrophages (AM), crucial for the immune response in chronic obstructive pulmonary disease (COPD), are exposed to environmental particulate matter (PM), which they retain in their cytoplasm as black car...

    Authors: Vickram Tejwani, Han Woo, Chen Liu, Anna K. Tillery, Amanda J. Gassett, Richard E. Kanner, Eric A. Hoffman, Fernando J. Martinez, Prescott G. Woodruff, R. Graham Barr, Ashraf Fawzy, Kirsten Koehler, Jeffrey L. Curtis, Christine M. Freeman, Christopher B. Cooper, Alejandro P. Comellas…
    Citation: Respiratory Research 2022 23:310
  35. Preserved Ratio Impaired Spirometry (PRISm) is defined as FEV1/FVC ≥ 70% and FEV1 < 80%pred by pulmonary function test (PFT). It has highly prevalence and is associated with increased respiratory symptoms, sys...

    Authors: Jinjuan Lu, Haiyan Ge, Lin Qi, Shaojie Zhang, Yuling Yang, Xuemei Huang and Ming Li
    Citation: Respiratory Research 2022 23:309

    The Correction to this article has been published in Respiratory Research 2023 24:31

  36. Idiopathic pulmonary fibrosis, the archetype of pulmonary fibrosis (PF), is a chronic lung disease of a poor prognosis, characterized by progressively worsening of lung function. Although histology is still th...

    Authors: Elena Vincenzi, Alice Fantazzini, Curzio Basso, Annalisa Barla, Francesca Odone, Ludovica Leo, Laura Mecozzi, Martina Mambrini, Erica Ferrini, Nicola Sverzellati and Franco Fabio Stellari
    Citation: Respiratory Research 2022 23:308
  37. Patients with interstitial lung disease (ILD) require regular physician visits and referral to specialist ILD clinics. Difficulties or delays in accessing care can limit opportunities to monitor disease trajec...

    Authors: Toby M. Maher, Courtney Schiffman, Michael Kreuter, Catharina C. Moor, Steven D. Nathan, Judit Axmann, Paula Belloni, Monica Bengus, Frank Gilberg, Klaus-Uwe Kirchgaessler and Marlies S. Wijsenbeek
    Citation: Respiratory Research 2022 23:307
  38. The club cell secretory protein (CC16) has anti-inflammatory and antioxidant effects and is a potential early biomarker of lung damage. The CC16 single nucleotide polymorphism (SNP) rs3741240 risk allele (A) has ...

    Authors: KC Gribben, AB Wyss, JA Poole, PA Farazi, C Wichman, M Richards-Barber, LE Beane Freeman, PK Henneberger, DM Umbach, SJ London and TD LeVan
    Citation: Respiratory Research 2022 23:305

    The Correction to this article has been published in Respiratory Research 2022 23:350

  39. Authors: Hideyasu Yamada, Isao Matsumoto, Naoyuki Makita, Yoshifumi Arita, Nobuya Hayashi, Kurena Mitsuoka, Naoki Tashiro and Nobuyuki Hizawa
    Citation: Respiratory Research 2022 23:304

    The original article was published in Respiratory Research 2022 23:255

  40. Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19. However, the prognost...

    Authors: Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai and Jorge D. Erusalimsky
    Citation: Respiratory Research 2022 23:303
  41. Currently, programmed death ligand-1 (PD-L1) expression has been widely applied in clinical trials and real-world clinical practice as a major biomarker for the efficacy of immune-checkpoint inhibitors. The pu...

    Authors: Fangqiu Fu, Chaoqiang Deng, Wenrui Sun, Qiang Zheng, Yan Jin, Yuan Li, Yang Zhang and Haiquan Chen
    Citation: Respiratory Research 2022 23:302
  42. Acute respiratory distress syndrome (ARDS) is an acute and critical disease among children and adults, and previous studies have shown that the administration of corticosteroids remains controversial. Therefor...

    Authors: Xinyan Chang, Shaojun Li, Yueqiang Fu, Hongxing Dang and Chengjun Liu
    Citation: Respiratory Research 2022 23:301
  43. Vaccines against SARS-CoV-2 protect from critical or severe pathogenesis also against new variants of concern (VOCs) such as BA.4 and BA.5, but immediate interventions to avoid viral transmission and subsequen...

    Authors: Viktoria Zaderer, Stefanie Dichtl, Rosa Bellmann Weiler, Cornelia Lass Flörl, Wilfried Posch and Doris Wilflingseder
    Citation: Respiratory Research 2022 23:300

    The Correction to this article has been published in Respiratory Research 2023 24:27

  44. The effect of ambient temperature on respiratory mortality has been consistently observed throughout the world under different climate change scenarios. Countries experiencing greater inter–annual variability ...

    Authors: Shafkat Jahan, John Paul Cauchi, Charles Galdies, Kathleen England and Darren Wraith
    Citation: Respiratory Research 2022 23:299
  45. Preserved ratio impaired spirometry (PRISm) refers to decreased forced expiratory volume in 1 s (FEV1) in the setting of preserved ratio. Little is known about the role of PRISm and its complex relation with smal...

    Authors: Ningning Zhao, Fan Wu, Jieqi Peng, Youlan Zheng, Heshen Tian, Huajing Yang, Zhishan Deng, Zihui Wang, Haiqing Li, Xiang Wen, Shan Xiao, Peiyu Huang, Cuiqiong Dai, Lifei Lu, Kunning Zhou, Shengtang Chen…
    Citation: Respiratory Research 2022 23:298
  46. Routine follow-up of patients hospitalised with COVID-19 is recommended, however due to the ongoing high number of infections this is not without significant health resource and economic burden. In a previous ...

    Authors: Tim JM Wallis, Benjamin Welham, Alex Kong, Tommaso Morelli, Adnan Azim, Jose Horno, Miranda Wilkinson, Hannah Burke, Anna Freeman, Thomas MA Wilkinson, Mark G Jones and Benjamin G Marshall
    Citation: Respiratory Research 2022 23:297
  47. Anticoagulant treatment is recommended for at least three months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related acute pulmonary embolism (PE), but the persistent pulmonary clot burd...

    Authors: Thomas M. Berghaus, Stefanie Bader, Christian Faul, Sabine Haberl, Florian Schwarz, Alessandro Liebich, Alexander Dierks, Malte Kircher, Constantin Lapa and Christian H. Pfob
    Citation: Respiratory Research 2022 23:296
  48. Pleuroparenchymal fibroelastosis (PPFE) is a rare fibrosing lung disease with a predilection for the upper lobe and its progression causes hypoventilation, resulting in hypercapnia. Even though the association...

    Authors: Yuki Yabuuchi, Takefumi Saito, Hitomi Hirano, Mizu Nonaka, Naoki Arai, Kentaro Hyodo, Jun Kanazawa, Yukiko Miura, Shingo Usui, Katsumi Tamura, Tomotaka Kasamatsu, Shuji Oh-ishi, Kenji Hayashihara, Masashi Matsuyama and Nobuyuki Hizawa
    Citation: Respiratory Research 2022 23:295
  49. Acute exacerbation (AE) is a major cause of death in patients with idiopathic pulmonary fibrosis (IPF). AE-IPF patients require optimal palliative care; however, the real-world clinical situations are poorly u...

    Authors: Norimichi Akiyama, Tomoyuki Fujisawa, Tatsuya Morita, Takafumi Koyauchi, Yoshinobu Matsuda, Masanori Mori, Mitsunori Miyashita, Ryo Tachikawa, Keisuke Tomii, Hiromi Tomioka, Satoshi Hagimoto, Yasuhiro Kondoh, Yoshikazu Inoue and Takafumi Suda
    Citation: Respiratory Research 2022 23:294

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